(-)-Myrtenol | CAS:19894-97-4 | Manufacturer ChemFaces

(-)-Myrtenol

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Description:

(-)-Myrtenol has gastroprotective, and anxiolytic-like activities, which could be related to GABAA -receptor activation and antioxidant activity.

Targets:

GABAA receptor | NO | COX | SOD | GPx

In vivo:

Journal of Pharmacy & Pharmacology, 2016, 68(8):1085-1092.

Gastroprotective effect of (-)-myrtenol against ethanol-induced acute gastric lesions: possible mechanisms.[Pubmed: 27291136 ]

(-)-Myrtenol is a natural fragrance monoterpenoid structurally related to α-pinene found in diverse plant essential oils. This study was aimed to assess the anti-ulcerogenic potential of (-)-Myrtenol against ethanol-induced gastric lesions and to elucidate the underlying mechanism(s).
METHODS AND RESULTS:
Gastroprotective activity of (-)-Myrtenol was evaluated using the mouse model of ethanol-induced gastric damage. To elucidate the gastroprotective mechanism(s), the roles of GABA, prostaglandins, nitric oxide and KATP channels were assessed. Besides, the oxidative stress-related parameters and the mucus content in gastric tissues were analysed. (-)-Myrtenol at oral doses of 25, 50 and 100 mg/kg significantly decreased the severity of ethanol-induced gastric lesions affording gastroprotection that was accompanied by a decrease in the activity of myeloperoxidase and malondialdehyde, an increase in GPx, SOD, and catalase activity in gastric tissues, and with well-maintained normal levels of nitrite/nitrate, gastric mucus and NP-SHs. Pretreatment with GABA-A receptor antagonist flumazenil, the COX inhibitor indomethacin, and NO synthesis inhibitor L-NAME but not with KATP channel blocker glibenclamide significantly blocked the (-)-Myrtenol gastroprotection.
CONCLUSIONS:
These results provide first-time evidence for the gastroprotective effect of (-)-Myrtenol that could be related to GABAA -receptor activation and antioxidant activity.

(-)-Myrtenol Description

Source:	The essential oil of Myrtus communis L. (Myrtaceae)
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Neuroence Letters, 2014, 579:119-124.

Anxiolytic-like effects and mechanism of (-)-myrtenol: a monoterpene alcohol.[Pubmed: 25026073]

The essential oil of Myrtus communis L. (Myrtaceae) and its compounds have been popularly used in numerous health disorders, including insomnia and nervous conditions, but their effects on central nervous system (CNS) have not been explored yet.
METHODS AND RESULTS:
We evaluated the anxiolytic-like effects and possible action mechanism of (-)-Myrtenol (MYR), a monoterpenoid alcohol present in essential oil of M. communis L. Animal models of elevated plus maze (EPM), light-dark transition (LDT), open field and rotarod tests were used in the present study. MYR was administered in male rats. Diazepam was used as the standard drug (positive control) and flumazenil was used to elucidate the possible action mechanism. The results showed that none of the doses of MYR had effect on the resistance time in rotating bar, but caused reduction in the number of falls in rotarod tests when compared with a negative control. Similarly, MYR had no effect on the number of crossings, groomings or rearings in open field tests when compared with a negative control. However, in EPM and LDT tests, MYR significantly increased (p<0.001) the number of entries in open arms (F7,49=9.867), the time spent in open arms (F7,49=53.97) and the time spent in light compartment (F7,56=27.38), when compared with negative and positive controls, respectively. Flumazenil was able to reverse the effects of diazepam and MYR.
CONCLUSIONS:
These results suggest that MYR presents anxiolytic-like activity and that effect can be mediated by GABAergic transmission.

Product Name	(-)-Myrtenol
Price:	$30 / 20mg
CAS No.:	19894-97-4
Catalog No.:	CFN70079
Molecular Formula:	C₁₀H₁₆O
Molecular Weight:	152.2 g/mol
Purity:	>=98%
Type of Compound:	Monoterpenoids
Physical Desc.:	Oil
Source:	The essential oil of Myrtus communis L. (Myrtaceae)
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Monoterpenoids Compound Library SOD Inhibitor Library NO Inhibitor Library COX Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	6.5703 mL	32.8515 mL	65.703 mL	131.406 mL	164.2576 mL
5 mM	1.3141 mL	6.5703 mL	13.1406 mL	26.2812 mL	32.8515 mL
10 mM	0.657 mL	3.2852 mL	6.5703 mL	13.1406 mL	16.4258 mL
50 mM	0.1314 mL	0.657 mL	1.3141 mL	2.6281 mL	3.2852 mL
100 mM	0.0657 mL	0.3285 mL	0.657 mL	1.3141 mL	1.6426 mL

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