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Cyclo(Leu-Leu)
Cyclo(Leu-Leu)
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cyclo(Leu-Leu)
Price: $238 / 10mg
CAS No.: 1436-27-7
Catalog No.: CFN90288
Molecular Formula: C12H22N2O2
Molecular Weight: 226.32 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: From Pantoea agglomerans
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF    Manual
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $99.2 / In-stock
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cyclo(Leu-Leu) is an efficient supramolecular catalyst.
Cyclo(Leu-Leu) Description
Source: From Pantoea agglomerans
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.4185 mL 22.0926 mL 44.1852 mL 88.3704 mL 110.4631 mL
5 mM 0.8837 mL 4.4185 mL 8.837 mL 17.6741 mL 22.0926 mL
10 mM 0.4419 mL 2.2093 mL 4.4185 mL 8.837 mL 11.0463 mL
50 mM 0.0884 mL 0.4419 mL 0.8837 mL 1.7674 mL 2.2093 mL
100 mM 0.0442 mL 0.2209 mL 0.4419 mL 0.8837 mL 1.1046 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
Supramolecular Chemistry, 2017,29(5):330- 49.
Interfacial supramolecular biomimetic epoxidation catalysed by cyclic dipeptides[Reference: WebLink]

METHODS AND RESULTS:
We synthesised a library of cis- and trans-cyclic dipeptides and evaluated their efficacy as catalysts in the asymmetric Weitz-Scheffer epoxidation of trans-chalcone. A thorough investigation relying on structure-activity studies and computational studies provided insights into the mechanism of the process. Our results revealed some structural features required for efficient conversion and for introduction of chirality into the product. The cyclic dipeptide acts as a catalyst by templating a supramolecular arrangement at the aqueous-organic interface required for efficient transformations to occur.
CONCLUSIONS:
Among all cyclic dipeptides investigated, Cyclo(Leu-Leu) was the most efficient supramolecular catalyst.
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L-Nicotine

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Price: $40/20mg
Loganin

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Mangiferin

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Price: $40/20mg
Senkirkine

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Ophiopogonin D

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Price: $248/20mg
8-Acetoxypinoresinol

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Morroniside

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Price: $50/20mg
Quercetin 3-O-malonylglucoside

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Price: $238/5mg
3',4',5'-Trimethoxyflavone

Catalog No: CFN70439
CAS No: 67858-30-4
Price: $118/10mg
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