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Clopidogrel Related Compound A
Clopidogrel Related Compound A
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Clopidogrel Related Compound A
Price:
CAS No.: 144457-28-3
Catalog No.: CFN90546
Molecular Formula: C15H14ClNO2S
Molecular Weight: 307.8 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: From Clopidogrel
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Clopidogrel Related Compound A is a impurity from Clopidogrel.
Clopidogrel Related Compound A Description
Source: From Clopidogrel
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 3.2489 mL 16.2443 mL 32.4886 mL 64.9773 mL 81.2216 mL
5 mM 0.6498 mL 3.2489 mL 6.4977 mL 12.9955 mL 16.2443 mL
10 mM 0.3249 mL 1.6244 mL 3.2489 mL 6.4977 mL 8.1222 mL
50 mM 0.065 mL 0.3249 mL 0.6498 mL 1.2995 mL 1.6244 mL
100 mM 0.0325 mL 0.1624 mL 0.3249 mL 0.6498 mL 0.8122 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Der Pharma Chemica;2010,2(4):244.
Non chiral High Performance Liquid Chromatography method for monitoring unknown impurities generated during stability of Clopidogrel tablets[Reference: WebLink]
The purpose of this study was to develop a High performance liquid chromatography (HPLC) method for separating the unknown impurities generated during the accelerated stability storage of Clopidogrel Bisulphate Tablets. Also, we used the newly developed method to identify the factors that contribute to the formation of these unknown impurities in the tablet formulation.
METHODS AND RESULTS:
Study was carried out by incubation of mixture of excipients and Clopidogrel API in 5:1 ratio at 80°C for 3days. The new HPLC method was developed by using Kromasil 100 C18 column and using gradient method with mobile phase of 0.1% Triflouroacetic acid in water in pump A and 0.1% Trifluoroacetic acid in Acetonitrile in pump B was suitable for separating the unknown impurities from the Clopidogrel Related Compound A.The method discussed in United States Pharmacopoeia (USP) is not suitable to separate these impurities. From the excipients compatibility data we hypothesized that these unknown impurities were generated due to the excipient Polyethylene Glycol that is present in the tablet both as a tablet lubricant as well as a part of the film coating system. Further these unknown impurities were characterized as Dihydro pyridinone Derivative, Decarbmethoxylated Clopidogrel.
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