Limonol | CAS:989-61-7 | Manufacturer ChemFaces

Limonol

ChemFaces products have been cited in many studies from excellent and top scientific journals

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Limonol-derivatives could as promising scaffolds for the design of novel Hsp90α inhibitors.

Targets:

Raf | ATPase | Akt | HSP (e.g. HSP90)

In vitro:

Fitoterapia. 2000 Jun;71(3):317-20.

Antifungal activity of some tetranortriterpenoids.[Pubmed: 10844171]

METHODS AND RESULTS:
Natural tetranortriterpenoids such as cedrelone from Toona ciliata, azadiradione from Azadirachta indica, limonin, Limonol and nomilinic acid from Citrus medica, along with some cedrelone derivatives were tested for their antifungal activity against Puccinia arachidis, a groundnut rust pathogen. Results show that cedrelone was the most effective in reducing rust pustule emergence.
CONCLUSIONS:
Replacement of functional groups or modification of the A or the B ring in cedrelone reduced the effectiveness indicating the importance of specific structural features for activity.

Chemistry. 2016 Sep 5;22(37):13236-50.

Identification of Limonol Derivatives as Heat Shock Protein 90 (Hsp90) Inhibitors through a Multidisciplinary Approach.[Pubmed: 27492719 ]

The identification of inhibitors of Hsp90 is currently a primary goal in the development of more effective drugs for the treatment of various types of multidrug resistant malignancies.
METHODS AND RESULTS:
In an attempt to identify new small molecules modulating the activity of Hsp90, we screened a small library of tetranortriterpenes. A high-affinity interaction with Hsp90 inducible form was uncovered for eight of these compounds, five of which are described here for the first time. By monitoring the ATPase activity and the citrate synthase thermal induced aggregation, compound 1 (cedrelosin A), 3 (7α-limonylacetate), and 5 (cedrelosin B), containing a Limonol moiety, were found to be the most effective in compromising the Hsp90α chaperone activity. Consistent with these findings, the three compounds caused a depletion of c-Raf and pAkt Hsp90 client proteins in HeLa and MCF/7 cell lines. Induced fit docking protocol and molecular dynamics were used to rationalize the structural basis of the biological activity of the Limonol derivatives.
CONCLUSIONS:
Taken together, these results point to Limonol-derivatives as promising scaffolds for the design of novel Hsp90α inhibitors.

Limonol Description

Source:	The barks of Melia azedarach L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Limonol
Price:
CAS No.:	989-61-7
Catalog No.:	CFN97564
Molecular Formula:	C₂₆H₃₂O₈
Molecular Weight:	472.5 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The barks of Melia azedarach L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Triterpenoids Compound Library RAF Inhibitor Library HSP (e.g. HSP90) Inhibitor Library ATPase Inhibitor Library Akt Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1164 mL	10.582 mL	21.164 mL	42.328 mL	52.9101 mL
5 mM	0.4233 mL	2.1164 mL	4.2328 mL	8.4656 mL	10.582 mL
10 mM	0.2116 mL	1.0582 mL	2.1164 mL	4.2328 mL	5.291 mL
50 mM	0.0423 mL	0.2116 mL	0.4233 mL	0.8466 mL	1.0582 mL
100 mM	0.0212 mL	0.1058 mL	0.2116 mL	0.4233 mL	0.5291 mL

CFN97565	Limonexic acid	99026-99-0	502.5	C₂₆H₃₀O₁₀
CFN96839	Isolimonexic acid	73904-93-5	502.51	C₂₆H₃₀O₁₀
CFN97564	Limonol	989-61-7	472.5	C₂₆H₃₂O₈
CFN99280	Limonin	1180-71-8	470.5	C₂₆H₃₀O₈
CFN91424	Desoxylimonin	989-23-1	454.5	C₂₆H₃₀O₇
CFN99256	Glaucin B	115458-73-6	528.6	C₂₈H₃₂O₁₀
CFN96685	Rutaevin	33237-37-5	486.51	C₂₆H₃₀O₉
CFN91983	Rutaevin 7-acetate	62306-81-4	528.55	C₂₈H₃₂O₁₀
CFN98214	Evodol	22318-10-1	484.5	C₂₆H₂₈O₉
CFN99328	12alpha-Hydroxyevodol	120722-04-5	500.5	C₂₆H₂₈O₁₀