Kawain | CAS:500-64-1 | Manufacturer ChemFaces

Kawain

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Size /Price /Stock	10 mM * 1 mL in DMSO / $17.7 / In-stock
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Description:

Kavain has anticonvulsive properties, attenuating vascular smooth muscle contraction through interactions with voltage-dependent Na+ and Ca2+ channels. Kawain is advanced glycation endproduct inhibitors, can increase the mean life span of Caenorhabditis elegans exposed to high glucose.

Targets:

NMDAR

In vitro:

Prog Neuropsychopharmacol Biol Psychiatry. 1997 May;21(4):697-706.

Effects of kawain and dihydromethysticin on field potential changes in the hippocampus.[Pubmed: 9194150]

1. The kava-pyrones Kawain and dihydromethysticin are constituents of Piper methysticum which exert anticonvulsant, analgesic and anxiolytic properties.
METHODS AND RESULTS:
3. Kawain and dihydromethysticin reduced reversibly the frequency of occurrence of fp in a concentration range from 5 to 40 mumol/l and 10 to 40 mumol/l, respectively. 4. Reduction of the fp frequency after addition of subthreshold concentrations of 5 mumol/l Kawain and 10 mumol/l dihydromethysticin indicated additive actions of both drugs. 5. Since the serotonin-1A agonist ipsapirone also exerts anxiolytic effects, subthreshold concentrations of Kawain or dihydromethysticin were combined with a subthreshold concentration of ipsapirone in another set of experiments. Combining Kawain and ipsapirone or dihydromethysticin and ipsapirone caused a reduction of the rate of fp to 0.76 and 0.81 of the baseline value, respectively.
CONCLUSIONS:
6. The findings suggest that (i) single constituents of Piper methysticum may have additive actions, (ii) that the two components Kawain and dihydromethysticin may enhance the effects of the anxiolytic serotonin-1A agonist ipsapirone and (iii) that activation of NMDA receptors and/or voltage dependent calcium channels may be involved in the elementary mechanism of action of some kava-pyrones.

In vivo:

Drug Metab Dispos. 2005 Oct;33(10):1555-63.

Pharmacokinetics and disposition of the kavalactone kawain: interaction with kava extract and kavalactones in vivo and in vitro.[Pubmed: 16033948]

METHODS AND RESULTS:
The oral pharmacokinetics of the kavalactone, Kawain (100 mg/kg), were determined in rats with and without coadministration of kava extract (256 mg/kg) to study the effect of the extract on drug disposition. Kawain was well absorbed, with >90% of the dose eliminated within 72 h, chiefly in urine. Compared with Kawain alone, coadministration with kava extract caused a tripling of Kawain AUC(0-8 h) and a doubling of C(max). However, a 7-day pretreatment with kava extract (256 mg /kg/day) had no effect on the pharmacokinetics of Kawain administered on day 8.
CONCLUSIONS:
The 7-day pretreatment with kava extract only modestly induced hepatic P450 activities.

Kawain Description

Source:	The roots of Piper methysticum Forst
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Planta Med. 2014 Aug;80(12):1001-8.

Kavalactones, a novel class of protein glycation and lipid peroxidation inhibitors.[Pubmed: 25098935]

Kawain, methysticin, and dihydromethysticin, all belonging to the group of kavalactones, were identified as advanced glycation endproduct inhibitors.
METHODS AND RESULTS:
With IC50 values of 43.5 ± 1.2 μM and 45.0 ± 1.3 μM for Kawain and methysticin, respectively, the compounds inhibited the in vitro protein glycation significantly better than aminoguanidine (IC50 = 231.0 ± 11.5 μM; p = 0.01), an established reference compound. Kawain and methysticin also inhibited the formation of dicarbonyl compounds, which are intermediates in the process of advanced glycation endproduct formation.
CONCLUSIONS:
Similarly, Kawain and aminoguanidine prevented the formation of thiobarbituric reactive substances in both low-density lipoprotein and linoleic acid oxidation. Moreover, Kawain and aminoguanidine prevented advanced glycation endproduct formation by chelating Fe(3+) and Cu(2+) two to three times better than aminoguanidine. Furthermore, Kawain increased the mean life span of Caenorhabditis elegans exposed to high glucose.

Product Name	Kawain
Price:	$80 / 20mg
CAS No.:	500-64-1
Catalog No.:	CFN92656
Molecular Formula:	C₁₄H₁₄O₃
Molecular Weight:	230.3 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The roots of Piper methysticum Forst
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Anti-aging Compound Library Anxiolytic Compound Library Phenols Compound Library NMDAR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.3422 mL	21.7108 mL	43.4216 mL	86.8432 mL	108.5541 mL
5 mM	0.8684 mL	4.3422 mL	8.6843 mL	17.3686 mL	21.7108 mL
10 mM	0.4342 mL	2.1711 mL	4.3422 mL	8.6843 mL	10.8554 mL
50 mM	0.0868 mL	0.4342 mL	0.8684 mL	1.7369 mL	2.1711 mL
100 mM	0.0434 mL	0.2171 mL	0.4342 mL	0.8684 mL	1.0855 mL

CFN91561	4-Methyl-6-(3',4'-dihydroxystyryl)-2-pyrone	149947-22-8	260.2	C₁₄H₁₂O₅
CFN90160	Methysticin	20697-20-5	274.27	C₁₅H₁₄O₅
CFN90332	Dihydromethysticin	19902-91-1	276.28	C₁₅H₁₆O₅
CFN97803	Goniothalamin	17303-67-2	200.23	C₁₃H₁₂O₂
CFN92656	Kawain	500-64-1	230.3	C₁₄H₁₄O₃
CFN90149	Desmethoxy yangonin	15345-89-8	228.24	C₁₄H₁₂O₃
CFN92690	p-Hydroxy-5,6-dehydrokawain	39986-86-2	244.2	C₁₄H₁₂O₄
CFN92658	Yangonin	500-62-9	258.3	C₁₅H₁₄O₄
CFN92659	5,6-Dihydroyangonin	3328-60-7	260.3	C₁₅H₁₆O₄
CFN92660	Hispidin	56070-89-4	288.3	C₁₆H₁₆O₅