Isorhynchophyllic acid | CAS:144525-05-3

Isorhynchophyllic acid

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Product Name	Isorhynchophyllic acid
Price:
CAS No.:	144525-05-3
Catalog No.:	CFN98132
Molecular Formula:	C₂₁H₂₆N₂O₄
Molecular Weight:	370.44 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	White cryst.
Source:	The herbs of Uncaria rhynchophylla.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Description:

Isorhynchophyllic acid can significantly inhibit the proliferation of human cancer cells(A549, HepG2 and A2780 cells) with IC50 values being 5.8, 12.8 and 11.8 umol/L, respectively.

In vitro:

Chin. J. Nat. Med.,2016 Mar;14(3):232-5.

Two new ortho benzoquinones from Uncaria rhynchophylla.[Pubmed: 27025371]

The present study was designed to determine the chemical constituents of the stems and hooks of Uncaria rhynchophylla.
METHODS AND RESULTS:
The chemical constituents were isolated and purified from CH2Cl2 fraction by chromatography. Their structures were elucidated by spectroscopic analyses. Their cytotoxicity was tested using MTT method. Two new ortho benzoquinones, 3-diethylamino-5-methoxy-1, 2-benzoquinone (1) and 3-ethylamino-5-methoxy-1, 2-benzoquinone (2), together with a known compound Isorhynchophyllic acid (3) were isolated from U. rhynchophylla. These compounds were evaluated for their cytotoxicity against cancer cells A549, HepG2 and A2780.
CONCLUSIONS:
Compounds 1 and 2 were new ortho benzoquinones and showed weak antiproliferative activities on A549, HepG2 and A2780 cells. Compound 3 significantly inhibited the proliferation of A549, HepG2 and A2780 cells with IC50 values being 5.8, 12.8 and 11.8 μmol·L(-1), respectively.

Isorhynchophyllic acid Description

Source:	The herbs of Uncaria rhynchophylla.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-proliferation Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.6995 mL	13.4975 mL	26.9949 mL	53.9898 mL	67.4873 mL
5 mM	0.5399 mL	2.6995 mL	5.399 mL	10.798 mL	13.4975 mL
10 mM	0.2699 mL	1.3497 mL	2.6995 mL	5.399 mL	6.7487 mL
50 mM	0.054 mL	0.2699 mL	0.5399 mL	1.0798 mL	1.3497 mL
100 mM	0.027 mL	0.135 mL	0.2699 mL	0.5399 mL	0.6749 mL

CFN98132	Isorhynchophyllic acid	144525-05-3	370.44	C₂₁H₂₆N₂O₄
CFN90218	Corynoxine	6877-32-3	384.47	C₂₂H₂₈N₂O₄
CFN92553	Isorhyncophylline	6859-01-4	384.5	C₂₂H₂₈N₂O₄
CFN98131	Rhynchophylline	76-66-4	384.47	C₂₂H₂₈N₂O₄
CFN98154	Corynoxeine	630-94-4	382.45	C₂₂H₂₆N₂O₄
CFN98155	Isocorynoxeine	51014-29-0	382.45	C₂₂H₂₆N₂O₄
CFN92844	Dihydrocorynantheine	4684-43-9	368.5	C₂₂H₂₈N₂O₃