Cyclo(Tyr-Phe) | CAS:5147-17-1 | Manufacturer ChemFaces

Cyclo(Tyr-Phe)

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Description:

Cyclo-(Phe-Tyr) shows anticoagulant activities.

In vitro:

Chinese Traditional Patent Medicine, 2015,37 (1): 34-9.

Anticoagulant activity of cyclic dipeptides from Sparganii Rhizome[Reference: WebLink]

To study the in vitro anticoagulant activity of cyclodipeptide( cyclo-( Tyr-Leu),cyclo-( PhePhe) and cyclo-( Phe-Tyr)) isolated from Sparganium stoloniferum Buch.-Ham.
METHODS AND RESULTS:
The special kits were used to measure anticoagulant activity with platelet poor plasma collected from abdominal aorta of male SD rats,including prothrombin time( PT),activated partial thromboplastin time( APTT) and thrombin time( TT).PT,APTT,TT were prolonged by the addition of cyclo-( Tyr-Leu),cyclo-( Phe-Phe) and Cyclo(Tyr-Phe). The former two presented no dose-effect relationship but the latter did.
CONCLUSIONS:
Of three cyclodipeptides from S. stoloniferum,all the three show anticoagulant activities with cyclo-( Phe-Tyr) being by far the most effective.

Cyclo(Tyr-Phe) Description

Source:	From Brevibacillus borstelensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Cyclo(Tyr-Phe)
Price:	$238 / 10mg
CAS No.:	5147-17-1
Catalog No.:	CFN90278
Molecular Formula:	C₁₈H₁₈N₂O₃
Molecular Weight:	310.35 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	From Brevibacillus borstelensis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticoagulants Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2222 mL	16.1108 mL	32.2217 mL	64.4434 mL	80.5542 mL
5 mM	0.6444 mL	3.2222 mL	6.4443 mL	12.8887 mL	16.1108 mL
10 mM	0.3222 mL	1.6111 mL	3.2222 mL	6.4443 mL	8.0554 mL
50 mM	0.0644 mL	0.3222 mL	0.6444 mL	1.2889 mL	1.6111 mL
100 mM	0.0322 mL	0.1611 mL	0.3222 mL	0.6444 mL	0.8055 mL

CFN96110	Cyclo(D-Phe-L-Pro)	26488-24-4	244.3	C₁₄H₁₆N₂O₂
CFN96129	Cyclo(L-Phe-L-Pro)	3705-26-8	244.3	C₁₄H₁₆N₂O₂
CFN90276	Cyclo(Tyr-Pro)	5654-84-2	260.29	C₁₄H₁₆N₂O₃
CFN90278	Cyclo(Tyr-Phe)	5147-17-1	310.35	C₁₈H₁₈N₂O₃
CFN89034	3,6-Dibenzyl-2-hydroxy-5-methoxypyrazine	132213-65-1	306.36	C₁₉H₁₈N₂O₂
CFN96983	Emeheterone	117333-12-7	322.36	C₁₉H₁₈N₂O₃
CFN90280	Cyclo(Phe-Hpro)	1016899-94-7	260.30	C₁₄H₁₆N₂O₃
CFN90279	Cyclo(Tyr-Hpro)	813461-21-1	276.29	C₁₄H₁₆N₂O₄
CFN90277	Cyclo(Pro-Trp)	67889-75-2	283.33	C₁₆H₁₇N₃O₂
CFN96937	Demethoxyfumitremorgin C	111768-16-2	349.43	C₂₁H₂₃N₃O₂