Science | Nature | Cell | View More
Natural Products
Lanatoside C
Lanatoside C
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Lanatoside C
Price: $108 / 20mg
CAS No.: 17575-22-3
Catalog No.: CFN96196
Molecular Formula: C49H76O20
Molecular Weight: 985.1 g/mol
Purity: >=98%
Type of Compound: Steroids
Physical Desc.: Powder
Source: The herbs of Digitalis lanata
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / $70.2 / In-stock
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Uniwersytet Medyczny w ?odzi (Poland)
  • University of Indonesia (Indonesia)
  • University of Sao Paulo (Brazil)
  • Universita' Degli Studi Di Cagl... (Italy)
  • VIT University (India)
  • Uniwersytet Gdański (Poland)
  • Center for protein Engineering ... (Belgium)
  • Cancer Research Initatives Foun... (Malaysia)
  • Chang Gung University (Taiwan)
  • Harvard University (USA)
  • Seoul National University (Korea)
  • More...
Package
Featured Products
Limocitrin

Catalog No: CFN92385
CAS No: 489-33-8
Price: $ / mg
4-Methoxyglucobrassicin

Catalog No: CFN00505
CAS No: 83327-21-3
Price: $ / mg
Tetrahydroalstonine

Catalog No: CFN97109
CAS No: 6474-90-4
Price: $338/5mg
Oroxin A

Catalog No: CFN99712
CAS No: 57396-78-8
Price: $128/20mg
Isoliquiritin

Catalog No: CFN99155
CAS No: 5041-81-6
Price: $100/20mg
Aromadendrene

Catalog No: CFN95074
CAS No: 489-39-4
Price: $40/20mg
Pinocembrin chalcone

Catalog No: CFN96919
CAS No: 4197-97-1
Price: $/mg
Curcumin

Catalog No: CFN98686
CAS No: 458-37-7
Price: $30/20mg
Platyconic acid A

Catalog No: CFN92268
CAS No: 68051-23-0
Price: $318/5mg
Puerarin

Catalog No: CFN99169
CAS No: 3681-99-0
Price: $30/20mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Lanatoside C, a cardiac glycoside, possesses the ability to inhibit the interchange of Na and K across cell membrane and is widely used to treat anti-arrhythmias and heart failure. Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya and Sindbis virus as well as the human enterovirus 71, suggest that lanatoside C possesses broad spectrum antiviral activity against several groups of positive-sense RNA viruses.
Targets: Akt | mTOR | PKC | Antifection | Potassium Channel | Sodium Channel
In vitro:
Sci Rep. 2017 Apr 7;7:46134.
Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells.[Pubmed: 28387249 ]
Recent studies have revealed that cardiac glycosides, such as digitalis and digoxin, have anticancer activity and may serve as lead compounds for the development of cancer treatments. The poor prognosis of hepatocellular carcinoma (HCC) patients reflects the development of resistance to current chemotherapeutic agents, highlighting the need for discovering new small-molecule therapeutics.
METHODS AND RESULTS:
Here, we found that Lanatoside C, an anti-arrhythmic agent extracted from Digitalis lanata, inhibited the growth of HCC cells and dramatically decreased tumor volume as well as delayed tumor growth without obvious body weight loss. Moreover, Lanatoside C triggered mitochondrial membrane potential (MMP) loss, activation of caspases and translocation of apoptosis-inducing factor (AIF) into the nucleus, which suggests that Lanatoside C induced apoptosis through both caspase-dependent and -independent pathways. Furthermore, we discovered that Lanatoside C activated protein kinase delta (PKCδ) via Thr505 phosphorylation and subsequent membrane translocation.
CONCLUSIONS:
Inhibition of PKCδ reversed Lanatoside C-induced MMP loss and apoptosis, confirming that Lanatoside C caused apoptosis through PKCδ activation. We also found that the AKT/mTOR pathway was negatively regulated by Lanatoside C through PKCδ activation. In conclusion, we provide the first demonstration that the anticancer effects of Lanatoside C are mainly attributable to PKCδ activation.
Antiviral Res. 2014 Nov;111:93-9
Antiviral activity of lanatoside C against dengue virus infection.[Pubmed: 25251726 ]
Dengue infection poses a serious threat globally due to its recent rapid spread and rise in incidence. Currently, there is no approved vaccine or effective antiviral drug for dengue virus infection. In response to the urgent need for the development of an effective antiviral for dengue virus, the US Drug Collection library was screened in this study to identify compounds with anti-dengue activities.
METHODS AND RESULTS:
Lanatoside C, an FDA approved cardiac glycoside was identified as a candidate anti-dengue compound. Our data revealed that Lanatoside C has an IC50 of 0.19μM for dengue virus infection in HuH-7 cells. Dose-dependent reduction in dengue viral RNA and viral proteins synthesis were also observed upon treatment with increasing concentrations of Lanatoside C. Time of addition study indicated that Lanatoside C inhibits the early processes of the dengue virus replication cycle. Furthermore, Lanatoside C can effectively inhibit all four serotypes of dengue virus, flavivirus Kunjin, alphavirus Chikungunya and Sindbis virus as well as the human enterovirus 71.
CONCLUSIONS:
These findings suggest that Lanatoside C possesses broad spectrum antiviral activity against several groups of positive-sense RNA viruses.
Lanatoside C Description
Source: The herbs of Digitalis lanata
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Murracarpin

