Picrasidine S | CAS:112503-87-4 | Manufacturer ChemFaces

Picrasidine S

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Picrasidine S shows the potent cytotoxicity against human HeLa cervical, gastric MKN-28, and mouse melanoma B-16 cancer cells, it also shows the potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus aureus (MRSA) and two strains of pathogenic bacteria methicillin-sensitive Staphylococcus aureus (MSSA).

Targets:

Antifection

In vitro:

Chinese Traditional\s&\sherbal Drugs, 2015,46 (6) :803-7.

Three bis-β-carboline alkaloids from Picrasma quassioides and their bioactivities[Reference: WebLink]

To study the chemical constituents from the stems of Picrasma quassioides.
METHODS AND RESULTS:
The constituents were isolated and purified by silica gel, Sephadex LH-20, ODS column chromatographies, and preparative HPLC. Their structures were determined on the basis of their physicochemical properties and spectral data. The cytotoxic and antibacterial activities were assessed by MTT and MIC, respectively. Three β-carboline alkaloids were obtained from the 95% ethanol extract of the stems of P. quassioides and identified as picrasidine F (1), picrasidine G (2), and Picrasidine S (3). Compound 1 showed selective cytotoxicity to HeLa cell, while compounds 2 and 3 showed the potent cytotoxicity against human HeLa cervical, gastric MKN-28, and mouse melanoma B-16 cancer cells. Compounds 1-3 showed the potent antibacterial activity against two strains of pathogenic bacteria methicillin-resistant Staphylococcus aureus (MRSA) and two strains of pathogenic bacteria methicillin-sensitive Staphylococcus aureus (MSSA).
CONCLUSIONS:
The assignments of NMR data of compound 1 are reported in this paper for the first time. Compounds 1-3 show the potent cytotoxic and antibacterial activities.

Picrasidine S Description

Source:	The root barks of Picrasma quassioides
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Picrasidine S
Price:
CAS No.:	112503-87-4
Catalog No.:	CFN99223
Molecular Formula:	C₃₀H₂₉N₄O₄
Molecular Weight:	509.6 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Yellow powder
Source:	The root barks of Picrasma quassioides
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Antibacterial Compound Library Cytotoxic Compound Library Alkaloids Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	1.9623 mL	9.8116 mL	19.6232 mL	39.2465 mL	49.0581 mL
5 mM	0.3925 mL	1.9623 mL	3.9246 mL	7.8493 mL	9.8116 mL
10 mM	0.1962 mL	0.9812 mL	1.9623 mL	3.9246 mL	4.9058 mL
50 mM	0.0392 mL	0.1962 mL	0.3925 mL	0.7849 mL	0.9812 mL
100 mM	0.0196 mL	0.0981 mL	0.1962 mL	0.3925 mL	0.4906 mL

CFN97316	Picrasidine A	82652-20-8	450.5	C₂₇H₂₂N₄O₃
CFN96716	Quassidine B	1207862-37-0	452.51	C₂₇H₂₄N₄O₃
CFN99223	Picrasidine S	112503-87-4	509.6	C₃₀H₂₉N₄O₄
CFN99237	Picrasidine T	113808-03-0	481.5	C₂₈H₂₅N₄O₄