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Periglaucine B
Periglaucine B
ChemFaces products have been cited in many studies from excellent and top scientific journals
Product Name Periglaucine B
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CAS No.: 1025023-05-5
Catalog No.: CFN96748
Molecular Formula: C20H23NO6
Molecular Weight: 373.40 g/mol
Purity: >=98%
Type of Compound: Alkaloids
Physical Desc.: Powder
Source: The aerial parts of Pericampylus glaucus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download: COA    MSDS
Similar structural: Comparison (Web)  (SDF)
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According to end customer requirements, ChemFaces provide solvent format. This solvent format of product intended use: Signaling Inhibitors, Biological activities or Pharmacological activities.
Size /Price /Stock 10 mM * 1 mL in DMSO / Inquiry
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Product Use Citation
Related Screening Libraries
Size /Price /Stock 10 mM * 100 uL in DMSO / Inquiry / In-stock
10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries
Biological Activity
Description: Periglaucine B can inhibit hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells.
Targets: HBV
In vitro:
J Nat Prod. 2008 May;71(5):760-3.
Periglaucines A-D, anti-HBV and -HIV-1 alkaloids from Pericampylus glaucus.[Pubmed: 18396905]

METHODS AND RESULTS:
Four new hasubanane-type alkaloids, periglaucine A, Periglaucine B, periglaucine C, periglaucine D (1-4), and three known alkaloids, norruffscine (5), (-)-8-oxotetrahydropalmatine (6), and (-)-8-oxocanadine (7), were isolated from the aerial parts of Pericampylus glaucus. Their structures were elucidated on the basis of extensive NMR and EIMS data, and that of periglaucine A (1) was confirmed by single-crystal X-ray diffraction.
CONCLUSIONS:
Alkaloids 1-4 inhibited hepatitis B virus (HBV) surface antigen (HBsAg) secretion in Hep G2.2.15 cells. (-)-8-Oxotetrahydropalmatine (6) possessed a high selectivity index (SI = 22.4) for HBsAg secretion of the Hep G2.2.15 cell line with an IC(50) value of 0.14 mM. Norruffscine (5) and (-)-8-oxotetrahydropalmatine (6) exhibited inhibitory activity against human immunodeficiency virus (HIV-1) with EC(50) values of 10.9 and 14.1 microM in C8166 cells (SI = 45.7 and 18.8), respectively.
Periglaucine B Description
Source: The aerial parts of Pericampylus glaucus.
Solvent: Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage: Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C).

Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving: The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.
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Cell. 2018 Jan 11;172(1-2):249-261.e12.
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Calculate Dilution Ratios(Only for Reference)
1 mg 5 mg 10 mg 20 mg 25 mg
1 mM 2.6781 mL 13.3905 mL 26.7809 mL 53.5619 mL 66.9523 mL
5 mM 0.5356 mL 2.6781 mL 5.3562 mL 10.7124 mL 13.3905 mL
10 mM 0.2678 mL 1.339 mL 2.6781 mL 5.3562 mL 6.6952 mL
50 mM 0.0536 mL 0.2678 mL 0.5356 mL 1.0712 mL 1.339 mL
100 mM 0.0268 mL 0.1339 mL 0.2678 mL 0.5356 mL 0.6695 mL
* Note: If you are in the process of experiment, it's need to make the dilution ratios of the samples. The dilution data of the sheet for your reference. Normally, it's can get a better solubility within lower of Concentrations.
CFN97858Prostephanaberrine105608-27-3343.38C19H21NO5
CFN95808Acutumine17088-50-5397.9C19H24ClNO6
CFN98640Sinoacutine4090-18-0327.4 C19H21NO4
CFN98831Dihydrooxoepistephamiersine51804-69-4405.5 C21H27NO7
CFN98965Dihydroepistephamiersine 6-acetate57361-74-7433.5 C23H31NO7
CFN98425Stephavanine33116-33-5497.5 C26H27NO9
CFN98830Oxoepistephamiersine51804-68-3403.4 C21H25NO7
CFN98856Epistephamiersine52389-15-8389.5 C21H27NO6
CFN99040Periglaucine A1025023-04-4373.4 C20H23NO6
CFN96748Periglaucine B1025023-05-5373.40C20H23NO6
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