Nagilactone B | CAS:19891-51-1 | Manufacturer ChemFaces

Nagilactone B

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Description:

Nagilactone B is a liver X receptor (LXR) agonist, selective LXR activation in macrophages with nagilactone B induces ABCA1- and ABCG1-mediated cholesterol efflux while exerting minimal effects on lipogenesis and lipid accumulation in liver, resulting in regression of atherosclerosis, and therefore might be a promising strategy for therapeutics.

Targets:

Liver X receptor

In vivo:

Cardiovasc Res. 2016 Oct;112(1):502-14.

A novel small molecule liver X receptor transcriptional regulator, nagilactone B, suppresses atherosclerosis in apoE-deficient mice.[Pubmed: 27460841]

Atherosclerosis is the most common cause of cardiovascular diseases, such as myocardial infarction and stroke. We hypothesized that Nagilactone B (NLB), a small molecule extracted from the root bark of Podocarpus nagi (Podocarpaceae), suppresses atherosclerosis in an atherosclerotic mouse model.
METHODS AND RESULTS:
Male apoE-deficient mice on C57BL/6J background received NLB (10 and 30 mg/kg) for 12 weeks. Compared with the model group, NLB treatment (10 and 30 mg/kg) significantly reduced en face lesions of total aorta areas. In RAW264.7 cells, NLB significantly ameliorated cholesterol accumulation in macrophages via enhancing apolipoprotein A-I and HDL-mediated cholesterol efflux. Mechanistically, NLB induced messenger RNA and protein expression of the ATP-binding cassette transporter A1 (ABCA1) and G1 (ABCG1) in RAW264.7 and THP-1 cells. Liver X receptor (LXR) site mutations in the mouse ABCA1 promoter abrogated NLB-mediated luciferase reporter activity. LXRα and LXRβ small interfering RNA suppressed NLB-mediated induction of ABCA1 expression. Consistent with in vitro results, NLB induced ABCA1 expression and suppressed macrophage areas in the aortic sinus. Moreover, NLB treatment did not induce the protein expression of LXR in liver. Hepatic and intestinal cholesterol accumulation was significantly alleviated on NLB treatment. Besides, NLB significantly improved plasma lipid profiles in apoE-deficient mice.
CONCLUSIONS:
Selective LXR activation in macrophages with NLB induces ABCA1- and ABCG1-mediated cholesterol efflux while exerting minimal effects on lipogenesis and lipid accumulation in liver, resulting in regression of atherosclerosis, and therefore might be a promising strategy for therapeutics.

Nagilactone B Description

Source:	The herbs of Podocarpus neriifolius
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Nagilactone B
Price:
CAS No.:	19891-51-1
Catalog No.:	CFN96150
Molecular Formula:	C₁₉H₂₄O₇
Molecular Weight:	364.4 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Podocarpus neriifolius
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anti-Atherosclerotic Compound Library Diterpenoids Compound Library Liver X Receptor Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.7442 mL	13.7212 mL	27.4424 mL	54.8847 mL	68.6059 mL
5 mM	0.5488 mL	2.7442 mL	5.4885 mL	10.9769 mL	13.7212 mL
10 mM	0.2744 mL	1.3721 mL	2.7442 mL	5.4885 mL	6.8606 mL
50 mM	0.0549 mL	0.2744 mL	0.5488 mL	1.0977 mL	1.3721 mL
100 mM	0.0274 mL	0.1372 mL	0.2744 mL	0.5488 mL	0.6861 mL

CFN97733	Totarol	511-15-9	286.46	C₂₀H₃₀O
CFN98610	Totaradiol	3772-56-3	302.5	C₂₀H₃₀O₂
CFN96167	4beta-Carboxy-19-nortotarol	55102-39-1	316.4	C₂₀H₂₈O₃
CFN96140	Nagilactone C	24338-53-2	362.4	C₁₉H₂₂O₇
CFN96150	Nagilactone B	19891-51-1	364.4	C₁₉H₂₄O₇
CFN89100	Hispidanin B	1616080-84-2	656.89	C₄₂H₅₆O₆