Science | Nature | Cell | View More
Natural Products
Medicarpin 3-O-glucoside
Medicarpin 3-O-glucoside
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Medicarpin 3-O-glucoside
Price:
CAS No.: 52766-70-8
Catalog No.: CFN89498
Molecular Formula: C22H24O9
Molecular Weight: 432.42 g/mol
Purity: >=98%
Type of Compound: Flavonoids
Physical Desc.: Powder
Source: The roots of Ononis spinosa L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
Guestbook:
Contact Us
Order & Inquiry & Tech Support

Tel: (0086)-27-84237683
Tech: service@chemfaces.com
Order: manager@chemfaces.com
Address: 176, CheCheng Eest Rd., WETDZ, Wuhan, Hubei 430056, PRC
How to Order
Orders via your E-mail:

1. Product number / Name / CAS No.
2. Delivery address
3. Ordering/billing address
4. Contact information
Order: manager@chemfaces.com
Delivery time
Delivery & Payment method

1. Usually delivery time: Next day delivery by 9:00 a.m. Order now

2. We accept: Wire transfer & Credit card & Paypal
Citing Use of our Products
* Packaging according to customer requirements(5mg, 10mg, 20mg and more). We shipped via FedEx, DHL, UPS, EMS and others courier.
According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
Other Packaging *Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap
Our products had been exported to the following research institutions and universities, And still growing.
  • Charles Sturt University (Denmark)
  • John Innes Centre (United Kingdom)
  • Chinese University of Hong Kong (China)
  • University of Dicle (Turkey)
  • Lodz University of Technology (Poland)
  • Instituto Politécnico de Bragan?a (Portugal)
  • University of Limpopo (South Africa)
  • Harvard University (USA)
  • University of Vienna (Austria)
  • Wroclaw Medical University (Poland)
  • Almansora University (Egypt)
  • More...
Package
Featured Products
3',4',5'-Trimethoxyflavone

Catalog No: CFN70439
CAS No: 67858-30-4
Price: $118/10mg
Alstonine

Catalog No: CFN97709
CAS No: 642-18-2
Price: $ /
Ferulic acid

Catalog No: CFN99158
CAS No: 1135-24-6
Price: $40/20mg
Feretoside

Catalog No: CFN98330
CAS No: 27530-67-2
Price: $268/10mg
Baicalin

Catalog No: CFN99111
CAS No: 21967-41-9
Price: $40/20mg
(-)-Pinoresinol

Catalog No: CFN92287
CAS No: 81446-29-9
Price: $268/5mg
Beta-Carotene

Catalog No: CFN98117
CAS No: 7235-40-7
Price: $40/20mg
Esculin

Catalog No: CFN99114
CAS No: 531-75-9
Price: $30/20mg
Epiberberine

Catalog No: CFN98564
CAS No: 6873-09-2
Price: $168/20mg
Inotodiol

Catalog No: CFN92367
CAS No: 35963-37-2
Price: $338/5mg
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Medicarpin-3-O-glucoside, a phytoalexin, shows inhibition against the germination of G. intraradices spores and hyphal elongation.
In vitro:
Plant Sci. 2001 Apr;160(5):925-932.
The defense response elicited by the pathogen Rhizoctonia solani is suppressed by colonization of the AM-fungus Glomus intraradices.[Pubmed: 11297789]

METHODS AND RESULTS:
Defense responses of alfalfa roots to the pathogenic fungus Rhizoctonia solani were reduced significantly in roots simultaneously infected with the vesicular arbuscular mycorrhizal (AM) fungus Glomus intraradices. R. solani induced five- to tenfold increases in the steady-state levels of chalcone isomerase and isoflavone reductase mRNAs a doubling of root peroxidase activity and a marked autofluorescence in the infected tissue. These changes were inhibited by the presence of G. intraradices. Interestingly, germination of G. intraradices spores and hyphal elongation were sensitive to low concentrations (2 µM) of Medicarpin 3-O-glucoside, an isoflavonoid phytoalexin that accumulated both in roots colonized by the pathogenic fungus as well as in AM-treated roots receiving high P, where no colonization by the beneficial fungus occurred.
CONCLUSIONS:
These data support the hypothesis that during early stages of colonization by G. intraradices, suppression of defense-related properties is associated with the successful establishment of AM symbiosis.
Medicarpin 3-O-glucoside Description
Source: The roots of Ononis spinosa L.
Solvent: DMSO, Pyridine, Methanol, Ethanol, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
ChemFaces New Products and Compounds
Bidenoside C

Catalog No: CFN95266
CAS No: 700877-55-0
Price: $318/5mg
3'-Hydroxy-5,7,4',5'-Tetramethoxyf...

