Oxindole | CAS:59-48-3 | Manufacturer ChemFaces

Oxindole

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Size /Price /Stock	10 mM * 1 mL in DMSO / $7.0 / In-stock
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Description:

Oxindole structure has been used in receptor tyrosine kinases (RTKs) inhibitors such as SU4984 and intedanib, the RTK family represents an important therapeutic target for anti-cancer drug development.

In vitro:

Bioorg Med Chem Lett. 2015 Aug 15;25(16):3285-9.

Synthesis of novel derivatives of oxindole, their urease inhibition and molecular docking studies.[Pubmed: 26077497]

We synthesized a series of novel 5-24 derivatives of Oxindole.
METHODS AND RESULTS:
The synthesis started from 5-chloroOxindole, which was condensed with methyl 4-carboxybezoate and result in the formation of benzolyester derivatives of Oxindole which was then treated with hydrazine hydrate. The Oxindole benzoylhydrazide was treated with aryl acetophenones and aldehydes to get target compounds 5-24. The synthesized compounds were evaluated for urease inhibition; the compound 5 (IC50 = 13.00 ± 0.35 μM) and 11 (IC50 = 19.20 ± 0.50 μM) showed potent activity as compared to the standard drug thiourea (IC50 = 21.00 ± 0.01 μM). Other compounds showed moderate to weak activity.
CONCLUSIONS:
All synthetic compounds were characterized by different spectroscopic techniques including (1)H NMR, (13)C NMR, IR and EI MS.The molecular interactions of the active compounds within the binding site of urease enzyme were studied through molecular docking simulations.

Oxindole Description

Source:	The herbs of Isatis indigotica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Bioorg Med Chem. 2014 Dec 15;22(24):6953-60.

Synthesis and biological evaluation of novel oxindole-based RTK inhibitors as anti-cancer agents.[Pubmed: 25456085]

Given that receptor tyrosine kinases (RTKs) have emerged as key regulators of all aspects of cancer development, including proliferation, invasion, angiogenesis and metastasis, the RTK family represents an important therapeutic target for anti-cancer drug development. Oxindole structure has been used in RTK inhibitors such as SU4984 and intedanib.
METHODS AND RESULTS:
In this study, two series of new heterocyclic compounds containing Oxindole scaffold have been designed and synthesized, and their inhibitory activity against the proliferation of nine cancer cell lines has been evaluated. Among them, compounds 9a and 9b displayed the strongest anti-proliferative activity with the IC50s below 10μM. Flow cytometric analysis showed that the compounds 9a and 9b dose-dependently arrested the cell cycle at G0/G1 phase. Although the leading compounds SU4984 and intedanib targets FGFR1, the kinase activity test revealed that these compounds only showed slight inhibitory activity on FGFR1 kinase.
CONCLUSIONS:
Further enzymatic test aided by molecular docking simulation in the ATP-binding site demonstrated that 9a and 9b are potent inhibitors of c-Kit kinase. These compounds are worthy of further evaluation as anticancer agents.

Product Name	Oxindole
Price:	$30 / 20mg
CAS No.:	59-48-3
Catalog No.:	CFN96151
Molecular Formula:	C₈H₇NO
Molecular Weight:	133.2 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Isatis indigotica
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Inhibitors Compound Library Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	7.5075 mL	37.5375 mL	75.0751 mL	150.1502 mL	187.6877 mL
5 mM	1.5015 mL	7.5075 mL	15.015 mL	30.03 mL	37.5375 mL
10 mM	0.7508 mL	3.7538 mL	7.5075 mL	15.015 mL	18.7688 mL
50 mM	0.1502 mL	0.7508 mL	1.5015 mL	3.003 mL	3.7538 mL
100 mM	0.0751 mL	0.3754 mL	0.7508 mL	1.5015 mL	1.8769 mL

CFN95441	Oleracein E	1021950-79-7	219.2	C₁₂H₁₃NO₃
CFN95621	1-Methyl-6,8-dimethoxyquinoline-2 1H-one	1210820-67-9	219.2	C₁₂H₁₃NO₃
CFN96376	Ravenine	20105-22-0	243.3	C₁₅H₁₇NO₂
CFN97955	4-Methoxy-1-methylquinolin-2-one	32262-18-3	189.2	C₁₁H₁₁NO₂
CFN92352	Atanine	7282-19-1	243.3	C₁₅H₁₇NO₂
CFN95772	Flindersine	523-64-8	227.3	C₁₄H₁₃NO₂
CFN92735	N-Methylflindersine	50333-13-6	241.3	C₁₅H₁₅NO₂
CFN95751	2',3'-epoxy-N-methylatanine	1384841-46-6	273.3	C₁₆H₁₉NO₃
CFN96256	Glycosolone	67879-81-6	273.3	C₁₆H₁₉NO₃
CFN95806	O-Methylglycosolone	41303-25-7	287.4	C₁₇H₂₁NO₃