Dihydrocholesterol | CAS:80-97-7 | Manufacturer ChemFaces

Dihydrocholesterol

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Description:

Dihydrocholesterol is a cholesterol derivative found in human feces, gallstones, eggs, and other biological matter. Dihydrocholesterol is equally effective in reducing plasma cholesterol as β-sitosterol at a low dose, which is mediated by inhibiting the cholesterol absorption and increasing the fecal sterol excretion.

In vivo:

Br J Exp Pathol. 1979 Jun;60(3):231-8.

Dihydrocholesterol-induced gallstones in the rabbit: evidence that bile acids cause gallbladder epithelial injury.[Pubmed: 383127]

Rabbits fed a diet containing 0.75% Dihydrocholesterol for 7 days develop bile acid allodeoxycholic (ADCA) and deoxycholic acid (DCA) stones in the gallbladder.
METHODS AND RESULTS:
In this model, inflammatory changes in the gallbladder mucosa are often observed even before stones are formed. Within 3 days of the lithogenic diet, abnormalities of platelet function were detectable. Platelet aggregation upon addition of adenosine diphosphate (ADP) was impaired. At the same time the red cells became crenated and developed thorny spicules (echinocytes). This morphological changes was associated with intracellular dehydration and excessive loss of potassium. These changes coincided with a rise in serum ADCA and DCA and preceded a slow rise in serum cholesterol. In vitro incubation studies also suggested that the bile acids had probably caused membrane injury to the platelets and red cells.
CONCLUSIONS:
It is concluded that changes in the bile ADCA and DCA probably induce gallbladder epithelial injury in this model of experimental cholelithiasis.

Atherosclerosis. 2015 Sep;242(1):77-86.

Plasma cholesterol-lowering activity of dietary dihydrocholesterol in hypercholesterolemia hamsters.[Pubmed: 26184696 ]

Cholesterol analogs have been used to treat hypercholesterolemia. The present study was to examine the effect of Dihydrocholesterol (DC) on plasma total cholesterol (TC) compared with that of β-sitosterol (SI) in hamsters fed a high cholesterol diet.
METHODS AND RESULTS:
Forty-five male hamsters were randomly divided into 6 groups, fed either a non-cholesterol diet (NCD) or one of five high-cholesterol diets without addition of DC and SI (HCD) or with addition of 0.2% DC (DA), 0.3% DC (DB), 0.2% SI (SA), and 0.3% SI (SB), respectively, for 6 weeks. Results showed that DC added into diet at a dose of 0.2% could reduce plasma TC by 21%, comparable to that of SI (19%). At a higher dose of 0.3%, DC reduced plasma TC by 15%, less effective than SI (32%). Both DC and SI could increase the excretion of fecal sterols, however, DC was more effective in increasing the excretion of neutral sterols but it was less effective in increasing the excretion of acidic sterols compared with SI. Results on the incorporation of sterols in micellar solutions clearly demonstrated both DC and SI could displace the cholesterol from micelles with the former being more effective than the latter.
CONCLUSIONS:
DC was equally effective in reducing plasma cholesterol as SI at a low dose. Plasma TC-lowering activity of DC was mediated by inhibiting the cholesterol absorption and increasing the fecal sterol excretion.

Dihydrocholesterol Description

Source:	The testes of White Carneau pigeons.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Dihydrocholesterol
Price:	$70 / 20mg
CAS No.:	80-97-7
Catalog No.:	CFN90608
Molecular Formula:	C₂₇H₄₈O
Molecular Weight:	388.67 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The testes of White Carneau pigeons.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-hyperlipidemic Compound Library Steroids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.5729 mL	12.8644 mL	25.7288 mL	51.4575 mL	64.3219 mL
5 mM	0.5146 mL	2.5729 mL	5.1458 mL	10.2915 mL	12.8644 mL
10 mM	0.2573 mL	1.2864 mL	2.5729 mL	5.1458 mL	6.4322 mL
50 mM	0.0515 mL	0.2573 mL	0.5146 mL	1.0292 mL	1.2864 mL
100 mM	0.0257 mL	0.1286 mL	0.2573 mL	0.5146 mL	0.6432 mL

CFN93571	25S-Inokosterone	19595-18-7	480.6	C₂₇H₄₄O₇
CFN93572	25R-Inokosterone	19682-38-3	480.6	C₂₇H₄₄O₇
CFN90217	Turkesterone	41451-87-0	496.64	C₂₇H₄₄O₈
CFN90487	Ecdysone	3604-87-3	464.63	C₂₇H₄₄O₆
CFN90522	Rhapontisterone B	698975-64-3	480.63	C₂₇H₄₄O₇
CFN98873	20-Hydroxyecdysone	5289-74-7	480.6	C₂₇H₄₄O₇
CFN89545	Polypodine B	18069-14-2	496.63	C₂₇H₄₄O₈
CFN98229	Ecdysterone 20,22-monoacetonide	22798-96-5	520.7	C₃₀H₄₈O₇
CFN98230	Ecdysterone 2,3:20,22-diacetonide	22798-98-7	560.8	C₃₃H₅₂O₇
CFN90027	Vitamin D3	67-97-0	384.64	C₂₇H₄₄O