Infigratinib (BGJ398) | CAS:872511-34-7

Infigratinib (BGJ398)

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Infigratinib (BGJ398) Description

Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Cell Research:

J Med Chem,2011 Oct 27;54(20):7066-83.

Discovery of 3-(2,6-dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), a potent and selective inhibitor of the fibroblast growth factor receptor family of receptor tyrosine kinase.[Pubmed: 21936542]

Cell lines:Murine BaF3 cell lines
Concentrations: 0 μM-0.1 μM
Incubation Time: 48 hours
Method:
Murine BaF3 cell lines, whose proliferation and survival has been rendered IL-3-independent by stable transduction with tyrosine kinases activated either by mutation or fusion with a dimerizing partner, are cultured in RPMI-1640 media supplemented with 10% FBS, 4.5 g/L glucose, 1.5 g/L sodium bicarbonate, and Pen/Strep. Cells are passaged twice weekly. BGJ398-mediated inhibition of BaF3 cell proliferation and viability is assessed using a Luciferase bioluminescent assay. Exponentially growing BaF3 or BaF3 Tel-TK cells are seeded into 384-well plates (4250 cells/well) at 50 μL/well using a μFill liquid dispenser in fresh medium. BGJ398 is serially diluted in DMSO and arrayed in a polypropylene 384-well plate. Then 50 nL of BGJ398 are transferred into the plates containing the cells by using the pintool transfer device, and the plates incubated at 37 °C (5% CO2) for 48 hours. Then 25 μL of Bright-Glo are added, and luminescence is quantified using an Analyst-GT. Custom curve-fitting software is used to produce a logistic fit of percent cell viability as a function of the logarithm of inhibitor concentration. The IC50 value is determined as the concentration of BGJ398 needed to reduce cell viability to 50% of a DMSO control.

Animal Research:

J Med Chem, 2011 Oct 27;54(20):7066-83.

Animal Models: Athymic nude-nu mice bearing parental RT112 cell line
Dosages:10 mg/kg/qd and 30 mg/kg/qd
Administration: Oral administration

Product Name	Infigratinib (BGJ398)
Price:
CAS No.:	872511-34-7
Catalog No.:	CFN60052
Molecular Formula:	C₂₆H₃₁Cl₂N₇O₃
Molecular Weight:	560.48 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

Description:	Infigratinib (BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM in cell-free assays, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes.
Targets:	FGFR1/2/3

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.7842 mL	8.9209 mL	17.8418 mL	35.6837 mL	44.6046 mL
5 mM	0.3568 mL	1.7842 mL	3.5684 mL	7.1367 mL	8.9209 mL
10 mM	0.1784 mL	0.8921 mL	1.7842 mL	3.5684 mL	4.4605 mL
50 mM	0.0357 mL	0.1784 mL	0.3568 mL	0.7137 mL	0.8921 mL
100 mM	0.0178 mL	0.0892 mL	0.1784 mL	0.3568 mL	0.446 mL

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