Cleroindicin F | CAS:189264-47-9 | Manufacturer ChemFaces

Cleroindicin F

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $227.2 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Cleroindicin F Description

Source:	The herbs of Clerodendrum indicum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Org Chem. 2009 Jun 5;74(11):4104-9.

Enantioselective total synthesis of all of the known chiral cleroindicins (C-F): clarification among optical rotations and assignments.[Pubmed: 19476394]

METHODS AND RESULTS:
Enantioselective syntheses of all of the named chiral members of the Cleroindicin Family (C-F) are reported. This effort demonstrates the synthetic utility of a 2,4-dihydroxybenzaldehyde as a starting material for natural product synthesis through the use sequential o-quinone methide chemistry and diastereoselective dearomatization. Natural Cleroindicin F was shown to be nearly racemic, and an optically pure synthetic sample of Cleroindicin F was found to racemize under slightly basic conditions.
CONCLUSIONS:
All other natural chiral cleroindicins are shown to be partially racemic.

J Org Chem. 2012 Nov 16;77(22):10294-303.

Tandem sequence of phenol oxidation and intramolecular addition as a method in building heterocycles.[Pubmed: 23110614]

METHODS AND RESULTS:
A tandem phenol oxidation-Michael addition furnishing oxo- and -aza-heterocycles has been developed. Dirhodium caprolactamate [Rh(2)(cap)(4)] catalyzed oxidation by T-HYDRO of phenols with alcohols, ketones, amides, carboxylic acids, and N-Boc protected amines tethered to their 4-position afforded 4-(tert-butylperoxy)cyclohexa-2,5-dienones that undergo Brønsted acid catalyzed intramolecular Michael addition in one-pot to produce oxo- and -aza-heterocycles in moderate to good yields. The scope of the developed methodology includes dipeptides Boc-Tyr-Gly-OEt and Boc-Tyr-Phe-Me and provides a pathway for understanding the possible transformations arising from oxidative stress of tyrosine residues.
CONCLUSIONS:
A novel method of selective cleavage of O-O bond in hindered internal peroxide using TiCl(4) has been discovered in efforts directed to the construction of Cleroindicin F, whose synthesis was completed in 50% yield over just 3 steps from tyrosol using the developed methodology.

Product Name	Cleroindicin F
Price:	$463 / 5mg
CAS No.:	189264-47-9
Catalog No.:	CFN99874
Molecular Formula:	C₈H₁₀O₃
Molecular Weight:	154.2 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	Oil
Source:	The herbs of Clerodendrum indicum
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Cytotoxic Compound Library Miscellaneous Compound Library Antifection Inhibitor Library

Description:	Cleroindicin F shows cytotoxic activity against some human cancer cells. Cleroindicin F and apigenin in the ethyl acetate extract provide scientific support to the traditional use of the leaves of C. splendens for the treatment of infections, wounds and other inflammatory conditions.
Targets:	Antifection

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.4851 mL	32.4254 mL	64.8508 mL	129.7017 mL	162.1271 mL
5 mM	1.297 mL	6.4851 mL	12.9702 mL	25.9403 mL	32.4254 mL
10 mM	0.6485 mL	3.2425 mL	6.4851 mL	12.9702 mL	16.2127 mL
50 mM	0.1297 mL	0.6485 mL	1.297 mL	2.594 mL	3.2425 mL
100 mM	0.0649 mL	0.3243 mL	0.6485 mL	1.297 mL	1.6213 mL

CFN97508	Rengyol	93675-85-5	160.2	C₈H₁₆O₃
CFN99080	Cleroindicin B	107389-91-3	158.2	C₈H₁₄O₃
CFN89293	Cornoside	40661-45-8	316.30	C₁₄H₂₀O₈
CFN99696	Cleroindicin E	165197-71-7	158.2	C₈H₁₄O₃
CFN99872	Cleroindicin C	189264-44-6	156.2	C₈H₁₂O₃
CFN99873	Cleroindicin D	189264-45-7	172.2	C₈H₁₂O₄
CFN99874	Cleroindicin F	189264-47-9	154.2	C₈H₁₀O₃
CFN98933	1-Oxo-4-hydroxy-2-en-4-ethylcyclohexa-5,8-olide	55604-88-1	168.2	C₈H₈O₄
CFN99781	Griffonilide	61371-55-9	168.04	C₈H₈O₄