Cyclocommunol | CAS:145643-96-5 | Manufacturer ChemFaces

Cyclocommunol

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Cyclocommunol exhibits cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines. It also shows strong inhibition of arachidonic acid (AA)- and collagen-induced platelet aggregation.

Targets:

PAFR

In vitro:

J Asian Nat Prod Res. 2010 Jul;12(7):586-92.

New isoprenylated flavonoids and cytotoxic constituents from Artocarpus tonkinensis.[Pubmed: 20628938]

METHODS AND RESULTS:
Two new isoprenylated flavonoids, artotonins A and B (1 and 2), along with 13 known compounds (3-15), were isolated from the roots of Artocarpus tonkinensis A. Chev. ex Gagnep. The structures were elucidated by spectroscopic methods.
CONCLUSIONS:
Cyclocommunol (6), isocyclomulberrin (7), cudraflavone C (11), and morusin (13) exhibited cytotoxicity against hepatocellular carcinoma (SMMC-7721) and gastric carcinoma (BGC-823 and SGC-7901) cell lines.

Biochem Pharmacol. 1993 Jan 26;45(2):509-12.

Antiplatelet activity of some prenylflavonoids.[Pubmed: 8435100]

Eight naturally occurring prenylflavonoids were tested for their antiplatelet activities in rabbit platelet suspension.
METHODS AND RESULTS:
Cyclomorusin and artomunoxanthone showed strong inhibition of platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) induced platelet aggregation. Cyclomulberrin, dihydroisocycloartomunin, Cyclocommunol and cyclocommunin showed strong inhibition of arachidonic acid (AA)- and collagen-induced platelet aggregation. Cyclomorusin also inhibited markedly collagen-induced platelet aggregation. Cyclocommunin, dihydroisocycloartomunin and cyclomulberrin also showed slight but significant antiplatelet effects on the aggregation induced by PAF.
CONCLUSIONS:
Of the compounds tested, cyclocommunin exhibited the most potent inhibition of platelet aggregation induced by collagen (IC50 = 14.4 microM) and AA (IC50 = 12.5 microM). Thromboxane B2 formation caused by AA was suppressed by cyclocommunin and artomunoxanthone.

Cyclocommunol Description

Source:	The root barks of Morus alba L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Cyclocommunol
Price:
CAS No.:	145643-96-5
Catalog No.:	CFN92418
Molecular Formula:	C₂₀H₁₆O₆
Molecular Weight:	352.3 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow cryst.
Source:	The root barks of Morus alba L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Anti-platelet aggregation Compound Library Flavonoids Compound Library PAFR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.8385 mL	14.1924 mL	28.3849 mL	56.7698 mL	70.9622 mL
5 mM	0.5677 mL	2.8385 mL	5.677 mL	11.354 mL	14.1924 mL
10 mM	0.2838 mL	1.4192 mL	2.8385 mL	5.677 mL	7.0962 mL
50 mM	0.0568 mL	0.2838 mL	0.5677 mL	1.1354 mL	1.4192 mL
100 mM	0.0284 mL	0.1419 mL	0.2838 mL	0.5677 mL	0.7096 mL

CFN92418	Cyclocommunol	145643-96-5	352.3	C₂₀H₁₆O₆
CFN92417	Cyclomulberrin	19275-51-5	420.5	C₂₅H₂₄O₆
CFN97714	Cyclomorusin	62596-34-3	418.45	C₂₅H₂₂O₆
CFN92694	Neocyclomorusin	62596-35-4	436.5	C₂₅H₂₄O₇
CFN99273	Artoheterophyllin B	1174017-37-8	504.6	C₃₀H₃₂O₇
CFN97748	Cycloheterophyllin	36545-53-6	502.56	C₃₀H₃₀O₇