| Structure Identification: |
| Masters thesis,2009, University of Malaya. | | Alkaloids isolated from litsea petiolata and phoebe tavoyana (Lauraceae).[Reference: WebLink] | A study on the alkaloidal composition of two Malaysian plants from the family of Lauraceae i.e Litsea petiolata Hk.F and Phoebe tavoyana (Meissn.) Hk.F., has been carried out.
METHODS AND RESULTS:
The alkaloids were extracted with dichloromethane, whereas the isolation of the alkaloids was achieved by various chromatographic techniques such as column chromatography and preparative thin layer chromatography. A total of 14 compounds were isolated of which two are new alkaloids. The structural elucidations were carried out via spectroscopic methods; notably 1D and 2D NMR (COSY, HMQC, HMBC, NOE-DIFF), MS, IR, UV and comparison with the published data. Investigation of the alkaloidal content from the bark of Litsea petiolata afforded five alkaloids. Compounds isolated are two indole alkaloids (Î2-carboline) namely Harman or aribine 52, norharman 53, along with the three known isoquinoline alkaloids which normally occur in Lauraceae plant; Benzylisoquinolines: reticuline 31, aporphine: isoboldine 61; and one simple isoquinoline: thalifoline 100. Î2-carboline alkaloid: Harman and norharman type were isolated for the first time in the genus of Litsea.
CONCLUSIONS:
Isolation and purification of alkaloids from the bark of Phoebe tavoyana afforded 9 alkaloids of which 2 are new compounds: (+)-tavoyanine 101 and (-)-tavoyanine 102 along with four known aporphines; norboldine 77, Laetanine 73, roemerine 84, boldine 74 and one morphinandienone, sebiferine 103. |
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