Picropodophyllotoxin | CAS:17434-18-3 | Manufacturer ChemFaces

Picropodophyllotoxin

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Product Name	Picropodophyllotoxin
Price:	$80 / 20mg
CAS No.:	17434-18-3
Catalog No.:	CFN90443
Molecular Formula:	C₂₂H₂₂O₈
Molecular Weight:	414.4 g/mol
Purity:	>=98%
Type of Compound:	Lignans
Physical Desc.:	Powder
Source:	The rhizomes of Dysosma versipellis (Hance.) M.Cheng
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF
Similar structural:	Comparison (Web) (SDF)
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Size /Price /Stock	10 mM * 1 mL in DMSO / $33.8 / In-stock
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Description:

Picropodophyllotoxin shows highly antifeeding and toxic activities against the 3rd-instar larve of Mythimna separate W.and the 4th-instar larvae of Pieris rapae L.and the 3rd-instar larve of Plutella xylostella L.

In vitro:

《Journal of Northwest A & F University(Natural Science Edition)》 2007-09

Study on 6 insecticidal podophyllotoxin compounds from the berries of Sabina vulgaris Ant.[Reference: WebLink]

In order to isolate other insecticidal podophyllotoxin compounds from the berries of Sabina vulgaris Ant.,six podophyllotoxin compounds were isolated by tracing with insecticidal activity.They were identified as acetyl Picropodophyllotoxin,deoxyPicropodophyllotoxin,acetyl epipodophyllotoxin,podophyllotoxin,deoxypodophyllotoxin and Picropodophyllotoxin.
METHODS AND RESULTS:
The antifeeding activities against the 3rd-instar larve of Mythimna separate W.and the toxic activities against the 4th-instar larvae of Pieris rapae L.and the 3rd-instar larve of Plutella xylostella L.were tested by leaf-disk method and leaf-dipping method,respectively.The bioassay results indicated that all these compounds showed highly antifeeding and toxic activities against the 3 tested insects.Podophyllotoxin and deoxypodophyllotoxin were the two with the highest insecticidal activities among the six,while Picropodophyllotoxin was the lowest.Besides,acetyl Picropodophyllotoxin,deoxyPicropodophyllotoxin,acetyl epipodophyllotoxin and Picropodophyllotoxin were insecticidal compounds firstly reported from S.vulgaris.

Picropodophyllotoxin Description

Source:	The rhizomes of Dysosma versipellis (Hance.) M.Cheng
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Bioprocess Biosyst Eng. 2009 Aug;32(5):663-71.

Novel biotransformation process of podophyllotoxin to produce podophyllic acid and picropodophyllotoxin by Pseudomonas aeruginosa CCTCC AB93066. Part I: process development.[Pubmed: 19115065]

A novel biotransformation process of podophyllotoxin (1) to produce Picropodophyllotoxin (2) and podophyllic acid (3) was developed in this work.
METHODS AND RESULTS:
Eight bacteria which could modify the structure of podophyllotoxin were screened out from the tested fourteen bacteria. The highest conversion of podophyllotoxin (i.e., 70.2 +/- 8.0%) was obtained when Pseudomonas aeruginosa CCTCC AB93066 was used as biocatalyst, so P. aeruginosa was selected as a typical biocatalyst in the following study. Product (2) and (3) were separated through D312 macroporous resin and sephadex LH-20 gel column chromatograph. On the basis of (1)H NMR, (13)C NMR, ESI-MS and Elemental Analysis, product (2) and (3) were identified as Picropodophyllotoxin (2) and podophyllic acid (3), respectively.
CONCLUSIONS:
This suggested the site-specific isomerization and hydrolization of podophyllotoxin occurred during its biotransformation process by P. aeruginosa. For the first time, podophyllotoxin was biotransformed into its hydrolytic derivate (i.e., podophyllic acid).

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Insecticides Compound Library Antifeedant Compound Library Lignans Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.4131 mL	12.0656 mL	24.1313 mL	48.2625 mL	60.3282 mL
5 mM	0.4826 mL	2.4131 mL	4.8263 mL	9.6525 mL	12.0656 mL
10 mM	0.2413 mL	1.2066 mL	2.4131 mL	4.8263 mL	6.0328 mL
50 mM	0.0483 mL	0.2413 mL	0.4826 mL	0.9653 mL	1.2066 mL
100 mM	0.0241 mL	0.1207 mL	0.2413 mL	0.4826 mL	0.6033 mL

CFN91909	Podophyllotoxinone	477-49-6	412.39	C₂₂H₂₀O₈
CFN90443	Picropodophyllotoxin	17434-18-3	414.4	C₂₂H₂₂O₈
CFN99168	Podophyllotoxin	518-28-5	414.41	C₂₂H₂₂O₈
CFN91618	Epipodophyllotoxin	4375-07-9	414.41	C₂₂H₂₂O₈
CFN91908	Podophyllotoxin 4-O-glucoside	16481-54-2	576.55	C₂₈H₃₂O₁₃
CFN99128	4'-Demethylepipodophyllotoxin	6559-91-7	400.38	C₂₁H₂₀O₈
CFN88020	4'-Demethyldeoxypodophyllotoxin beta-D-glucopyranoside	78178-42-4	546.5	C₂₇H₃₀O₁₂
CFN99279	Acetylepipodophyllotoxin	1180-35-4	456.5	C₂₄H₂₄O₉
CFN91537	Tetradehydropodophyllotoxin	42123-27-3	410.4	C₂₂H₁₈O₈
CFN95701	Justicidin B	17951-19-8	364.4	C₂₁H₁₆O₆