Meliasenin B | CAS:1221262-77-6 | Manufacturer ChemFaces

Meliasenin B

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Meliasenin B may cause hepatotoxicity, it displays dose-dependent toxicity on HepG2 cells.

In vitro:

Zhongguo Zhong Yao Za Zhi. 2013 Jun;38(11):1820-2.

[Study on rapid screening and identifying hepatotoxic compounds in toosendan fructus].[Pubmed: 24010303]

METHODS AND RESULTS:
Fluorescein diacetate-labeled HepG2 cells model and flouresence automatic microscopy screening assay were used for fast screening 23 components from Toosendan Fructus, in which 5 components showed significant toxicity on HepG2 cells. The 10 compounds in the 2 components were tentatively identified with LC-MS(n), and 3 of them (Meliasenin B, trichilinin D and 1-O-tigloy-1-O-debenzoylohchinal) were prepared and identified.
CONCLUSIONS:
Further experiments showed that the 3 compounds displayed dose-dependent toxicity on HepG2 cells, suggesting that these compounds in Toosendan Fructus may cause hepatotoxicity.

Meliasenin B Description

Source:	The seeds of Melia azedarach L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Meliasenin B
Price:
CAS No.:	1221262-77-6
Catalog No.:	CFN99339
Molecular Formula:	C₃₀H₄₄O₄
Molecular Weight:	468.7 g/mol
Purity:	>=98%
Type of Compound:	Triterpenoids
Physical Desc.:	Powder
Source:	The seeds of Melia azedarach L.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Hepatotoxicity Compound Library Triterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.1336 mL	10.6678 mL	21.3356 mL	42.6712 mL	53.339 mL
5 mM	0.4267 mL	2.1336 mL	4.2671 mL	8.5342 mL	10.6678 mL
10 mM	0.2134 mL	1.0668 mL	2.1336 mL	4.2671 mL	5.3339 mL
50 mM	0.0427 mL	0.2134 mL	0.4267 mL	0.8534 mL	1.0668 mL
100 mM	0.0213 mL	0.1067 mL	0.2134 mL	0.4267 mL	0.5334 mL

CFN96722	3-Oxo-21alpha-methoxy-24,25,26,27-tetranortirucall-7-ene-23(21)-lactone	1260173-73-6	428.61	C₂₇H₄₀O₄
CFN96601	Laxiracemosin H	1241871-28-2	409.57	C₂₆H₃₅NO₃
CFN92976	Kulactone	22611-36-5	452.67	C₃₀H₄₄O₃
CFN97842	3-Epimeliasenin B	1222475-77-5	468.68	C₃₀H₄₄O₄
CFN99339	Meliasenin B	1221262-77-6	468.7	C₃₀H₄₄O₄
CFN97113	Sendanolactone	64929-59-5	466.7	C₃₀H₄₂O₄
CFN96965	Deoxyflindissone	107176-31-8	438.69	C₃₀H₄₆O₂
CFN96966	Bisabola-2,10-diene-1,9-dione	107439-25-8	234.33	C₁₅H₂₂O₂
CFN96565	Amooracetal	1351617-73-6	516.75	C₃₂H₅₂O₅
CFN97951	21,23:24,25-Diepoxy-21,23-dimethoxytirucall-7-en-3-one	1351617-74-7	514.8	C₃₂H₅₀O₅