Pierreione B | CAS:1292766-21-2 | Manufacturer ChemFaces

Pierreione B

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Description:

Pierreione B is an inhibitor of mTOR signaling with strong anticancer activity. Pierreione A and Pierreione B demonstrate solid tumor selectivity with minimal cytotoxicity.

Targets:

mTOR

In vitro:

J Nat Prod. 2011 Apr 25;74(4):852-6.

Pierreiones A-D, solid tumor selective pyranoisoflavones and other cytotoxic constituents from Antheroporum pierrei.[Pubmed: 21452840 ]

METHODS AND RESULTS:
Bioassay-guided fractionation of a solid tumor selective extract of the leaves and twigs of Antheroporum pierrei acquired from the U.S. National Cancer Institute extract repository afforded four new pyranoisoflavones, pierreiones A-D (1-4), together with rotenone (5), 12a-hydroxyrotenone (6), and tephrosin (7). The structures of all new compounds were determined on the basis of their spectroscopic data, and the absolute configuration of 1 was assigned with the help of (1)H NMR analysis of its Mosher's ester derivatives.
CONCLUSIONS:
Compounds 1 and 5-7 accounted for the majority of the biological activity in terms of either cytotoxicity and/or selective toxicity to solid tumor cell lines. Pierreione A (1) and Pierreione B (2) demonstrated solid tumor selectivity with minimal cytotoxicity, while pierreione C (3) exhibited no activity.

Pierreione B Description

Source:	The leaves and twigs of Antheroporum pierrei.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Kinase Assay:

Cancer Chemother Pharmacol. 2013 Oct;72(4):799-808.

Identification of two novel inhibitors of mTOR signaling pathway based on high content screening.[Pubmed: 23934262 ]

Mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating cell growth, proliferation and survival. Dysregulation of mTOR signaling pathway is closely involved in cancer development and chemotherapy resistance. Inhibitors of mTOR signaling pathway have been demonstrated to be attractive therapeutics for cancer therapy. In the present study, we aim to discover novel mTOR signaling pathway inhibitors from a natural compound library.
METHODS AND RESULTS:
Inhibitors of mTOR signaling pathway were discovered via high content screen assay based on the subcellular localization of eukaryotic initiation factor 4E (eIF4E) in mouse embryonic fibroblast cells. Candidate compounds were further assessed in cancer cells. Phosphorylation levels of mTOR complexes downstream targets were analyzed using Western blot. Cell cytotoxicity and apoptosis were evaluated using MTS assay and flow cytometry, respectively. Two compounds, 1,4-O-diferuloylsecoisolariciresinol (IM-1) and Pierreione B (IM-2), were identified which induced significant nuclear translocation of eIF4E in a panel of cancer cells. Both of the compounds decreased the phosphorylation levels of p70 ribosomal protein S6 kinase (S6K) and eIF4E binding protein 1 (4E-BP1), resulting in cancer cell cytotoxicity and apoptosis.
CONCLUSIONS:
Via high content screen assay, two novel inhibitors of mTOR signaling, IM-1 and IM-2, were identified with strong anticancer activity. IM-1 and IM-2 could be potential candidates for anticancer therapeutics by targeting mTOR signaling pathway and as such warrants further exploration.

Product Name	Pierreione B
Price:
CAS No.:	1292766-21-2
Catalog No.:	CFN96543
Molecular Formula:	C₂₆H₂₈O₇
Molecular Weight:	452.50 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	The leaves and twigs of Antheroporum pierrei.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Anticancer Compound Library Inhibitors Compound Library Flavonoids Compound Library mTOR Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.2099 mL	11.0497 mL	22.0994 mL	44.1989 mL	55.2486 mL
5 mM	0.442 mL	2.2099 mL	4.4199 mL	8.8398 mL	11.0497 mL
10 mM	0.221 mL	1.105 mL	2.2099 mL	4.4199 mL	5.5249 mL
50 mM	0.0442 mL	0.221 mL	0.442 mL	0.884 mL	1.105 mL
100 mM	0.0221 mL	0.1105 mL	0.221 mL	0.442 mL	0.5525 mL

CFN95953	Angustone A	90686-13-8	422.5	C₂₅H₂₆O₆
CFN96505	Isoangustone A	129280-34-8	422.47	C₂₅H₂₆O₆
CFN96543	Pierreione B	1292766-21-2	452.50	C₂₆H₂₈O₇
CFN70376	3',4',7-Trihydroxyisoflavone	485-63-2	270.2	C₁₅H₁₀O₅
CFN99140	Calycosin	20575-57-9	284.26	C₁₆H₁₂O₅
CFN96186	3'-Methoxydaidzein	21913-98-4	284.3	C₁₆H₁₂O₅
CFN98737	Orobol	480-23-9	286.2	C₁₅H₁₀O₆
CFN98492	3'-O-Methylorobol	36190-95-1	300.3	C₁₆H₁₂O₆
CFN96518	7,3'-Di-O-methylorobol	104668-88-4	314.30	C₁₇H₁₄O₆
CFN90805	Pratensein	2284-31-3	300.3	C₁₆H₁₂O₆