Heishuixiecaoline A | CAS:1469493-85-3

Heishuixiecaoline A

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Description:

Heishuixiecaoline A protects against neurotoxicity in PC12 cells.

In vitro:

Molecules. 2012 Dec 18;17(12):15013-21.

Compounds from the roots and rhizomes of Valeriana amurensis protect against neurotoxicity in PC12 cells.[Pubmed: 23250029]

METHODS AND RESULTS:
Three new germacrane-type sesquiterpenoids, Heishuixiecaoline A, heishuixiecaoline B, heishuixiecaoline C (compounds 1-3), were isolated along with ten known compounds 4-13 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer's disease (AD). The structures of 1-3 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 1-13 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ(25-25)), respectively.
CONCLUSIONS:
As a result, germacrane-type sesquiterpenoids 1-4 and lignans 5-7 were seen to afford protection against Aβ-induced toxicity in PC 12 cells. This study will contribute to revealing the chemical basis for the therapeutic effect of V. amurensis against AD.

Heishuixiecaoline A Description

Source:	The herbs of Valeriana officinalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Heishuixiecaoline A
Price:
CAS No.:	1469493-85-3
Catalog No.:	CFN91090
Molecular Formula:	C₁₇H₂₄O₃
Molecular Weight:	276.37 g/mol
Purity:	>=98%
Type of Compound:	Miscellaneous
Physical Desc.:	Powder
Source:	The herbs of Valeriana officinalis
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Miscellaneous Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.6183 mL	18.0917 mL	36.1834 mL	72.3668 mL	90.4584 mL
5 mM	0.7237 mL	3.6183 mL	7.2367 mL	14.4734 mL	18.0917 mL
10 mM	0.3618 mL	1.8092 mL	3.6183 mL	7.2367 mL	9.0458 mL
50 mM	0.0724 mL	0.3618 mL	0.7237 mL	1.4473 mL	1.8092 mL
100 mM	0.0362 mL	0.1809 mL	0.3618 mL	0.7237 mL	0.9046 mL

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