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Nemorensine
Nemorensine
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Nemorensine
Price:
CAS No.: 50906-96-2
Catalog No.: CFN00387
Molecular Formula: C18H27NO5
Molecular Weight: 337.41 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The herbs of Senecio nemoresis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS    SDF
Similar structural: Comparison (Web)  (SDF)
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Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
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Biological Activity
Description: Reference standards.
In vitro:
Analytical Letters, 2006 , 22 (15) :3041-3055.
Indirect Determination of Pyrrolizidine Alkaloids by Flame Atomic Absorption Spectrometry[Reference: WebLink]
This paper studies the formation and extraction of ion pairs of some alkaloids derived from pyrrolizidine.
METHODS AND RESULTS:
The substances studied are Nemorensine, Platyphylline, Senecionine and Seneciphylline, and the ion pairs studied and extracted are formed with Bil4. The method consists of extracting an ion pair between the organic base and the inorganic complex, the metal is measured in the organic phase (1,2 dichloroethane) by Flame AAS. The optimal experimental conditions, pH, concentration of BiI4 , shaking time, phase ratio, number of extractions, and the range of calibration are studied for these substances. The linear range in organic phase is 0.13–1.91 mg.mL.
CONCLUSIONS:
The standard deviation of the method varies between 2.4–3.2%, depending on the substance analyzed. The interferences produced by various substances are studied.
Nemorensine Description
Source: The herbs of Senecio nemoresis
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com

After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Recently, ChemFaces products have been cited in many studies from excellent and top scientific journals

Cell. 2018 Jan 11;172(1-2):249-261.e12.
doi: 10.1016/j.cell.2017.12.019.
IF=36.216(2019)

PMID: 29328914

Cell Metab. 2020 Mar 3;31(3):534-548.e5.
doi: 10.1016/j.cmet.2020.01.002.
IF=22.415(2019)

PMID: 32004475

Mol Cell. 2017 Nov 16;68(4):673-685.e6.
doi: 10.1016/j.molcel.2017.10.022.
IF=14.548(2019)

PMID: 29149595

ACS Nano. 2018 Apr 24;12(4): 3385-3396.
doi: 10.1021/acsnano.7b08969.
IF=13.903(2019)

PMID: 29553709

Nature Plants. 2016 Dec 22;3: 16206.
doi: 10.1038/nplants.2016.205.
IF=13.297(2019)

PMID: 28005066

Sci Adv. 2018 Oct 24;4(10): eaat6994.
doi: 10.1126/sciadv.aat6994.
IF=12.804(2019)

PMID: 30417089
Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.9638 mL 14.8188 mL 29.6375 mL 59.2751 mL 74.0938 mL
5 mM 0.5928 mL 2.9638 mL 5.9275 mL 11.855 mL 14.8188 mL
10 mM 0.2964 mL 1.4819 mL 2.9638 mL 5.9275 mL 7.4094 mL
50 mM 0.0593 mL 0.2964 mL 0.5928 mL 1.1855 mL 1.4819 mL
100 mM 0.0296 mL 0.1482 mL 0.2964 mL 0.5928 mL 0.7409 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
Protocol
Structure Identification:
J Org Chem. 1999 Jul 23;64(15):5542-5546.
Enantiospecific Synthesis of (+)-Nemorensic Acid, a Necic Acid Component of the Macropyrrolizidine Alkaloid, Nemorensine.[Pubmed: 11674618]

METHODS AND RESULTS:
A concise enantiospecific synthesis of nemorensic acid 3, a necic acid component of the macropyrrolizidine alkaloid Nemorensine 2, isolated from Senecio nemorensis L., is described. Reaction of an epsilon-halo-alpha,beta-unsaturated ester (8), readily accessible from a monoterpene (-)-carvone, with samarium iodide gave a fragmentation product (9), where a carbon-carbon bond cleavage reaction occurred between the gamma and delta positions of the carbonyl group, regioselectively.
CONCLUSIONS:
Deprotection of the silyl group of 9 brought about an intramolecular cyclization to provide tetrahydrofuran derivatives (10), which, upon chemical modification of the side chain, gave nemorensic acid.
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