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Cyclomusalenone
Cyclomusalenone
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Cyclomusalenone
Price:
CAS No.: 30452-60-9
Catalog No.: CFN97763
Molecular Formula: C30H48O
Molecular Weight: 424.71 g/mol
Purity: >=98%
Type of Compound: Triterpenoids
Physical Desc.: Powder
Source: The herbs of Musa sapientum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Cyclomusalenone is a potent α-glucosidase inhibitor.
Targets: α-glucosidase
Cyclomusalenone Description
Source: The herbs of Musa sapientum
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

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After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals
More...

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3545 mL 11.7727 mL 23.5455 mL 47.091 mL 58.8637 mL
5 mM 0.4709 mL 2.3545 mL 4.7091 mL 9.4182 mL 11.7727 mL
10 mM 0.2355 mL 1.1773 mL 2.3545 mL 4.7091 mL 5.8864 mL
50 mM 0.0471 mL 0.2355 mL 0.4709 mL 0.9418 mL 1.1773 mL
100 mM 0.0235 mL 0.1177 mL 0.2355 mL 0.4709 mL 0.5886 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Medicinal Chemistry Research. 2015 May;24(5):2177-2182.
Synthesis and evaluation of 29-norcycloartane triterpenoids as α-glucosidase inhibitors.[Reference: WebLink]

METHODS AND RESULTS:
A series of oxygen and nitrogen derivatives of 29-norcycloartane triterpenoids have been synthesized on the basis of Cyclomusalenone isolated from Musa balbisiana Colla. The structures of new compounds have been established by an NMR spectroscopy analysis, and inhibitory activity against α-glucosidase was evaluated.
CONCLUSIONS:
Among tested compounds, 2,3-isoxazoloCyclomusalenone is discovered as a new potent α-glucosidase inhibitor with IC50 value 20.4 μM being 30- and 20-fold more active than initial Cyclomusalenone and marketed drug acarbose.
Structure Identification:
Chemical & pharmaceutical bulletin.1997 Apr15; 45(4):744-746.
4-Epicycloeucalenone and 4-Epicyclomusalenone : Two 3-Oxo-28-norcycloartanes from the Fruit Peel of Musa sapientum L.[Reference: WebLink]

METHODS AND RESULTS:
Two 3-oxo-28-norcycloartane-type triterpenes, 4-epicycloeucalenone and 4-epiCyclomusalenone, and two known 3-oxo-29-norcycloartanes, cycloeucalenone and Cyclomusalenone, were isolated from the n-hexane extract of the fruit peel of Musa sapientum L. (banana). The structures of the 28-norcycloartanes were determined by spectroscopic and chemical methods.
CFN97994Cycloartanol4657-58-3428.7C30H52O
CFN9949624-Methylenecycloartan-3-ol1449-09-8440.8 C31H52O
CFN9937024-Methylenecycloartanol acetate1259-94-5482.8 C33H54O2
CFN9177824-Methylene cycloartanyl ferulate469-36-3616.91C41H60O4
CFN9694124-Methylenecycloartanone1449-08-7438.74C31H50O
CFN9787824-Methylenecycloartane-3beta,26-diol17020-27-8456.8C31H52O2
CFN9807423-deoxojessic acid215609-93-1486.7 C31H50O4
CFN996191-Dehydroxy-23-deoxojessic acid149252-87-9470.7 C31H50O3
CFN98701Cycloeucalenol469-39-6426.7 C30H50O
CFN97763Cyclomusalenone30452-60-9424.71C30H48O
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