Kaji-ichigoside F1 | CAS:95298-47-8 | Manufacturer ChemFaces

Kaji-ichigoside F1

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Kaji-ichigoside F1 shows antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats. Kaji-ichigoside F1 exhibits in vivo hepatoprotective effects, it inhibited d-GalN-induced cytotoxicity in primary cultured mouse hepatocytes with the IC50 of14.1uM.

Targets:

Immunology & Inflammation related

In vitro:

Phytochemistry. 2014 Jun;102:169-81.

Hepatoprotective triterpenes from traditional Tibetan medicine Potentilla anserina.[Pubmed: 24697904 ]

METHODS AND RESULTS:
A methanol extract from the tuberous roots of Potentilla anserina (Rosaceae) exhibited hepatoprotective effects against d-galactosamine (d-GalN)/lipopolysaccharide-induced liver injuries in mice. Six triterpene 28-O-monoglucopyranosyl esters, potentillanosides A-F, were isolated from the extract along with 32 known compounds, including 15 triterpenes. The structures of potentillanosides A-F were determined on the basis of spectroscopic properties and chemical evidence. Four ursane-type triterpene 28-O-monoglycosyl esters, potentillanoside A (IC50=46.7μM), 28-O-β-d-glucopyranosyl pomolic acid (IC50=9.5μM), rosamutin (IC50=35.5μM), and Kaji-ichigoside F1 (IC50=14.1μM), inhibited d-GalN-induced cytotoxicity in primary cultured mouse hepatocytes.
CONCLUSIONS:
Among these four triterpenes, potentillanoside A, rosamutin, and Kaji-ichigoside F1 exhibited in vivo hepatoprotective effects at doses of 50-100mg/kg, p.o. The mode of action was ascribable to the reduction in cytotoxicity caused by d-GalN.

Kaji-ichigoside F1 Description

Source:	The tuberous roots of Potentilla anserina.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Biol Pharm Bull. 2005 Jan;28(1):101-4.

19Alpha-hydroxyursane-type triterpenoids: antinociceptive anti-inflammatory principles of the roots of Rosa rugosa.[Pubmed: 15635171]

To search for antiinflammtory 19alpha-hydroxyursane-type triterpenoids, the MeOH extract of the roots of Rosa rugosa (Rosaceae) was fractionated.
METHODS AND RESULTS:
The active fraction of the EtOAc extract was hydrolyzed in alkaline solution to give a hydrolyzed fraction. Both extracts showed antiinflammatory/antinociceptive action in acetic acid-induced writhing and hot plate testing and in a carrageenan-induced paw edema model in mice and rats. Repeated chromatography of the EtOAc extract on both silica gel and octadecylsilane columns led to the isolation of Kaji-ichigoside F1 (1, euscaphic acid 28-O-glucoside) and rosamultin (2, tormentic acid 28-O-glucoside). The hydrolyzed fraction was also subjected to silica gel column and octadecylsilane column chromatography to produce euscaphic acid (3) and tormentic acid (4). The potencies were observed in the following order: 4>3>2>1.
CONCLUSIONS:
These results suggest that 19alpha-hydroxyursane-type triterpenoids are responsible for the antiinflammatory/antinociceptive action of R. rugosa roots.

Product Name	Kaji-ichigoside F1
Price:
CAS No.:	95298-47-8
Catalog No.:	CFN89311
Molecular Formula:	C₃₆H₅₈O₁₀
Molecular Weight:	650.85 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The tuberous roots of Potentilla anserina.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-inflammatory Compound Library Hepatoprotective Compound Library Anti-nociceptive Compound Library Triterpenoids Compound Library Immunology & Inflammation related Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.5365 mL	7.6823 mL	15.3645 mL	30.729 mL	38.4113 mL
5 mM	0.3073 mL	1.5365 mL	3.0729 mL	6.1458 mL	7.6823 mL
10 mM	0.1536 mL	0.7682 mL	1.5365 mL	3.0729 mL	3.8411 mL
50 mM	0.0307 mL	0.1536 mL	0.3073 mL	0.6146 mL	0.7682 mL
100 mM	0.0154 mL	0.0768 mL	0.1536 mL	0.3073 mL	0.3841 mL

CFN98464	Ziyuglycoside I	35286-58-9	767.0	C₄₁H₆₆O₁₃
CFN92574	3-Oxopomolic acid	13849-90-6	470.7	C₃₀H₄₆O₄
CFN92820	3-Oxopomolic acid methyl ester	14440-23-4	484.7	C₃₁H₄₈O₄
CFN99349	Uncaric acid	123135-05-7	488.7	C₃₀H₄₈O₅
CFN99892	6,19-Dihydroxyurs-12-en-3-oxo-28-oic acid	194027-11-7	486.7	C₃₀H₄₆O₅
CFN95459	3beta-(alpha-L-Arabinopyranosyloxy)urs-12,18-dien-28-oic acid beta-D-glucopyranosyl ester	435269-07-1	749.0	C₄₁H₆₄O₁₂
CFN95460	Oblonganoside D	943021-91-8	749.0	C₄₁H₆₄O₁₂
CFN91575	Oblonganoside B	943021-89-4	749.0	C₄₁H₆₄O₁₂
CFN95461	3beta-Hydroxyurs-12,18-dien-28-oic acid beta-D-glucopyranosyl ester	434942-42-4	616.8	C₃₆H₅₆O₈
CFN98465	Ziyuglycoside II	35286-59-0	604.8	C₃₅H₅₆O₈