Dihydroprehelminthosporol | CAS:118069-95-7

Dihydroprehelminthosporol

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Product Name	Dihydroprehelminthosporol
Price:
CAS No.:	118069-95-7
Catalog No.:	CFN96986
Molecular Formula:	C₁₅H₂₆O₂
Molecular Weight:	238.37 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Oil
Source:	The culture filtrates of a Bipolaris species pathogenic to Johnson grass.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Dihydroprehelminthosporol is a strongly phytotoxic metabolite, it exhibits cytotoxicity towards two human cancer cell lines, A549 and SK-OA-3.

In vitro:

Chemistry of Natural Compounds, 2015, 51(2):270-272.

Chemical Constituents of the Fungus Veronaea sp.[Reference: WebLink]

METHODS AND RESULTS:
A new compound, isoDihydroprehelminthosporol (1), and five known compounds, Dihydroprehelminthosporol (2), 4-(2-hydroxyethyl)phenol (3), anhydrocochlioquinone A (4), isocochlioquinone A (5), and cochlioquinone A (6), were isolated from the fungus Veronaea sp. 1.03621. Their structures were elucidated using spectroscopic methods, mainly 1 D and 2 D NMR.
CONCLUSIONS:
These compounds were tested for their cytotoxicity towards two human cancer cell lines, A549 and SK-OA-3, and exhibited different activity.

Dihydroprehelminthosporol Description

Source:	The culture filtrates of a Bipolaris species pathogenic to Johnson grass.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

J Nat Prod. 1988 Sep;51(5):821-8.

Toxins from weed pathogens, I. Phytotoxins from a bipolaris pathogen of johnson grass.[Reference: WebLink]

METHODS AND RESULTS:
Two strongly phytotoxic metabolites, prehelminthosporol [1] and Dihydroprehelminthosporol [4], have been isolated from culture filtrates of a Bipolaris species pathogenic to Johnson grass. Prehelminthosporol [1] occurs naturally as a mixture of epimers. The isomers have been separated as the corresponding acetyl derivatives, and the stereochemistry at the hemiacetal carbon has been determined by nOe experiments.
CONCLUSIONS:
Four other structurally related sesquiterpenes, helminthosporal acid [6], helminthosporol [8], helminthosporic acid [9], and isosativenediol [10], were also isolated but showed no significant activity.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Cytotoxic Compound Library Phytotoxic Compound Library Sesquiterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.1952 mL	20.9758 mL	41.9516 mL	83.9032 mL	104.879 mL
5 mM	0.839 mL	4.1952 mL	8.3903 mL	16.7806 mL	20.9758 mL
10 mM	0.4195 mL	2.0976 mL	4.1952 mL	8.3903 mL	10.4879 mL
50 mM	0.0839 mL	0.4195 mL	0.839 mL	1.6781 mL	2.0976 mL
100 mM	0.042 mL	0.2098 mL	0.4195 mL	0.839 mL	1.0488 mL

CFN89167	Isosativenediol	57079-92-2	236.35	C₁₅H₂₄O₂
CFN96986	Dihydroprehelminthosporol	118069-95-7	238.37	C₁₅H₂₆O₂
CFN96987	Prehelminthosporolactone	118101-72-7	234.33	C₁₅H₂₂O₂
CFN89156	Prehelminthosporol	1619-13-2	236.35	C₁₅H₂₄O₂
CFN96670	Sorokinianin	162616-73-1	308.42	C₁₈H₂₈O₄
CFN96681	Secolongifolenediol	53587-37-4	238.37	C₁₅H₂₆O₂
CFN89278	Drechslerine A	405157-84-8	224.34	C₁₄H₂₄O₂
CFN89215	Drechslerine D	405157-88-2	250.33	C₁₅H₂₂O₃