Lasiodin | CAS:28957-08-6 | Manufacturer ChemFaces

Lasiodin

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Lasiodin Description

Source:	The herbs of Isodon japonicus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

PLoS One. 2014 May 20;9(5):e97799.

Lasiodin inhibits proliferation of human nasopharyngeal carcinoma cells by simultaneous modulation of the Apaf-1/caspase, AKT/MAPK and COX-2/NF-κB signaling pathways.[Pubmed: 24845412]

Rabdosia serra has been widely used for the treatment of the various human diseases. However, the antiproliferative effects and underlying mechanisms of the compounds in this herb remain largely unknown.
METHODS AND RESULTS:
In this study, an antiproliferative compound against human nasopharyngeal carcinoma (NPC) cells from Rabdosia serra was purified and identified as Lasiodin (a diterpenoid). The treatment with Lasiodin inhibited cell viability and migration. Lasiodin also mediated the cell morphology change and induced apoptosis in NPC cells. The treatment with Lasiodin induced the Apaf-1 expression, triggered the cytochrome-C release, and stimulated the PARP, caspase-3 and caspase-9 cleavages, thereby activating the apoptotic pathways. The treatment with Lasiodin also significantly inhibited the phosphorylations of the AKT, ERK1/2, p38 and JNK proteins. The pretreatment with the AKT or MAPK-selective inhibitors considerably blocked the Lasiodin-mediated inhibition of cell proliferation. Moreover, the treatment with Lasiodin inhibited the COX-2 expression, abrogated NF-κB binding to the COX-2 promoter, and promoted the NF-κB translocation from cell nuclei to cytosol. The pretreatment with a COX-2-selective inhibitor abrogated the Lasiodin-induced inhibition of cell proliferation.
CONCLUSIONS:
These results indicated that Lasiodin simultaneously activated the Apaf-1/caspase-dependent apoptotic pathways and suppressed the AKT/MAPK and COX-2/NF-κB signaling pathways. This study also suggested that Lasiodin could be a promising natural compound for the prevention and treatment of NPC.

Product Name	Lasiodin
Price:
CAS No.:	28957-08-6
Catalog No.:	CFN92430
Molecular Formula:	C₂₂H₃₀O₇
Molecular Weight:	406.5 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Cryst.
Source:	The herbs of Isodon japonicus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Antibacterial Compound Library Diterpenoids Compound Library PARP Inhibitor Library P450 (e.g. CYP17) Inhibitor Library p38MAPK Inhibitor Library NF-kB Inhibitor Library JNK Inhibitor Library ERK Inhibitor Library COX Inhibitor Library Caspase Inhibitor Library Akt Inhibitor Library

Description:	Lasiokaurin has anti-oxidative, and antineoplastic activities, it also shows antibacterial activity, esp. against Sarcina lutea.
Targets:	P450 (e.g. CYP17) \| PARP \| Caspase \| Akt \| ERK \| JNK \| p38MAPK \| COX \| NF-kB

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.46 mL	12.3001 mL	24.6002 mL	49.2005 mL	61.5006 mL
5 mM	0.492 mL	2.46 mL	4.92 mL	9.8401 mL	12.3001 mL
10 mM	0.246 mL	1.23 mL	2.46 mL	4.92 mL	6.1501 mL
50 mM	0.0492 mL	0.246 mL	0.492 mL	0.984 mL	1.23 mL
100 mM	0.0246 mL	0.123 mL	0.246 mL	0.492 mL	0.615 mL

CFN99164	Oridonin	28957-04-2	364.43	C₂₀H₂₈O₆
CFN98377	Effusanin A	30220-43-0	348.4	C₂₀H₂₈O₅
CFN92434	Effusanin B	76470-16-1	390.5	C₂₂H₃₀O₆
CFN92430	Lasiodin	28957-08-6	406.5	C₂₂H₃₀O₇
CFN97266	Longikaurin E	77949-42-9	390.5	C₂₂H₃₀O₆
CFN92262	Effusanin E	76470-15-0	364.4	C₂₀H₂₈O₆
CFN92314	Taibaihenryiins A	398129-59-4	406.5	C₂₂H₃₀O₇
CFN92311	Shikokianin	24267-69-4	448.5	C₂₄H₃₂O₈
CFN98386	Xerophilusin G	304642-94-2	422.5	C₂₂H₃₀O₈
CFN97984	Trichokaurin	23811-50-9	434.5	C₂₄H₃₄O₇