Episappanol | CAS:111254-18-3 | Manufacturer ChemFaces

Episappanol

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Description:

Episappanol has anti-inflammatory activity , it can significantly inhibit the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α).

Targets:

TNF-α | IL Receptor

In vitro:

Food Funct. 2016 Mar;7(3):1671-9.

Compounds from Caesalpinia sappan with anti-inflammatory properties in macrophages and chondrocytes.[Pubmed: 26951869]

The heartwood of Caesalpinia sappan is a traditional ingredient of food and beverages in South East Asia and has been used in traditional medicine as an analgesic and anti-inflammatory drug or to promote blood circulation. Scientific studies have confirmed different bioactivities associated with its use.
METHODS AND RESULTS:
Here, five fractions were isolated from the ethanolic extract of C. sappan heartwood, including Episappanol (1), protosappanin C (2), brazilin (3), (iso-)protosappanin B (4) and sappanol (5) using high-performance liquid chromatography (HPLC). All compounds were tested for their anti-inflammatory effects in two different cell lines. Cytokine concentrations in the cell supernatant were determined using enzyme-linked immunosorbent assay (ELISA), and mRNA levels were measured using reverse-transcription quantitative polymerase chain reaction (RT-qPCR). In lipopolysaccharide-stimulated macrophages, all compounds significantly inhibited the secretion of the pro-inflammatory cytokines interleukin (IL-6) and tumor necrosis factor-alpha (TNF-α). Sappanol (5) increased the secretion of the anti-inflammatory IL-10. In IL-1β-stimulated chondrocytes, all fractions reduced the mRNA expression and the secretion of the pro-inflammatory cytokines IL-6 and TNF-α. The highest anti-inflammatory effect was found for brazilin (3) in both cell lines. Of note, this is the first study which shows the anti-inflammatory effect of sappanol and Episappanol.
CONCLUSIONS:
This study provides evidence for the efficacy of the traditional use of C. sappan as an anti-inflammatory remedy. Given the high prevalence of inflammation-related pathologies including arthritis, and the urgent need to clinically intervene with these diseases, the anti-inflammatory activity of diverse compounds from C. sappan may be of interest for the development of complementary and alternative treatment strategies.

Episappanol Description

Source:	The heartwoods of Caesalpinia sappan Linn
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Episappanol
Price:
CAS No.:	111254-18-3
Catalog No.:	CFN92962
Molecular Formula:	C₁₆H₁₆O₆
Molecular Weight:	304.29 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The heartwoods of Caesalpinia sappan Linn
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library TNF-α Inhibitor Library IL Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.2863 mL	16.4317 mL	32.8634 mL	65.7268 mL	82.1585 mL
5 mM	0.6573 mL	3.2863 mL	6.5727 mL	13.1454 mL	16.4317 mL
10 mM	0.3286 mL	1.6432 mL	3.2863 mL	6.5727 mL	8.2158 mL
50 mM	0.0657 mL	0.3286 mL	0.6573 mL	1.3145 mL	1.6432 mL
100 mM	0.0329 mL	0.1643 mL	0.3286 mL	0.6573 mL	0.8216 mL

CFN98869	Scillascillin	52706-07-7	312.3	C₁₇H₁₂O₆
CFN99209	7,3',4'-Trihydroxy-3-benzyl-2H-chromene	1111897-60-9	270.3	C₁₆H₁₄O₄
CFN92962	Episappanol	111254-18-3	304.29	C₁₆H₁₆O₆
CFN92769	4-O-Methylepisappanol	112529-37-0	318.3	C₁₇H₁₈O₆
CFN92771	3'-Deoxy-4-O-methylepisappanol	1052714-12-1	302.3	C₁₇H₁₈O₅
CFN92832	Sappanol	111254-19-4	304.3	C₁₆H₁₆O₆
CFN99068	4-O-Methylsappanol	104778-16-7	318.3	C₁₇H₁₈O₆
CFN92770	3'-Deoxy-4-O-methylsappanol	112408-68-1	302.3	C₁₇H₁₈O₅
CFN92964	Sappanone B	104778-15-6	302.28	C₁₆H₁₄O₆
CFN98844	2-Hydroxy-7-O-methylscillascillin	52096-50-1	342.3	C₁₈H₁₄O₇