Linderene | CAS:26146-27-0 | Manufacturer ChemFaces

Linderene

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $71.9 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Linderene Description

Source:	The roots of Lindera aggregata( Sims) Kosterm
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Biol Pharm Bull. 2002 Aug;25(8):1049-52.

Prolyl endopeptidase inhibitors from the roots of Lindera strychnifolia F. Vill.[Pubmed: 12186408]

We studied the PEP inhibitory constituents of the roots of Lindera strychnifolia F. VILL and isolated two known tannins, epicatechin (1) and aesculitannin B (2), and four known sesquiterpenes, Linderene (3), Linderene acetate (4), linderalactone (5) and isolinderalactone (6) as inhibitors.
METHODS AND RESULTS:
On the inhibitory activities of six compounds against PEP from Flavobacterium meningosepticum and that from rat brain supernatant, compounds 1, 2 and Linderene acetate inhibited the enzyme from Flavobacterium more strongly than that from rat brain supernatant. However, Linderene, linderalactone and isolinderalactone inhibited the enzymes from both origins to the same extent and furthermore, compound 6 was the strongest natural inhibitor against PEP from rat brain supernatant.
CONCLUSIONS:
The kinetic study of these inhibitors indicated that compounds 1, 2 are noncompetitive inhibitors and compounds Linderene,linderalactone,isolinderalactone are competitive inhibitors.

Product Name	Linderene
Price:	$218 / 10mg
CAS No.:	26146-27-0
Catalog No.:	CFN90639
Molecular Formula:	C₁₅H₁₈O₂
Molecular Weight:	230.3 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The roots of Lindera aggregata( Sims) Kosterm
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Inhibitors Compound Library Sesquiterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.3422 mL	21.7108 mL	43.4216 mL	86.8432 mL	108.5541 mL
5 mM	0.8684 mL	4.3422 mL	8.6843 mL	17.3686 mL	21.7108 mL
10 mM	0.4342 mL	2.1711 mL	4.3422 mL	8.6843 mL	10.8554 mL
50 mM	0.0868 mL	0.4342 mL	0.8684 mL	1.7369 mL	2.1711 mL
100 mM	0.0434 mL	0.2171 mL	0.4342 mL	0.8684 mL	1.0855 mL

CFN92027	Curzerenone	20493-56-5	230.3	C₁₅H₁₈O₂
CFN92613	Epicurzerenone	20085-85-2	230.3	C₁₅H₁₈O₂
CFN99762	Isolinderalactone	957-66-4	244.29	C₁₅H₁₆O₃
CFN92066	Atractylone	6989-21-5	216.3	C₁₅H₂₀O
CFN90639	Linderene	26146-27-0	230.3	C₁₅H₁₈O₂
CFN91930	Linderene acetate	26146-28-1	272.34	C₁₇H₂₀O₃
CFN91933	Strychnistenolide	332372-09-5	262.30	C₁₅H₁₈O₄
CFN95794	Strychnistenolide 6-O-acetate	325969-56-0	304.3	C₁₇H₂₀O₅
CFN91948	8beta,9alpha-Dihydroxylindan-4(5),7(11)-dien-8alpha,12-olide	956707-04-3	262.30	C₁₅H₁₈O₄
CFN92651	Curcolone	17015-43-9	246.3	C₁₅H₁₈O₃