Canthin-6-one N-oxide | CAS:60755-87-5

Canthin-6-one N-oxide

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Description:

Canthin-6-one N-oxide has broad spectrum antifungal, leishmanicidal and trypanocidal activities.

Targets:

Antifection

In vivo:

J Ethnopharmacol. 2007 Jan 19;109(2):258-63.

Effects of canthin-6-one alkaloids from Zanthoxylum chiloperone on Trypanosoma cruzi-infected mice.[Pubmed: 16949231]

Canthin-6-one (1), isolated from Zanthoxylum chiloperone (Rutaceae), possesses a broad sprectum of antifungal and leishmanicidal activities.
METHODS AND RESULTS:
In this study, we have examined the antiparasitic effects of canthin-6-one (1), 5-methoxycanthin-6-one (2), Canthin-6-one N-oxide (3), as well as that of the total alkaloids of Zanthoxylum chiloperone stem bark, in Balb/c mice infected either acutely or chronically with Trypanosoma cruzi. The compounds were administered orally or subcutaneously at 5mg/kg/day for 2 weeks, whereas the alkaloidal extract was given at 50mg/kg/day for 2 weeks. The antiparasitic activity was compared with that of benznidazole given at 50mg/kg/day for 2 weeks. In the case of acute infection, parasiteamia was significantly reduced following oral treatment with canthin-6-one (1). Moreover, the total alkaloids of Zanthoxylum chiloperone stem bark led to high levels of parasitological clearance. Seventy days post-infection, the serological response in the acute model was significantly different between oral canthin-6-one (1) and benznidazole-treated mice. Chronic model of the disease showed that both canthin-6-one (1) and the alkaloidal extract at the above dosage induced 80-100% animal survival compared to untreated controls.
CONCLUSIONS:
These results indicate that canthin-6-one (1) exhibits trypanocidal activity in vivo in the mouse model of acute or chronic infection. This is the first demonstration of anti-Trypanosoma cruzi activity for a member of this chemical group (canthinones). Considering the very low toxicity of canthin-6-one (1), our results suggest that long-term oral treatment with this natural product could prove advantageous compared to the current chemotherapy of Chagas disease.

Canthin-6-one N-oxide Description

Source:	The roots of Eurycoma harmandiana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Canthin-6-one N-oxide
Price:
CAS No.:	60755-87-5
Catalog No.:	CFN92010
Molecular Formula:	C₁₄H₈N₂O₂
Molecular Weight:	236.2 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Yellow powder
Source:	The roots of Eurycoma harmandiana
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antifungal Compound Library Toxicity Compound Library Antiparasitic Compound Library Alkaloids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.2337 mL	21.1685 mL	42.337 mL	84.674 mL	105.8425 mL
5 mM	0.8467 mL	4.2337 mL	8.4674 mL	16.9348 mL	21.1685 mL
10 mM	0.4234 mL	2.1169 mL	4.2337 mL	8.4674 mL	10.5843 mL
50 mM	0.0847 mL	0.4234 mL	0.8467 mL	1.6935 mL	2.1169 mL
100 mM	0.0423 mL	0.2117 mL	0.4234 mL	0.8467 mL	1.0584 mL

CFN98730	Canthin-6-one	479-43-6	220.2	C₁₄H₈N₂O
CFN92010	Canthin-6-one N-oxide	60755-87-5	236.2	C₁₄H₈N₂O₂
CFN97287	1-Hydroxycanthin-6-one	80787-59-3	236.2	C₁₄H₈N₂O₂
CFN92126	9-Hydroxycanthin-6-one	138544-91-9	236.2	C₁₄H₈N₂O₂
CFN94012	10-Hydroxycanthin-6-one	86293-41-6	236.23	C₁₄H₈N₂O₂
CFN92011	9-Methoxycanthin-6-one	74991-91-6	250.3	C₁₅H₁₀N₂O₂
CFN92012	9-Methoxycanthin-6-one-N-oxide	137739-74-3	266.3	C₁₅H₁₀N₂O₃
CFN92124	1-Hydroxy-9-medroxycanthin-6-one	622408-85-9	266.3	C₁₅H₁₀N₂O₃
CFN92125	11-Hydroxycanthin-6-one	75969-83-4	236.2	C₁₄H₈N₂O₂
CFN92127	9,10-Dimethoxycanthin-6-one	155861-51-1	280.3	C₁₆H₁₂N₂O₃