Beta-Tocotrienol | CAS:490-23-3 | Manufacturer ChemFaces

Beta-Tocotrienol

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Description:

Beta-Tocotrienol to serve as a new anticancer agent for treating human lung and brain cancers. It inhibits the growth of both A549 (GI50=1.38±0.334μM) and U87MG (GI50=2.53±0.604μM) cells at rather low concentrations.

Targets:

Caspase

In vitro:

Biomed Pharmacother. 2014 Oct;68(8):1105-15.

Antiproliferation and induction of caspase-8-dependent mitochondria-mediated apoptosis by β-tocotrienol in human lung and brain cancer cell lines.[Pubmed: 25456851]

The pure vitamin isomer, Beta-Tocotrienol has the least abundance among the other vitamin E isomers that are present in numerous plants. Hence, it is very scarcely studied for its bioactivity.
METHODS AND RESULTS:
In this study, the antiproliferative effects and primary apoptotic mechanisms of Beta-Tocotrienol on human lung adenocarcinoma A549 and glioblastoma U87MG cells were investigated. It was evidenced that Beta-Tocotrienol had inhibited the growth of both A549 (GI50=1.38±0.334μM) and U87MG (GI50=2.53±0.604μM) cells at rather low concentrations. Cancer cells incubated with Beta-Tocotrienol were also found to exhibit hallmarks of apoptotic morphologies including membrane blebbing, chromatin condensation and formation of apoptotic bodies. The apoptotic properties of Beta-Tocotrienol in both A549 and U87MG cells were the results of its capability to induce significant (P<0.05) double-strand DNA breaks (DSBs) without involving single-strand DNA breaks (SSBs). Beta-Tocotrienol is said to induce activation of caspase-8 in both A549 and U87MG cells guided by no activation when caspase-8 inhibitor, z-IETD-fmk was added. Besides, disruption on the mitochondrial membrane permeability of the cells in a concentration- and time-dependent manner had occurred.
CONCLUSIONS:
The induction of apoptosis by Beta-Tocotrienol in A549 and U87MG cells was confirmed to involve both the death-receptor mediated and mitochondria-dependent apoptotic pathways. These findings could potentiate the palm oil derived Beta-Tocotrienol to serve as a new anticancer agent for treating human lung and brain cancers.

Beta-Tocotrienol Description

Source:	The stem barks of Garcinia virgata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Beta-Tocotrienol
Price:
CAS No.:	490-23-3
Catalog No.:	CFN92822
Molecular Formula:	C₂₈H₄₂O₂
Molecular Weight:	410.6 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The stem barks of Garcinia virgata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-proliferation Compound Library Pro-apoptotic Compound Library Phenols Compound Library Caspase Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4355 mL	12.1773 mL	24.3546 mL	48.7092 mL	60.8865 mL
5 mM	0.4871 mL	2.4355 mL	4.8709 mL	9.7418 mL	12.1773 mL
10 mM	0.2435 mL	1.2177 mL	2.4355 mL	4.8709 mL	6.0887 mL
50 mM	0.0487 mL	0.2435 mL	0.4871 mL	0.9742 mL	1.2177 mL
100 mM	0.0244 mL	0.1218 mL	0.2435 mL	0.4871 mL	0.6089 mL

CFN91685	(+)-gamma-Tocopherol	54-28-4	416.7	C₂₈H₄₈O₂
CFN92817	Gamma-Tocotrienol	14101-61-2	410.6	C₂₈H₄₂O₂
CFN92821	Alpha-Tocotrienol	1721-51-3	424.7	C₂₉H₄₄O₂
CFN90041	DL-alpha-Tocopherol	59-02-9	430.7	C₂₉H₅₀O₂
CFN98999	alpha-Tocopherol acetate	58-95-7	472.8	C₃₁H₅₂O₃
CFN97674	Dehydro-Delta-tocopherol	802909-72-4	400.65	C₂₇H₄₄O₂
CFN91145	(+)-Delta-Tocopherol	119-13-1	402.7	C₂₇H₄₆O₂
CFN98991	Confluentin	585534-03-8	326.5	C₂₂H₃₀O₂
CFN97302	Daurichromenic acid	82003-90-5	370.5	C₂₃H₃₀O₄
CFN92822	Beta-Tocotrienol	490-23-3	410.6	C₂₈H₄₂O₂