Medicarpin 3-O-glucoside | CAS:52766-70-8

Medicarpin 3-O-glucoside

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Description:

Medicarpin-3-O-glucoside, a phytoalexin, shows inhibition against the germination of G. intraradices spores and hyphal elongation.

In vitro:

Plant Sci. 2001 Apr;160(5):925-932.

The defense response elicited by the pathogen Rhizoctonia solani is suppressed by colonization of the AM-fungus Glomus intraradices.[Pubmed: 11297789]

METHODS AND RESULTS:
Defense responses of alfalfa roots to the pathogenic fungus Rhizoctonia solani were reduced significantly in roots simultaneously infected with the vesicular arbuscular mycorrhizal (AM) fungus Glomus intraradices. R. solani induced five- to tenfold increases in the steady-state levels of chalcone isomerase and isoflavone reductase mRNAs a doubling of root peroxidase activity and a marked autofluorescence in the infected tissue. These changes were inhibited by the presence of G. intraradices. Interestingly, germination of G. intraradices spores and hyphal elongation were sensitive to low concentrations (2 µM) of Medicarpin 3-O-glucoside, an isoflavonoid phytoalexin that accumulated both in roots colonized by the pathogenic fungus as well as in AM-treated roots receiving high P, where no colonization by the beneficial fungus occurred.
CONCLUSIONS:
These data support the hypothesis that during early stages of colonization by G. intraradices, suppression of defense-related properties is associated with the successful establishment of AM symbiosis.

Medicarpin 3-O-glucoside Description

Source:	The roots of Ononis spinosa L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

J Ethnopharmacol. 2018 Jan 30;211:384-393.

Isoflavonoids as wound healing agents from Ononidis Radix.[Pubmed: 28989011 ]

Dried roots of Ononis spinosa L. are traditionally used for their diuretic, anti-inflammatory and wound healing effects. Isolation of the bioactive compounds of Ononis spinosa L. subsp. leiosperma (Boiss.) Sirj.
METHODS AND RESULTS:
Ethyl acetate extract prepared from the roots of Ononis spinosa L. subsp. leiosperma (Boiss.) Sirj. was subjected to silica gel column. The fractions were tested for their wound healing and anti-inflammatory activities. Linear incision and circular excision wound models and hydroxypyroline estimation assay were used for the wound healing activity. Carrageenan-induced hind paw edema, TPA-induced ear edema and acetic acid-induced increase in capillary permeability tests as acute inflammation; FCA-induced arthritis as chronic inflammation models were used for the assessment of anti-inflammatory activity. Antioxidant capacities of the fractions were tested using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, 2,2-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid (ABTS) scavenging activity assay, reducing power assay and hydroxyl radical (OH-) scavenging assay. The isolation procedure was continued with the active fraction (Fr-E5). Fr-E5 exhibited remarkable wound healing activity with the 33.4% tensile strength value on the linear incision wound model and 51.4% reduction of the wound area at the day 12 on the circular excision wound model. Hydroxyproline content of the tissue treated by Fr-E5 was found to be 30.9 ± 0.72μg/mg. Acetic acid induced increase in capillary permeability test results revealed that Fr-E5 inhibited inflammation by the value of 40.3%. Fr-E5 showed 28.1-32.2% inhibition in carrageenan-induced hind paw edema test while did not possess activity on TPA-induced ear edema and FCA-induced arthritis models. Trifolirhizin, ononin, Medicarpin 3-O-glucoside, onogenin-7-O-glucoside and sativanone-7-O-glucoside were isolated from Fr-E5 and tested for their wound healing activities using by measuring their inhibition of hyaluronidase, collagenase and elastase enzymes. Ononin and sativanone-7-O-glucoside inhibited hyaluronidase and elastase enzymes by 31.66% and 41.75%; 45.58% and 46.88% values respectively at the dose of 100μg/mL.
CONCLUSIONS:
Among five isolated compounds, ononin and sativanone-7-O-glucoside were found to inhibit hyaluronidase and elastase enzymes. According to the results, these compounds may majorly be responsible for the wound healing activity of the extract.

Product Name	Medicarpin 3-O-glucoside
Price:
CAS No.:	52766-70-8
Catalog No.:	CFN89498
Molecular Formula:	C₂₂H₂₄O₉
Molecular Weight:	432.42 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The roots of Ononis spinosa L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phytoalexin Compound Library Anti-plant-germination and growth Compound Library Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3126 mL	11.5628 mL	23.1257 mL	46.2513 mL	57.8142 mL
5 mM	0.4625 mL	2.3126 mL	4.6251 mL	9.2503 mL	11.5628 mL
10 mM	0.2313 mL	1.1563 mL	2.3126 mL	4.6251 mL	5.7814 mL
50 mM	0.0463 mL	0.2313 mL	0.4625 mL	0.925 mL	1.1563 mL
100 mM	0.0231 mL	0.1156 mL	0.2313 mL	0.4625 mL	0.5781 mL

CFN97160	Trifolirhizin	6807-83-6	446.4	C₂₂H₂₂O₁₀
CFN96037	6alpha-Hydroxymaackiain	61218-44-8	300.3	C₁₆H₁₂O₆
CFN96000	Pisatin	20186-22-5	314.3	C₁₇H₁₄O₆
CFN96672	Sophoracarpan A	1674359-82-0	300.31	C₁₇H₁₆O₅
CFN96671	Sophoracarpan B	1674359-84-2	314.30	C₁₇H₁₄O₆
CFN95401	Meliotocarpan D	83013-81-4	316.3	C₁₇H₁₆O₆
CFN96002	1,11b-Dihydro-11b-hydroxymedicarpin	210537-04-5	288.3	C₁₆H₁₆O₅
CFN96003	1,11b-Dihydro-11b-hydroxymaackiain	210537-05-6	302.3	C₁₆H₁₄O₆
CFN89484	Pterocarpadiol D	2055882-23-8	304.29	C₁₆H₁₆O₆
CFN89483	Pterocarpadiol C	2055882-22-7	318.27	C₁₆H₁₄O₇