Jolkinol A | CAS:62820-11-5 | Manufacturer ChemFaces

Jolkinol A

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Description:

Jolkinol A can inhibit both MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) cell lines, with GI50 values ranging between 40.9 microM and 95.3 microM.

In vitro:

Planta Med. 2004 Mar;70(3):244-9.

Euphopubescenol and euphopubescene, two new jatrophane polyesters, and lathyrane-type diterpenes from Euphorbia pubescens.[Pubmed: 15114502]

METHODS AND RESULTS:
Two known lathyrane derivatives, Jolkinol A ( 3) and Jolkinol A ( 4), whose (13)C-NMR spectra were assigned, were also isolated. Compounds 1 - 3 have been evaluated for their ability to inhibit the in vitro growth of three human tumour cell lines representing different tumour types, MCF-7 (breast adenocarcinoma), NCI-H460 (non-small cell lung cancer) and SF-268 (CNS cancer).
CONCLUSIONS:
They inhibited both MCF-7 and NCI-H460 cell lines, with GI50 values ranging between 40.9 microM and 95.3 microM, but were found to be ineffective as growth inhibitors of the SF-268 cell line

Jolkinol A Description

Source:	The seeds of Euphorbia lathyris L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Jolkinol A
Price:
CAS No.:	62820-11-5
Catalog No.:	CFN92878
Molecular Formula:	C₂₉H₃₆O₆
Molecular Weight:	480.6 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The seeds of Euphorbia lathyris L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.0807 mL	10.4037 mL	20.8073 mL	41.6146 mL	52.0183 mL
5 mM	0.4161 mL	2.0807 mL	4.1615 mL	8.3229 mL	10.4037 mL
10 mM	0.2081 mL	1.0404 mL	2.0807 mL	4.1615 mL	5.2018 mL
50 mM	0.0416 mL	0.2081 mL	0.4161 mL	0.8323 mL	1.0404 mL
100 mM	0.0208 mL	0.104 mL	0.2081 mL	0.4161 mL	0.5202 mL

CFN91052	Euphorbia factor L7b	93550-95-9	580.67	C₃₃H₄₀O₉
CFN95334	Euphorbia factor L24	1613700-13-2	538.6	C₃₁H₃₈O₈
CFN92878	Jolkinol A	62820-11-5	480.6	C₂₉H₃₆O₆
CFN98559	Epoxylathyrol	28649-60-7	350.45	C₂₀H₃₀O₅
CFN95339	Euphorbia factor L25	303174-98-3	538.6	C₃₁H₃₈O₈
CFN92883	Euphorbia factor L1	76376-43-7	552.7	C₃₂H₄₀O₈
CFN95340	Deoxy euphorbia factor L1	247099-01-0	536.7	C₃₂H₄₀O₇
CFN95342	New compound 9	N/A	538.6	C₃₁H₃₈O₈
CFN92488	7-beta-Hydroxylathyrol	34208-98-5	350.5	C₂₀H₃₀O₅
CFN99706	Euphorbia factor L3	218916-52-0	522.63	C₃₁H₃₈O₇