Picrasin B | CAS:26121-56-2 | Manufacturer ChemFaces

Picrasin B

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Description:

Picrasin B shows a significant clastogenic activity in cell cultures of Don lung cells of Chinese hamster.

In vitro:

J Ethnopharmacol. 2009 Oct 29;126(1):114-8.

Quassinoid constituents of Quassia amara L. leaf herbal tea. Impact on its antimalarial activity and cytotoxicity.[Pubmed: 19665539]

Our objective was to assess whether it could be contemplated to recommend Quassia amara young leaf tea for treatment against malaria, and if yes, set up a standard protocol for preparing the herbal tea.
METHODS AND RESULTS:
The leaf tea was extracted with methylene chloride and the organic extract was fractionated with HPLC. Pure compounds were characterized and their in vitro cytotoxicity and antiplasmodial activity was determined. We discovered that antimalarial Quassia amara young leaf tea contains several quassinoids: simalikalactone D (SkD, 1), Picrasin B (2), picrasin H (3), neoquassin (4), quassin (5), picrasin I (6) and picrasin J (7). These last two compounds are new. In addition, our experiments demonstrate that both biological activity and cytotoxicity of the remedy may be attributed solely to the presence of SkD.
CONCLUSIONS:
In conclusion, this preparation should not be recommended for treatment of malaria until a clinical study in humans is performed with SkD.

Picrasin B Description

Source:	The herbs of Picrasma quassioides (D. Don) Benn
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Picrasin B
Price:
CAS No.:	26121-56-2
Catalog No.:	CFN98297
Molecular Formula:	C₂₁H₂₈O₆
Molecular Weight:	376.5 g/mol
Purity:	>=98%
Type of Compound:	Diterpenoids
Physical Desc.:	Powder
Source:	The herbs of Picrasma quassioides (D. Don) Benn
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Teratogens Compound Library Diterpenoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.656 mL	13.2802 mL	26.5604 mL	53.1208 mL	66.4011 mL
5 mM	0.5312 mL	2.656 mL	5.3121 mL	10.6242 mL	13.2802 mL
10 mM	0.2656 mL	1.328 mL	2.656 mL	5.3121 mL	6.6401 mL
50 mM	0.0531 mL	0.2656 mL	0.5312 mL	1.0624 mL	1.328 mL
100 mM	0.0266 mL	0.1328 mL	0.2656 mL	0.5312 mL	0.664 mL

CFN96418	Yadanzioside M	101559-99-3	704.67	C₃₄H₄₀O₁₆
CFN97461	Picrasinol B	89498-91-9	392.5	C₂₂H₃₂O₆
CFN98297	Picrasin B	26121-56-2	376.5	C₂₁H₂₈O₆
CFN98382	Picrasin B acetate	30315-04-9	418.5	C₂₃H₃₀O₇
CFN92981	Shinjulactone L	4283-49-2	406.47	C₂₂H₃₀O₇
CFN92142	Neoquassine	76-77-7	390.5	C₂₂H₃₀O₆
CFN92143	Methylneoquassin	89498-93-1	404.5	C₂₃H₃₂O₆
CFN97246	Quassin	76-78-8	388.5	C₂₂H₂₈O₆
CFN89342	Dehydrobruceantinol	99132-99-7	604.59	C₃₀H₃₆O₁₃
CFN89343	Bruceantinoside A	79439-85-3	710.71	C₃₄H₄₆O₁₆