Derrone | CAS:76166-59-1 | Manufacturer ChemFaces

Derrone

ChemFaces products have been cited in many studies from excellent and top scientific journals

Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC

How to Order

Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com

Delivery time

Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal

Citing Use of our Products

More Impact Factor than five Cite...

* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.

According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

Our products had been exported to the following research institutions and universities, And still growing.

Subang Jaya Medical Centre (Malaysia)
Harvard University (USA)
Monash University Sunway Campus (Malaysia)
Florida A&M University (USA)

Korea Intitute of Science and T... (Korea)
Celltrion Chemical Research Ins... (Korea)
University of Zurich (Switzerland)
Anna University (India)

Biotech R&D Institute (USA)
Funda??o Universitária de Dese... (Brazil)
Heinrich-Heine-University Düss... (Germany)
More...

Package

Featured Products

More...

6,8-Diprenylgenistein

Catalog No: CFN97935
CAS No: 51225-28-6
Price: $ / mg

Martynoside

Catalog No: CFN97159
CAS No: 67884-12-2
Price: $338/5mg

Guaijaverin

Catalog No: CFN98211
CAS No: 22255-13-6
Price: $138/20mg

Alpinumisoflavone

Catalog No: CFN98440
CAS No: 34086-50-5
Price: $ /

Eriocitrin

Catalog No: CFN99718
CAS No: 13463-28-0
Price: $80/20mg

Fangchinoline

Catalog No: CFN99167
CAS No: 436-77-1
Price: $40/20mg

4-Hydroxybenzoic acid

Catalog No: CFN97577
CAS No: 99-96-7
Price: $30/20mg

Vicenin -3

Catalog No: CFN92032
CAS No: 59914-91-9
Price: $198/20mg

Ganoderic acid B

Catalog No: CFN92052
CAS No: 81907-61-1
Price: $288/20mg

Sesamoside

Catalog No: CFN99274
CAS No: 117479-87-5
Price: $100/20mg

Description:

Derrone may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens. It is also a novel Aurora kinase inhibitor, it can significantly inhibit the formation and growth of MCF7 tumor spheroids.

Targets:

Antifection

In vitro:

Molecules. 2012 Jun 13;17(6):7284-93.

Antibacterial, antifungal and cytotoxic activities of two flavonoids from Retama raetam flowers.[Pubmed: 22695233]

METHODS AND RESULTS:
The compounds licoflavone C (1) and Derrone (2) were active against Pseudomonas aeruginosa and Escherichia coli (7.81-15.62 μg/mL) and showed important antifungal activity. Strong antifungal activity against Candida species (7.81 μg/mL) was for example found with Derrone. The tested compounds also showed strong cytotoxicity against Hep-2 cells.
CONCLUSIONS:
Derrone may be interesting antimicrobial agents to be used against infectious diseases caused by many pathogens.

Biol Pharm Bull. 2016 Jun 1;39(6):935-45.

In Vitro Characterization of Derrone as an Aurora Kinase Inhibitor.[Pubmed: 26983907 ]

Among mitotic kinases, Aurora kinases are the most widely studied, since their expression is restricted to mitosis. They play a key role in chromosome segregation and cell polyploidy. Aurora kinases are important therapeutic targets, and several research groups have directed their efforts toward the identification of kinase inhibitors. The aim of this study is to screen and characterize Aurora kinase inhibitors from natural substances extracted from plants that are used in the Vietnamese pharmacopoeia.
METHODS AND RESULTS:
We have characterized in vitro Derrone, extracted from Erythrina orientalis L. MURR, as a novel Aurora kinase inhibitor. This compound exhibited an ability to inhibit the phosphorylation of histone H3 at ser10 both in kinase assay and at the cellular level. The compound was more effective against Aurora kinase B, with a lower IC50 value as compared to Aurora A. Moreover, it impaired the mitotic spindle checkpoint and led to endoreduplication in cancer cells, a phenomenon caused by an Aurora B inhibitor.
CONCLUSIONS:
Interestingly, using the xCelligence system and real-time cell analysis (RTCA) software, we set up a comparison of cell proliferation profiles between cancer cells treated with Derrone and VX680-a well-known Aurora kinase inhibitor-and we found that these profiles exhibited considerable similarity in cell morphology, growth, and death. Additionally, Derrone significantly inhibited the formation and growth of MCF7 tumor spheroids.

Derrone Description

Source:	The herbs of Cudrania tricuspidata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Derrone
Price:
CAS No.:	76166-59-1
Catalog No.:	CFN97689
Molecular Formula:	C₂₀H₁₆O₅
Molecular Weight:	336.34 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Yellow powder
Source:	The herbs of Cudrania tricuspidata
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Inhibitors Compound Library Antibacterial Compound Library Flavonoids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.9732 mL	14.8659 mL	29.7318 mL	59.4636 mL	74.3295 mL
5 mM	0.5946 mL	2.9732 mL	5.9464 mL	11.8927 mL	14.8659 mL
10 mM	0.2973 mL	1.4866 mL	2.9732 mL	5.9464 mL	7.433 mL
50 mM	0.0595 mL	0.2973 mL	0.5946 mL	1.1893 mL	1.4866 mL
100 mM	0.0297 mL	0.1487 mL	0.2973 mL	0.5946 mL	0.7433 mL

CFN97827	8-Prenyldaidzein	135384-00-8	322.36	C₂₀H₁₈O₄
CFN96146	Lupiwighteone	104691-86-3	338.4	C₂₀H₁₈O₅
CFN97689	Derrone	76166-59-1	336.34	C₂₀H₁₆O₅
CFN97883	Gancaonin M	129145-51-3	352.4	C₂₁H₂₀O₅
CFN97223	2,3-Dehydrokievitone	74161-25-4	354.4	C₂₀H₁₈O₆
CFN96208	Toxicarolisoflavone	3044-60-8	410.4	C₂₃H₂₂O₇
CFN99817	Ficusin A	173429-83-9	404.5	C₂₅H₂₄O₅