Methyl L-pyroglutamate | CAS:4931-66-2

Methyl L-pyroglutamate

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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.

Size /Price /Stock	10 mM * 1 mL in DMSO / $7.0 / In-stock
Other Packaging	*Packaging according to customer requirements(100uL/well, 200uL/well and more), and Container use Storage Tube With Screw Cap

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Methyl L-pyroglutamate Description

Source:	The roots of Brachystemmacalycinum D.Don.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Bioorg Med Chem Lett. 2015 May 1;25(9):1965-70.

Synthesis of [(11)C]GSK1482160 as a new PET agent for targeting P2X(7) receptor.[Pubmed: 25819093 ]

METHODS AND RESULTS:
The authentic standards GSK1482160 and its isomer, as well as the radiolabeling precursors desmethyl-GSK1482160 and Boc-protected desmethyl-GSK1482160 were synthesized from L-pyroglutamic acid, Methyl L-pyroglutamate and 2-chloro-3-(trifluoromethyl)benzylamine with overall chemical yield 27-28% in 3 steps, 58% in 4 steps, 76% in 1 step and 33% in 2 steps, respectively. [(11)C]GSK1482160 was prepared from either desmethyl-GSK1482160 or Boc-protected desmethyl-GSK1482160 with [(11)C]CH3OTf through N-[(11)C]methylation and isolated by HPLC combined with SPE in 40-50% and 30-40% radiochemical yield, respectively, based on [(11)C]CO2 and decay corrected to end of bombardment (EOB).
CONCLUSIONS:
The radiochemical purity was >99%, and the specific activity at EOB was 370-1110 GBq/μmol with a total synthesis time of ～40-min from EOB.

Product Name	Methyl L-pyroglutamate
Price:	$30 / 20mg
CAS No.:	4931-66-2
Catalog No.:	CFN96755
Molecular Formula:	C₆H₉NO₃
Molecular Weight:	143.14 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Oil
Source:	The roots of Brachystemmacalycinum D.Don.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.9862 mL	34.9308 mL	69.8617 mL	139.7233 mL	174.6542 mL
5 mM	1.3972 mL	6.9862 mL	13.9723 mL	27.9447 mL	34.9308 mL
10 mM	0.6986 mL	3.4931 mL	6.9862 mL	13.9723 mL	17.4654 mL
50 mM	0.1397 mL	0.6986 mL	1.3972 mL	2.7945 mL	3.4931 mL
100 mM	0.0699 mL	0.3493 mL	0.6986 mL	1.3972 mL	1.7465 mL

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