Catalog No: CFN95409
CAS No: 120786-76-7
Price: $413/5mg
erythro-Austrobailignan-6

Catalog No: CFN95501
CAS No: 114127-24-1
Price: $318/10mg
Verbasoside

Catalog No: CFN95015
CAS No: 61548-34-3
Price: $318/5mg
8-Hydroxypinoresinol diglucoside

Catalog No: CFN95083
CAS No: 112747-99-6
Price: $318/5mg
Platycogenin A

Catalog No: CFN95240
CAS No: 1459719-53-9
Price: $388/5mg
Methyl ganoderate A

Catalog No: CFN95550
CAS No: 105742-78-7
Price: $413/5mg
Isoformononetin

Catalog No: CFN95024
CAS No: 486-63-5
Price: $288/5mg
Momordicoside X

Catalog No: CFN95170
CAS No: 1333321-50-8
Price: $368/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 1.0151 mL 5.0756 mL 10.1513 mL 20.3025 mL 25.3781 mL
5 mM 0.203 mL 1.0151 mL 2.0303 mL 4.0605 mL 5.0756 mL
10 mM 0.1015 mL 0.5076 mL 1.0151 mL 2.0303 mL 2.5378 mL
50 mM 0.0203 mL 0.1015 mL 0.203 mL 0.4061 mL 0.5076 mL
100 mM 0.0102 mL 0.0508 mL 0.1015 mL 0.203 mL 0.2538 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Kinase Assay:
Neuro Oncol. 2011 Nov;13(11):1213-24.
Lanatoside C sensitizes glioblastoma cells to tumor necrosis factor-related apoptosis-inducing ligand and induces an alternative cell death pathway.[Pubmed: 21757445 ]
Human glioblastoma (GBM) cells are notorious for their resistance to apoptosis-inducing therapeutics.
METHODS AND RESULTS:
We have identified Lanatoside C as a sensitizer of GBM cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced cell death partly by upregulation of the death receptor 5. We show that Lanatoside C sensitizes GBM cells to TRAIL-induced apoptosis in a GBM xenograft model in vivo. Lanatoside C on its own serves as a therapeutic agent against GBM by activating a caspase-independent cell death pathway. Cells treated with Lanatoside C showed necrotic cell morphology with absence of caspase activation, low mitochondrial membrane potential, and early intracellular ATP depletion.
CONCLUSIONS:
In conclusion, Lanatoside C sensitizes GBM cells to TRAIL-induced cell death and mitigates apoptosis resistance of glioblastoma cells by inducing an alternative cell death pathway. To our knowledge, this is one of the first examples of use of caspase-independent cell death inducers to trigger tumor regression in vivo. Activation of such mechanism may be a useful strategy to counter resistance of cancer cells to apoptosis.
Limocitrin

Catalog No: CFN92385
CAS No: 489-33-8
Price: $ / mg
4-Methoxyglucobrassicin

Catalog No: CFN00505
CAS No: 83327-21-3
Price: $ / mg
Tetrahydroalstonine

Catalog No: CFN97109
CAS No: 6474-90-4
Price: $338/5mg
Oroxin A

Catalog No: CFN99712
CAS No: 57396-78-8
Price: $128/20mg
Isoliquiritin

Catalog No: CFN99155
CAS No: 5041-81-6
Price: $100/20mg
Aromadendrene

Catalog No: CFN95074
CAS No: 489-39-4
Price: $40/20mg
Pinocembrin chalcone

Catalog No: CFN96919
CAS No: 4197-97-1
Price: $/mg
Curcumin

Catalog No: CFN98686
CAS No: 458-37-7
Price: $30/20mg
Platyconic acid A

Catalog No: CFN92268
CAS No: 68051-23-0
Price: $318/5mg
Puerarin

Catalog No: CFN99169
CAS No: 3681-99-0
Price: $30/20mg
Tags: buy Lanatoside C | Lanatoside C supplier | purchase Lanatoside C | Lanatoside C cost | Lanatoside C manufacturer | order Lanatoside C | Lanatoside C distributor