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Dihydroprehelminthosporol
Dihydroprehelminthosporol
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Dihydroprehelminthosporol
Price:
CAS No.: 118069-95-7
Catalog No.: CFN96986
Molecular Formula: C15H26O2
Molecular Weight: 238.37 g/mol
Purity: >=98%
Type of Compound: Sesquiterpenoids
Physical Desc.: Oil
Source: The culture filtrates of a Bipolaris species pathogenic to Johnson grass.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Dihydroprehelminthosporol is a strongly phytotoxic metabolite, it exhibits cytotoxicity towards two human cancer cell lines, A549 and SK-OA-3.
In vitro:
Chemistry of Natural Compounds, 2015, 51(2):270-272.
Chemical Constituents of the Fungus Veronaea sp.[Reference: WebLink]

METHODS AND RESULTS:
A new compound, isoDihydroprehelminthosporol (1), and five known compounds, Dihydroprehelminthosporol (2), 4-(2-hydroxyethyl)phenol (3), anhydrocochlioquinone A (4), isocochlioquinone A (5), and cochlioquinone A (6), were isolated from the fungus Veronaea sp. 1.03621. Their structures were elucidated using spectroscopic methods, mainly 1 D and 2 D NMR.
CONCLUSIONS:
These compounds were tested for their cytotoxicity towards two human cancer cell lines, A549 and SK-OA-3, and exhibited different activity.
Dihydroprehelminthosporol Description
Source: The culture filtrates of a Bipolaris species pathogenic to Johnson grass.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 4.1952 mL 20.9758 mL 41.9516 mL 83.9032 mL 104.879 mL
5 mM 0.839 mL 4.1952 mL 8.3903 mL 16.7806 mL 20.9758 mL
10 mM 0.4195 mL 2.0976 mL 4.1952 mL 8.3903 mL 10.4879 mL
50 mM 0.0839 mL 0.4195 mL 0.839 mL 1.6781 mL 2.0976 mL
100 mM 0.042 mL 0.2098 mL 0.4195 mL 0.839 mL 1.0488 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Nat Prod. 1988 Sep;51(5):821-8.
Toxins from weed pathogens, I. Phytotoxins from a bipolaris pathogen of johnson grass.[Reference: WebLink]

METHODS AND RESULTS:
Two strongly phytotoxic metabolites, prehelminthosporol [1] and Dihydroprehelminthosporol [4], have been isolated from culture filtrates of a Bipolaris species pathogenic to Johnson grass. Prehelminthosporol [1] occurs naturally as a mixture of epimers. The isomers have been separated as the corresponding acetyl derivatives, and the stereochemistry at the hemiacetal carbon has been determined by nOe experiments.
CONCLUSIONS:
Four other structurally related sesquiterpenes, helminthosporal acid [6], helminthosporol [8], helminthosporic acid [9], and isosativenediol [10], were also isolated but showed no significant activity.
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