Science | Nature | Cell | View More
Natural Products
Coronarin D ethyl ether
Coronarin D ethyl ether
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Coronarin D ethyl ether
Price:
CAS No.: 138965-89-6
Catalog No.: CFN99439
Molecular Formula: C22H34O3
Molecular Weight: 346.5 g/mol
Purity: >=98%
Type of Compound: Diterpenoids
Physical Desc.: Powder
Source: The rhizomes of Hedychium coronarium
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Lund University (Sweden)
  • Istanbul University (Turkey)
  • National Hellenic Research Foun... (Greece)
  • University of Eastern Finland (Finland)
  • Universite Libre de Bruxelles (Belgium)
  • CSIRO - Agriculture Flagship (Australia)
  • John Innes Centre (United Kingdom)
  • The Vancouver Prostate Centre (... (Canada)
  • National Cancer Institute (USA)
  • University of Oslo (Norway)
  • University of Illinois (USA)
  • More...
Package
Featured Products
Oleic acid

Catalog No: CFN94800
CAS No: 112-80-1
Price: $30/20mg
Paeoniflorin

Catalog No: CFN99544
CAS No: 23180-57-6
Price: $30/20mg
Astragaloside IV

Catalog No: CFN99171
CAS No: 84687-43-4
Price: $30/20mg
Luteolin-3-O-beta-D-glucuronide

Catalog No: CFN93187
CAS No: 53527-42-7
Price: $238/10mg
Caffeine

Catalog No: CFN99004
CAS No: 58-08-2
Price: $30/20mg
Tricetin

Catalog No: CFN70392
CAS No: 520-31-0
Price: $118/10mg
Cinnamic aldehyde

Catalog No: CFN90321
CAS No: 14371-10-9
Price: $30/20mg
Gallocatechin gallate

Catalog No: CFN96488
CAS No: 5127-64-0
Price: $100/5mg
Arctigenin

Catalog No: CFN99534
CAS No: 7770-78-7
Price: $40/20mg
11-Hydroxy-sugiol

Catalog No: CFN90366
CAS No: 88664-08-8
Price: $490/5mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Coronarin D inhibits NF-KB activation pathway, which leads to inhibition of inflammation, invasion, and osteoclastogenesis, as well as potentiation of apoptosis.It shows promising antifungal activity against C. albicans in vitro.
Targets: NF-KB
In vitro:
Bioorg Med Chem Lett. 2011 Dec 15;21(24):7460-5.
Chemical constituents of the rhizomes of Hedychium coronarium and their inhibitory effect on the pro-inflammatory cytokines production LPS-stimulated in bone marrow-derived dendritic cells.[Pubmed: 22071304]
The rhizomes of Hedychium coronarium have been used for the treatment of inflammation, skin diseases, headache, and sharp pain due to rheumatism in traditional medicine.
METHODS AND RESULTS:
From this plant, three new labdane-type diterpenes 1-3, named coronarins G-I as well as seven known 4-10, coronarin D, coronarin D methyl ether, hedyforrestin C, (E)-nerolidol, β-sitosterol, daucosterol, and stigmasterol were isolated. Their chemical structures were elucidated by mass, 1D- and 2D-nuclear magnetic resonance spectroscopy. They were evaluated for inhibitory effects on lipopolysaccharide-stimulated production of pro-inflammatory cytokines in bone marrow-derived dendritic cells. Among of them, compounds 1, 2, and 6 were significant inhibitors of LPS-stimulated TNF-α, IL-6, and IL-12 p40 productions with IC(50) ranging from 0.19±0.11 to 10.38±2.34 μM. The remains of compounds showed inactivity or due to cytotoxicity.
CONCLUSIONS:
These results warrant further studies concerning the potential anti-inflammatory benefits of labdane-type diterpenes from H. coronarium.
Coronarin D ethyl ether Description
Source: The rhizomes of Hedychium coronarium
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
6'-Feruloylnodakenin

