Cirsiliol | CAS:34334-69-5 | Manufacturer ChemFaces

Cirsiliol

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Size /Price /Stock	10 mM * 1 mL in DMSO / $185.3 / In-stock
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Description:

Cirsiliol shows antioxidant, and anti-obesity effects, it can inhibit TG accumulation in 3T3-L1 preadipocytes. Cirsiliol and rhamnetin can act as promising radiosensitizers that enhance the radiotherapeutic efficacy by inhibiting radiation-induced Notch-1 signaling associated with radioresistance possibly via miR-34a-mediated pathways.

Targets:

NO | NF-kB

In vitro:

J Nat Med. 2014 Apr;68(2):414-20.

Inhibitory effect of chemical constituents from Artemisia scoparia Waldst. et Kit. on triglyceride accumulation in 3T3-L1 cells and nitric oxide production in RAW 264.7 cells.[Pubmed: 24142543 ]

METHODS AND RESULTS:
We investigated the anti-obesity effect of the aerial part of Artemisia scoparia Waldst. et Kit. (Compositae). An 80 % aqueous EtOH extract of the aerial part inhibited triglyceride (TG) accumulation and the nitric oxide (NO) production activity. A new chromane derivative was isolated from the aerial part of A. scoparia Waldst. et Kit. along with 18 known compounds. The structure of the new chromane, scopariachromane (1), was elucidated by spectroscopic analyses. The inhibitory effects of the compounds on TG accumulation activity were examined. Among these, Cirsiliol (11) inhibited TG accumulation in 3T3-L1 preadipocytes. Jaceosidin (12) inhibited NO production in a murine macrophage-like cell line (RAW 264.7).
CONCLUSIONS:
These results indicate that the 80 % aqueous EtOH extract and compounds isolated from the aerial part of A. scoparia Waldst. et Kit. may improve obesity-related insulin resistance.

J Biol Chem. 2013 Sep 20;288(38):27343-57.

Rhamnetin and cirsiliol induce radiosensitization and inhibition of epithelial-mesenchymal transition (EMT) by miR-34a-mediated suppression of Notch-1 expression in non-small cell lung cancer cell lines.[Pubmed: 23902763 ]

METHODS AND RESULTS:
Treatment with rhamnetin or Cirsiliol reduced the proliferation of NSCLC cells through the suppression of radiation-induced Notch-1 expression. Indeed, rhamnetin and Cirsiliol increased the expression of tumor-suppressive microRNA, miR-34a, in a p53-dependent manner, leading to inhibition of Notch-1 expression. Consequently, reduced Notch-1 expression promoted apoptosis through significant down-regulation of the nuclear factor-κB pathway, resulting in a radiosensitizing effect on NSCLC cells. Irradiation-induced epithelial-mesenchymal transition was also notably attenuated in the presence of rhamnetin and Cirsiliol. Moreover, an in vivo xenograft mouse model confirmed the radiosensitizing and epithelial-mesenchymal transition inhibition effects of rhamnetin and Cirsiliol we observed in vitro. In these mice, tumor volume was significantly reduced by combinational treatment with irradiation and rhamnetin or Cirsiliol compared with irradiation alone.
CONCLUSIONS:
Taken together, our findings provided evidence that rhamnetin and Cirsiliol can act as promising radiosensitizers that enhance the radiotherapeutic efficacy by inhibiting radiation-induced Notch-1 signaling associated with radioresistance possibly via miR-34a-mediated pathways.

Cirsiliol Description

Source:	The aerial parts of Phyla nodiflora.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

ScientificWorldJournal. 2014;2014:528653.

HPLC-fingerprints and antioxidant constituents of Phyla nodiflora.[Pubmed: 25140335]

Phyla nodiflora is a creeping perennial herb, widely distributed in the most tropical and subtropical regions. It has been used as a folk medicine, herbal beverage, or folk cosmetic. For these usages, the development of a chemical quality control method of this plant is necessary.
METHODS AND RESULTS:
In the present study, ten compounds, namely, 3,7,4',5'-tetrahydroxy-3'-methoxyflavone (1), nodifloretin (2), 4'-hydroxywogonin (3), onopordin (4), Cirsiliol (5), 5,7,8,4'-tetrahydroxy-3'-methoxyflavone (6), eupafolin (7), hispidulin (8), larycitrin (9), and β-sitosterol were isolated from the methanolic extract of the aerial part of P. nodiflora (PNM) and their structures were identified by 1D-NMR comparing their spectra with the literature. The antioxidant activities of these compounds were evaluated by free radical scavenging activity and tyrosinase inhibitory effect in cell-free systems. Compounds 4, 5, and 7 showed strong antioxidant activity. To control the quality of P. nodiflora, a simple and reliable method of high-performance liquid chromatography combined with ultraviolet detector (HPLC-UV) was established for both the fingerprint analysis and the quantitative determination of two selected active compounds, onopordin (4) and eupafolin (7). Statistical analysis of the obtained data demonstrated that our method achieved the desired linearity, precision, and accuracy.
CONCLUSIONS:
The results indicated that the developed method can be used as a quality evaluation method for PNM.

Product Name	Cirsiliol
Price:	$268 / 5mg
CAS No.:	34334-69-5
Catalog No.:	CFN96508
Molecular Formula:	C₁₇H₁₄O₇
Molecular Weight:	330.29 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The aerial parts of Phyla nodiflora.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antioxidants Compound Library Anti-obesity Compound Library Radiosensitizers Compound Library Flavonoids Compound Library NO Inhibitor Library NF-kB Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.0276 mL	15.1382 mL	30.2764 mL	60.5528 mL	75.6911 mL
5 mM	0.6055 mL	3.0276 mL	6.0553 mL	12.1106 mL	15.1382 mL
10 mM	0.3028 mL	1.5138 mL	3.0276 mL	6.0553 mL	7.5691 mL
50 mM	0.0606 mL	0.3028 mL	0.6055 mL	1.2111 mL	1.5138 mL
100 mM	0.0303 mL	0.1514 mL	0.3028 mL	0.6055 mL	0.7569 mL

CFN97418	Eupatorin	855-96-9	344.3	C₁₈H₁₆O₇
CFN70313	Eupatorin-5-methylether	21764-09-0	358.4	C₁₉H₁₈O₇
CFN98785	Chrysoeriol	491-71-4	300.3	C₁₆H₁₂O₆
CFN91826	4'-Methylchrysoeriol	4712-12-3	314.3	C₁₇H₁₄O₆
CFN98290	Velutin	25739-41-7	314.3	C₁₇H₁₄O₆
CFN95398	4'-Hydroxy-5,7,3'-trimethoxyflavone	1239-68-5	328.3	C₁₈H₁₆O₆
CFN90386	Jaceosidin	18085-97-7	330.29	C₁₇H₁₄O₇
CFN90418	Cirsilineol	41365-32-6	344.32	C₁₈H₁₆O₇
CFN70278	Gossypetin 3,3',8-trimethylether	14965-08-3	360.3	C₁₈H₁₆O₈
CFN92436	Isothymonin	99615-01-7	360.3	C₁₈H₁₆O₈