Lupinalbin A | CAS:98094-87-2 | Manufacturer ChemFaces

Lupinalbin A

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Description:

Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae). It exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokines and blocking of IFN-β/STAT1 pathway activation.

Targets:

STAT | IFN-γ | IL Receptor | Estrogen receptor | Progestogen receptor

In vitro:

Molecules. 2018 Mar 6;23(3). pii: E583.

Anti-Inflammatory Effect of Lupinalbin A Isolated from Apios americana on Lipopolysaccharide-Treated RAW264.7 Cells.[Pubmed: 29509670 ]

Apios americana, a leguminous plant, is used as food in some countries. Although the biological activities of Apios extract have been reported, there have been no reports about the anti-inflammatory mechanism of Lupinalbin A on the RAW264.7 cells.
METHODS AND RESULTS:
In this study, we investigated the anti-inflammatory effect of A. americana Lupinalbin A on lipopolysaccharide (LPS)-treated RAW264.7 cells. Lupinalbin A significantly inhibited nitric oxide production and inducible nitric oxide synthase expression in LPS-treated RAW264.7 cells. The expression of cytokines, including interleukin-6, tumor necrosis factor-α, and chemokine of monocyte chemoattractant protein, was reduced under Lupinalbin A exposure in LPS-treated RAW264.7 cells. In addition, Lupinalbin A significantly decreased LPS-induced interferon (IFN)-β production and STAT1 protein levels in RAW264.7 cells.
CONCLUSIONS:
Taken together, these results suggest that A. americana Lupinalbin A exerts anti-inflammatory effects via the inhibition of pro-inflammatory cytokines and blocking of IFN-β/STAT1 pathway activation.

Lupinalbin A Description

Source:	The herbs of Lupinus albus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

BMC Complement Altern Med. 2014 Aug 9;14:294.

Lupinalbin A as the most potent estrogen receptor α- and aryl hydrocarbon receptor agonist in Eriosema laurentii de Wild. (Leguminosae).[Pubmed: 25106881 ]

Eriosema laurentii De Wild. (Leguminosae) is a plant used in Cameroon against infertility and gynecological or menopausal complaints. In our previous report, a methanol extract of its aerial parts was shown to exhibit estrogenic and aryl hydrocarbon receptor agonistic activities in vitro and to prevent menopausal symptoms in ovariectomized Wistar rats.
METHODS AND RESULTS:
In order to determine the major estrogen receptor α (ERα) agonists in the extract, an activity-guided fractionation was performed using the ERα yeast screen. To check whether the ERα active fractions/compounds also accounted for the aryl hydrocarbon receptor (AhR) agonistic activity of the crude methanol extract, they were further tested on the AhR yeast screen. This study led to the identification of 2'-hydroxygenistein, Lupinalbin A and genistein as major estrogenic principles of the extract. 2'-hydroxygenistein and Lupinalbin A were, for the first time, also shown to possess an AhR agonistic activity, whereas genistein was not active in this assay. In addition, it was possible to deduce structure-activity relationships.
CONCLUSIONS:
These results suggest that the identified compounds are the major active principles responsible for the estrogenic and AhR agonistic activities of the crude methanol extract of the aerial parts of Eriosema laurentii.

Product Name	Lupinalbin A
Price:
CAS No.:	98094-87-2
Catalog No.:	CFN80045
Molecular Formula:	C₁₅H₈O₆
Molecular Weight:	284.03 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The herbs of Lupinus albus
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Flavonoids Compound Library STAT Inhibitor Library Progestogen receptor Inhibitor Library IL Receptor Inhibitor Library IFN-γ Inhibitor Library Estrogen receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.5208 mL	17.6038 mL	35.2075 mL	70.4151 mL	88.0189 mL
5 mM	0.7042 mL	3.5208 mL	7.0415 mL	14.083 mL	17.6038 mL
10 mM	0.3521 mL	1.7604 mL	3.5208 mL	7.0415 mL	8.8019 mL
50 mM	0.0704 mL	0.3521 mL	0.7042 mL	1.4083 mL	1.7604 mL
100 mM	0.0352 mL	0.176 mL	0.3521 mL	0.7042 mL	0.8802 mL

CFN97931	Dalbergioidin	30368-42-4	288.3	C₁₅H₁₂O₆
CFN99257	2'-Hydroxygenistein	1156-78-1	286.2	C₁₅H₁₀O₆
CFN80045	Lupinalbin A	98094-87-2	284.03	C₁₅H₈O₆
CFN97861	Barpisoflavone A	101691-27-4	300.27	C₁₆H₁₂O₆
CFN98419	Cajanin	32884-36-9	300.3	C₁₆H₁₂O₆
CFN97891	Homoferreirin	482-01-9	316.3	C₁₇H₁₆O₆
CFN96513	Sophoraisoflavone A	117204-81-6	352.34	C₂₀H₁₆O₆
CFN96544	Licoisoflavanone	66067-26-3	354.36	C₂₀H₁₈O₆
CFN94013	Glyasperin F	145382-61-2	354.35	C₂₀H₁₈O₆
CFN95073	Dihydrolicoisoflavone	164163-92-2	356.4	C₂₀H₂₀O₆