Deoxyvasicinone | CAS:530-53-0 | Manufacturer ChemFaces

Deoxyvasicinone

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Description:

Deoxyvasicinone derivatives can be considered as promising lead molecules for the development of more potent inhibitors of NEDD8-activating enzyme.

In vitro:

Methods. 2015 Jan;71:71-6.

Discovery of deoxyvasicinone derivatives as inhibitors of NEDD8-activating enzyme.[Pubmed: 25196325]

NEDD8-activating enzyme (NAE) controls the specific degradation of proteins regulated by cullin-RING ubiquitin E3 ligases, and has been considered as an attractive molecular target for the development of drugs against cancer.
METHODS AND RESULTS:
A pharmacophore model constructed from a training set of Deoxyvasicinone derivatives was used to screen 376 compounds from an analogue database. From the initial screening, the valine-linked Deoxyvasicinone derivative 9 and the N-isopropyl-linked Deoxyvasicinone derivative 10 emerged as the top scoring candidates. Compounds 9 and 10 showed micromolar potencies in both cell-free and cell-based systems, with selectivity for NAE over the related enzymes SAE and UAE. Molecular modelling analysis suggested that 9 and 10 may inhibit NAE by blocking the ATP-binding domain.
CONCLUSIONS:
Thus, these Deoxyvasicinone derivatives could be considered as promising lead molecules for the development of more potent inhibitors of NAE.

Deoxyvasicinone Description

Source:	The herbs of Galium aparine L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Deoxyvasicinone
Price:
CAS No.:	530-53-0
Catalog No.:	CFN98882
Molecular Formula:	C₁₁H₁₀N₂O
Molecular Weight:	186.2 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Galium aparine L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Precursors Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	5.3706 mL	26.8528 mL	53.7057 mL	107.4114 mL	134.2642 mL
5 mM	1.0741 mL	5.3706 mL	10.7411 mL	21.4823 mL	26.8528 mL
10 mM	0.5371 mL	2.6853 mL	5.3706 mL	10.7411 mL	13.4264 mL
50 mM	0.1074 mL	0.5371 mL	1.0741 mL	2.1482 mL	2.6853 mL
100 mM	0.0537 mL	0.2685 mL	0.5371 mL	1.0741 mL	1.3426 mL

CFN92302	Febrifugine	24159-07-7	301.3	C₁₆H₁₉N₃O₃
CFN92303	Isofebrifugine	32434-44-9	301.3	C₁₆H₁₉N₃O₃
CFN91939	Desoxypeganine	495-59-0	172.23	C₁₁H₁₂N₂
CFN97052	Vasicine	6159-55-3	188.2	C₁₁H₁₂N₂O
CFN99009	Vasicinol	5081-51-6	204.2	C₁₁H₁₂N₂O₂
CFN98882	Deoxyvasicinone	530-53-0	186.2	C₁₁H₁₀N₂O
CFN98773	Vasicinone	486-64-6	202.2	C₁₁H₁₀N₂O₂
CFN97406	Vasicinolone	84847-50-7	218.2	C₁₁H₁₀N₂O₃
CFN98889	Coixol	532-91-2	165.1	C₈H₇NO₃
CFN97184	2,7-Dihydroxy-2H-1,4-benzoxazin-3(4H)-one	69804-59-7	181.1	C₈H₇NO₄