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Coronalolide
Coronalolide
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Coronalolide
Price:
CAS No.: 268214-51-3
Catalog No.: CFN98317
Molecular Formula: C30H42O5
Molecular Weight: 482.7 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The herbs of Gardenia sootepensis hutchins.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Coronalolide shows significant cytotoxic activities in P-388 cell line, it also displays significant anti-HIV activities in the HIV-1RT assay. Coronalolide and coronalolide methyl ester show broad cytotoxic activity against a panel of human cancer cell lines.
Targets: HIV
In vitro:
Int J Microbiol. 2014;2014:410935.
Antibacterial Activities and In Vitro Anti-Inflammatory (Membrane Stability) Properties of Methanolic Extracts of Gardenia coronaria Leaves.[Pubmed: 24695677]

METHODS AND RESULTS:
This work is carried out with Gardenia coronaria leaves that belong to the family Rubiaceae, which is a small-to-medium-sized but tall, deciduous tree, 7.6-9 m high on an average. Leaves are used for the treatment of rheumatic pain and bronchitis. The leaf of the plant consists of Coronalolide, coronalolic acid, Coronalolide methyl ester, ethyl coronalolate acetate triterpenes (secocycloartanes), and so forth. Methanol extract from the leaves of Gardenia coronaria was completely screened for membrane stability and antibacterial activity. The lower concentrations of Methanolic leaf extract of Gardenia coronaria gave good antimicrobial and anti-inflammatory activity, but higher concentrations gave relatively more projecting antibacterial activity in vitro as compared with Kanamycin. The crude drug's anti-inflammatory effects were compared with those of Aspirin as positive control.
CONCLUSIONS:
The Methanolic extracts of Gardenia coronaria leaves possessed a broad spectrum antibacterial activity against a variety of both Gram-negative and Gram-positive organisms like Streptococcus agalactiae, Escherichia coli, Pseudomonas aeruginosa, Bacillus cereus, Shigella sonnei, Shigella boydii, and Proteus mirabilis, with a zone of inhibition from 10 to 16 mm. The extract also showed good membrane stability to be considered as having significant anti-inflammatory action.
Tetrahedron,2004, 60(7):1517-23.
Cytotoxic and anti-HIV-1 constituents from leaves and twigs of Gardenia tubifera[Reference: WebLink]

METHODS AND RESULTS:
Two new natural cycloartanes, tubiferolide methyl ester (1) and tubiferaoctanolide (2), together with the known Coronalolide (3) and Coronalolide methyl ester (4) have been isolated from leaves and twigs of Gardenia tubifera. In addition, a new flavone 5,3',5'-tri-hydroxy-7,4'-dimethoxyflavone (5), five known flavones 6-10 and hexacosyl 4'-hydroxy-trans-cinnamate (11) were also obtained from the same source. The structures were assigned on the basis of spectroscopic methods.
CONCLUSIONS:
Compounds 3, 7, 9, and 10 showed significant cytotoxic activities only in P-388 cell line. Compound 1 was cytotoxic against P-388, KB, Col-2 and Lu-1, while 4 was active in P-388 and BCA-1. Compounds 3 and 4 displayed significant anti-HIV activities in the HIV-1RT assay; compound 7 showed moderate activity in this assay. Compounds 5-10 were also found to be active in the ΔTat/RevMC 99 syncytium assay.
Coronalolide Description
Source: The herbs of Gardenia sootepensis hutchins.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
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IF=14.548(2019)

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ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.0717 mL 10.3584 mL 20.7168 mL 41.4336 mL 51.792 mL
5 mM 0.4143 mL 2.0717 mL 4.1434 mL 8.2867 mL 10.3584 mL
10 mM 0.2072 mL 1.0358 mL 2.0717 mL 4.1434 mL 5.1792 mL
50 mM 0.0414 mL 0.2072 mL 0.4143 mL 0.8287 mL 1.0358 mL
100 mM 0.0207 mL 0.1036 mL 0.2072 mL 0.4143 mL 0.5179 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Tetrahedron,1997,28(18):529-38.
Novel cytotoxic ring-a seco-cycloartane triterpenes from Gardenia coronaria and G. sootepensis[Reference: WebLink]

METHODS AND RESULTS:
Coronalolide methyl ester (1), Coronalolide (2), and coronalolic acid (3) were isolated from the leaves and/or stems of Gardenia coronaria. A further compound, methyl coronalolate acetate (4), was purified from the stems after methylation. The novel compounds 1–4 have the rare ring-A seco-cycloartane carbon skeleton and their structures were assigned on the basis of spectral data and molecular modeling, as well as X-ray crystallography performed on 1.
CONCLUSIONS:
Compounds 1 and 2 were also isolated from the leaves of Gardenia sootepensis and showed broad cytotoxic activity when evaluated against a panel of human cancer cell lines.
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