Paucinervin A | CAS:1243249-16-2 | Manufacturer ChemFaces

Paucinervin A

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Description:

Paucinervin A has inhibitory effect against HeLa cell growth, with the IC50 value of 29.5 microM.

In vitro:

Bioorg Med Chem. 2010 Jul 15;18(14):4957-64.

Identification and evaluation of apoptotic compounds from Garcinia paucinervis.[Pubmed: 20594858 ]

Four new compounds, Paucinervin A, paucinervin B, paucinervin C, paucinervin D (1-4), and 15 known ones were isolated from the leaves of Garcinia paucinervis.
METHODS AND RESULTS:
The structures of the new compounds were elucidated by spectroscopic evidences. All of the 19 compounds were evaluated for their apoptosis-inducing effects using HeLa-C3 cells which have been genetically engineered to possess a fluorescent biosensor capable of detecting caspase-3 activation. Eight of them were found to activate caspase-3 in HeLa-C3 cells within 72 h at the concentration of 25 microM. Moreover, the values of IC50 were measured for all four new compounds on HeLa cells using the MTT assay. Among them, compound 2 (paucinervin B) had the lowest IC50 value of 9.5 microM, while the other three new compounds had much higher IC50 values of 29.5, 52.5, and 95.6 microM, respectively.
CONCLUSIONS:
This result shows that paucinervin B has the strongest inhibitory effect against HeLa cell growth among these four newly identified paucinervins and it may have the potential to be developed into a new anticancer candidate.

Paucinervin A Description

Source:	The leaves of Garcinia paucinervis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Paucinervin A
Price:
CAS No.:	1243249-16-2
Catalog No.:	CFN89006
Molecular Formula:	C₂₄H₂₆O₇
Molecular Weight:	426.46 g/mol
Purity:	>=98%
Type of Compound:	Xanthones
Physical Desc.:	Powder
Source:	The leaves of Garcinia paucinervis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Xanthones Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.3449 mL	11.7244 mL	23.4489 mL	46.8977 mL	58.6221 mL
5 mM	0.469 mL	2.3449 mL	4.6898 mL	9.3795 mL	11.7244 mL
10 mM	0.2345 mL	1.1724 mL	2.3449 mL	4.6898 mL	5.8622 mL
50 mM	0.0469 mL	0.2345 mL	0.469 mL	0.938 mL	1.1724 mL
100 mM	0.0234 mL	0.1172 mL	0.2345 mL	0.469 mL	0.5862 mL

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