Catalog No: CFN95397
CAS No: 29976-51-0
Price: $318/5mg
Bruceantinol B

Catalog No: CFN95216
CAS No: 1822332-33-1
Price: $318/5mg
Clemastanin B

Catalog No: CFN95064
CAS No: 112747-98-5
Price: $298/10mg
8-epi-Confertin

Catalog No: CFN95509
CAS No: 110115-60-1
Price: $318/5mg
Methyl ganoderate F

Catalog No: CFN95584
CAS No: 98665-08-8
Price: $368/5mg
Orthosiphol A

Catalog No: CFN95442
CAS No: 142741-25-1
Price: $318/5mg
7-(4-Hydroxyphenyl)-1-phenyl-4-hep...

Catalog No: CFN95140
CAS No: 100667-52-5
Price: $318/5mg
Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.3126 mL 11.5628 mL 23.1257 mL 46.2513 mL 57.8142 mL
5 mM 0.4625 mL 2.3126 mL 4.6251 mL 9.2503 mL 11.5628 mL
10 mM 0.2313 mL 1.1563 mL 2.3126 mL 4.6251 mL 5.7814 mL
50 mM 0.0463 mL 0.2313 mL 0.4625 mL 0.925 mL 1.1563 mL
100 mM 0.0231 mL 0.1156 mL 0.2313 mL 0.4625 mL 0.5781 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Animal Research:
J Ethnopharmacol. 2018 Jan 30;211:384-393.
Isoflavonoids as wound healing agents from Ononidis Radix.[Pubmed: 28989011 ]
Dried roots of Ononis spinosa L. are traditionally used for their diuretic, anti-inflammatory and wound healing effects. Isolation of the bioactive compounds of Ononis spinosa L. subsp. leiosperma (Boiss.) Sirj.
METHODS AND RESULTS:
Ethyl acetate extract prepared from the roots of Ononis spinosa L. subsp. leiosperma (Boiss.) Sirj. was subjected to silica gel column. The fractions were tested for their wound healing and anti-inflammatory activities. Linear incision and circular excision wound models and hydroxypyroline estimation assay were used for the wound healing activity. Carrageenan-induced hind paw edema, TPA-induced ear edema and acetic acid-induced increase in capillary permeability tests as acute inflammation; FCA-induced arthritis as chronic inflammation models were used for the assessment of anti-inflammatory activity. Antioxidant capacities of the fractions were tested using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay, 2,2-azino-bis-(3-ethylbenzthiazoline-6-sulfonic acid (ABTS) scavenging activity assay, reducing power assay and hydroxyl radical (OH-) scavenging assay. The isolation procedure was continued with the active fraction (Fr-E5). Fr-E5 exhibited remarkable wound healing activity with the 33.4% tensile strength value on the linear incision wound model and 51.4% reduction of the wound area at the day 12 on the circular excision wound model. Hydroxyproline content of the tissue treated by Fr-E5 was found to be 30.9 ± 0.72μg/mg. Acetic acid induced increase in capillary permeability test results revealed that Fr-E5 inhibited inflammation by the value of 40.3%. Fr-E5 showed 28.1-32.2% inhibition in carrageenan-induced hind paw edema test while did not possess activity on TPA-induced ear edema and FCA-induced arthritis models. Trifolirhizin, ononin, Medicarpin 3-O-glucoside, onogenin-7-O-glucoside and sativanone-7-O-glucoside were isolated from Fr-E5 and tested for their wound healing activities using by measuring their inhibition of hyaluronidase, collagenase and elastase enzymes. Ononin and sativanone-7-O-glucoside inhibited hyaluronidase and elastase enzymes by 31.66% and 41.75%; 45.58% and 46.88% values respectively at the dose of 100μg/mL.
CONCLUSIONS:
Among five isolated compounds, ononin and sativanone-7-O-glucoside were found to inhibit hyaluronidase and elastase enzymes. According to the results, these compounds may majorly be responsible for the wound healing activity of the extract.
3',4',5'-Trimethoxyflavone

Catalog No: CFN70439
CAS No: 67858-30-4
Price: $118/10mg
Alstonine

Catalog No: CFN97709
CAS No: 642-18-2
Price: $ /
Ferulic acid

Catalog No: CFN99158
CAS No: 1135-24-6
Price: $40/20mg
Feretoside

Catalog No: CFN98330
CAS No: 27530-67-2
Price: $268/10mg
Baicalin

Catalog No: CFN99111
CAS No: 21967-41-9
Price: $40/20mg
(-)-Pinoresinol

Catalog No: CFN92287
CAS No: 81446-29-9
Price: $268/5mg
Beta-Carotene

Catalog No: CFN98117
CAS No: 7235-40-7
Price: $40/20mg
Esculin

Catalog No: CFN99114
CAS No: 531-75-9
Price: $30/20mg
Epiberberine

Catalog No: CFN98564
CAS No: 6873-09-2
Price: $168/20mg
Inotodiol

Catalog No: CFN92367
CAS No: 35963-37-2
Price: $338/5mg
Tags: buy Medicarpin 3-O-glucoside | Medicarpin 3-O-glucoside supplier | purchase Medicarpin 3-O-glucoside | Medicarpin 3-O-glucoside cost | Medicarpin 3-O-glucoside manufacturer | order Medicarpin 3-O-glucoside | Medicarpin 3-O-glucoside distributor