Catalog No: CFN95202
CAS No: 131623-14-8
Price: $318/10mg
Stevioside D

Catalog No: CFN95230
CAS No: 1310055-59-4
Price: $463/5mg
Leachianol F

Catalog No: CFN95147
CAS No: 164123-50-6
Price: $318/5mg
New compound 8

Catalog No: CFN95341
CAS No: N/A
Price: $318/5mg
10-O-trans-p-Feruloylscandoside

Catalog No: CFN95392
CAS No: 1428268-72-7
Price: $318/10mg
(1,5E,11E)-tridecatriene-7,9-diyne...

Catalog No: CFN95161
CAS No: 201012-14-8
Price: $318/10mg
Bergaptol-beta-glucopyranoside

Catalog No: CFN95186
CAS No: 131623-13-7
Price: $318/10mg
Lappaol B

Catalog No: CFN95242
CAS No: 62359-60-8
Price: $333/10mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.886 mL 14.43 mL 28.86 mL 57.7201 mL 72.1501 mL
5 mM 0.5772 mL 2.886 mL 5.772 mL 11.544 mL 14.43 mL
10 mM 0.2886 mL 1.443 mL 2.886 mL 5.772 mL 7.215 mL
50 mM 0.0577 mL 0.2886 mL 0.5772 mL 1.1544 mL 1.443 mL
100 mM 0.0289 mL 0.1443 mL 0.2886 mL 0.5772 mL 0.7215 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Nat Prod Res. 2008;22(14):1249-56.
Labdane diterpenes from the rhizomes of Hedychium coronarium.[Pubmed: 18932088]

METHODS AND RESULTS:
A new labdane diterpenoid, (E)-labda-8(17),12-dien-15,16-olide (1) together with eight known compounds, coronarin D (2), coronarin D methyl ether (3), Coronarin D ethyl ether (4), isocoronarin D (5), coronarin B (6), labda-8(17),11,13-trien-15,16-olide (7), (E)-labda-8(17),12-diene-15,16-dial (8) and 16-hydroxylabda-8(17),11,13-trien-15,16-olide (9), are isolated from the rhizomes of Hedychium coronarium. Compounds 2-4, 5 and 9 are isolated as mixtures of C-15, C-14 and C-16 epimers, respectively.
CONCLUSIONS:
Their structures are determined on the basis of their spectroscopic data. The epimeric mixtures of 2 and 3 have not been reported before. Some of them were evaluated for their cytotoxicity.
Oleic acid

Catalog No: CFN94800
CAS No: 112-80-1
Price: $30/20mg
Paeoniflorin

Catalog No: CFN99544
CAS No: 23180-57-6
Price: $30/20mg
Astragaloside IV

Catalog No: CFN99171
CAS No: 84687-43-4
Price: $30/20mg
Luteolin-3-O-beta-D-glucuronide

Catalog No: CFN93187
CAS No: 53527-42-7
Price: $238/10mg
Caffeine

Catalog No: CFN99004
CAS No: 58-08-2
Price: $30/20mg
Tricetin

Catalog No: CFN70392
CAS No: 520-31-0
Price: $118/10mg
Cinnamic aldehyde

Catalog No: CFN90321
CAS No: 14371-10-9
Price: $30/20mg
Gallocatechin gallate

Catalog No: CFN96488
CAS No: 5127-64-0
Price: $100/5mg
Arctigenin

Catalog No: CFN99534
CAS No: 7770-78-7
Price: $40/20mg
11-Hydroxy-sugiol

Catalog No: CFN90366
CAS No: 88664-08-8
Price: $490/5mg
Tags: buy Coronarin D ethyl ether | Coronarin D ethyl ether supplier | purchase Coronarin D ethyl ether | Coronarin D ethyl ether cost | Coronarin D ethyl ether manufacturer | order Coronarin D ethyl ether | Coronarin D ethyl ether distributor