Pilocarpine Hydrochloride | CAS:54-71-7

Pilocarpine Hydrochloride

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Description:

Pilocarpine hydrochloride appears to be effective for dry mouth associated with Sjögren's syndrome. It has acaricidal activity.

In vitro:

Rev Bras Parasitol Vet. 2016 Jun 7;25(2):248-53.

In vitro effects of Pilocarpus microphyllus extracts and pilocarpine hydrochloride on Rhipicephalus (Boophilus) microplus.[Pubmed: 27334829 ]

The aim of this study was to assess the activity of aqueous (AE) and ethanolic extracts (EE) and Pilocarpine Hydrochloride, which were extracted and isolated from Pilocarpus microphyllus (Jaborandi), respectively, on Rhipicephalus (Boophilus) microplus.
METHODS AND RESULTS:
High performance liquid chromatography (HPLC) was performed to quantify these compounds. Larval packet and adult immersion tests were conducted with different concentrations. Five AE and EE concentrations, ranging from 6.2 to 100.0 mg mL-1, and six concentrations of Pilocarpine Hydrochloride, ranging from 0.7 to 24.0 mg mL-1, were tested. The lethal concentration (LC50) of each extract for larvae and engorged females was calculated through Probit analysis. The concentration of Pilocarpine Hydrochloride obtained from the EE and the AE was 1.3 and 0.3% (m/m), respectively. Pilocarpine Hydrochloride presented the highest acaricidal activity on larvae (LC50 2.6 mg mL-1) and engorged females (LC50 11.8 mg mL-1) of R.(B.) microplus, followed by the EE which presented LC50 of 56.4 and 15.9 mg mL-1, for larvae and engorged females, respectively.
CONCLUSIONS:
Such results indicate that Pilocarpine Hydrochloride has acaricidal activity, and may be the primary compound responsible for this activity by P. microphyllus EE.

In vivo:

Journal of Japanese Society of Oral Medicine,2009,15(1):1-8.

Effect of Pilocarpine Hydrochloride Against Dry Mouth Associated with Sjogren's Syndrome.[Reference: WebLink]

METHODS AND RESULTS:
To evaluate the effect of Pilocarpine Hydrochloride for the treatment of dry mouth in patients with Sjögren's syndrome, 37 patients received 5 mg of Pilocarpine Hydrochloride three times daily, once after each meal, for 12 weeks. The increase in the saliva secretional capacity, the subjective and objective assessment of mouth dryness, and the subjective assessment of mouth dryness using a visual analogue scale;(VAS) were evaluated in this study. An improvement in all the subjects was observed beginning 4 weeks after the administration of Pilocarpine Hydrochloride. Twelve patients stopped taking pilocarpine because of adverse effects, mainly excessive sweating and nausea. However, no severe adverse effects occurred among the patients who continued treatment.
CONCLUSIONS:
Thus, Pilocarpine Hydrochloride appears to be effective for dry mouth associated with Sjögren's syndrome.

Pilocarpine Hydrochloride Description

Source:	The herbs of Pilocarpus microphyllus (Jaborandi).
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Pilocarpine Hydrochloride
Price:	$40 / 20mg
CAS No.:	54-71-7
Catalog No.:	CFN93245
Molecular Formula:	C₁₁H₁₇ClN₂O₂
Molecular Weight:	244.71 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:	The herbs of Pilocarpus microphyllus (Jaborandi).
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.0865 mL	20.4323 mL	40.8647 mL	81.7294 mL	102.1617 mL
5 mM	0.8173 mL	4.0865 mL	8.1729 mL	16.3459 mL	20.4323 mL
10 mM	0.4086 mL	2.0432 mL	4.0865 mL	8.1729 mL	10.2162 mL
50 mM	0.0817 mL	0.4086 mL	0.8173 mL	1.6346 mL	2.0432 mL
100 mM	0.0409 mL	0.2043 mL	0.4086 mL	0.8173 mL	1.0216 mL

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