Bisdehydroneotuberostemonine | CAS:160333-27-7

Bisdehydroneotuberostemonine

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Description:

Bisdehydroneotuberostemonine shows significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at 100 uM.

Targets:

In vitro:

Records of Natural Products, 2016, 10(1):109-112.

Stemona alkaloids isolated from Stemona tuberosa roots and their inhibitory activity on lipopolysaccharide-induced nitric oxide production[Reference: WebLink]

METHODS AND RESULTS:
A methanol extract of the roots of Stemona tuberosa (Stemonaceae) significantly inhibited lipopolysaccharide-induced nitric oxide production in murine BV2 microglial cells. Eight alkaloids tuberostemonine K (1), neotuberostemonine (2), oxotuberostemonine (3), Bisdehydroneotuberostemonine (4), epibisdehydrotuberostemonine J (5), bisdehydrotuberostemonine (6), tuberostemoninol (7), and neostenine (8) were isolated from the methanolic extract using bioactivity-guided fractionation.
CONCLUSIONS:
Among them, compounds 4, 5 and 6 showed significant inhibitory effect on lipopolysaccharide-induced nitric oxide production in BV2 microglia at 100 μM.

Bisdehydroneotuberostemonine Description

Source:	The roots of Stemona collinsae.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Bisdehydroneotuberostemonine
Price:
CAS No.:	160333-27-7
Catalog No.:	CFN96768
Molecular Formula:	C₂₂H₂₉NO₄
Molecular Weight:	371.47 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The roots of Stemona collinsae.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Alkaloids Compound Library NO Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.692 mL	13.46 mL	26.9201 mL	53.8401 mL	67.3002 mL
5 mM	0.5384 mL	2.692 mL	5.384 mL	10.768 mL	13.46 mL
10 mM	0.2692 mL	1.346 mL	2.692 mL	5.384 mL	6.73 mL
50 mM	0.0538 mL	0.2692 mL	0.5384 mL	1.0768 mL	1.346 mL
100 mM	0.0269 mL	0.1346 mL	0.2692 mL	0.5384 mL	0.673 mL

CFN98725	Neostenine	477953-07-4	277.4	C₁₇H₂₇NO₂
CFN97497	Sessilifoline A	929637-35-4	389.5	C₂₂H₃₁NO₅
CFN97534	Neotuberostemonone	954379-68-1	405.5	C₂₂H₃₁NO₆
CFN98138	Tuberostemonine	6879-01-2	375.51	C₂₂H₃₃NO₄
CFN99475	Neotuberostemonine	143120-46-1	375.5	C₂₂H₃₃NO₄
CFN96768	Bisdehydroneotuberostemonine	160333-27-7	371.47	C₂₂H₂₉NO₄
CFN80139	Protostemonine	27495-40-5	417.21	C₂₃H₃₁NO₆