| In vitro: |
| J Nat Prod. 2002 Jan;65(1):89-91. | | Antiinflammatory constituents of Celastrus orbiculatus inhibit the NF-kappaB activation and NO production.[Pubmed: 11809076] |
METHODS AND RESULTS:
Two new sesquiterpene esters, 1beta,8beta-diacetoxyl-6alpha,9alpha-difuroyloxydihydro-beta-agarofuran (1) and 1beta-acetoxyl-2beta,6alpha,9alpha-trifuroyloxydihydro-beta-agarofuran (2), together with four known sesquiterpene esters (3-6), celastrol (7), and Celaphanol A (8) were isolated from the roots of Celastrus orbiculatus in a search for inhibitors of NF-kappaB activation and nitric oxide production.
CONCLUSIONS:
Compound 7 was the most active, while compounds 1, 2, 4, and 8 showed moderate inhibition in both NF-kappaB activation and nitric oxide production. | | J Nat Prod. 2013 Apr 26;76(4):745-9. | | (M)- and (P)-bicelaphanol A, dimeric trinorditerpenes with promising neuroprotective activity from Celastrus orbiculatus.[Pubmed: 23421714] |
METHODS AND RESULTS:
(M)-BiCelaphanol A (1) and (P)-biCelaphanol A (2), two unprecedented dimeric trinorditerpenes existing as atropisomers, together with their monomer Celaphanol A (3), were isolated from the root bark of Celastrus orbiculatus. The structures and absolute configurations of 1 and 2 were determined by spectroscopic and single-crystal X-ray diffraction analyses.
CONCLUSIONS:
Compound 1 exhibited a significant in vitro neuroprotective effect against a hydrogen peroxide-induced cell viability decrease in PC12 cells at 1 μM, while compounds 2 and 3 showed such effects at 10 μM. |
|
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