Pinobanksin 5-methyl ether | CAS:119309-36-3

Pinobanksin 5-methyl ether

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Description:

Pinobanksin 5-methyl ether can induce detoxification genes.

In vitro:

Proc Natl Acad Sci U S A. 2013 May 28;110(22):8842-6.

Honey constituents up-regulate detoxification and immunity genes in the western honey bee Apis mellifera.[Pubmed: 23630255 ]

As a managed pollinator, the honey bee Apis mellifera is critical to the American agricultural enterprise. Recent colony losses have thus raised concerns; possible explanations for bee decline include nutritional deficiencies and exposures to pesticides and pathogens.
METHODS AND RESULTS:
We determined that constituents found in honey, including p-coumaric acid, pinocembrin, and Pinobanksin 5-methyl ether, specifically induce detoxification genes. These inducers are primarily found not in nectar but in pollen in the case of p-coumaric acid (a monomer of sporopollenin, the principal constituent of pollen cell walls) and propolis, a resinous material gathered and processed by bees to line wax cells. RNA-seq analysis (massively parallel RNA sequencing) revealed that p-coumaric acid specifically up-regulates all classes of detoxification genes as well as select antimicrobial peptide genes. This up-regulation has functional significance in that that adding p-coumaric acid to a diet of sucrose increases midgut metabolism of coumaphos, a widely used in-hive acaricide, by ～60%.
CONCLUSIONS:
As a major component of pollen grains, p-coumaric acid is ubiquitous in the natural diet of honey bees and may function as a nutraceutical regulating immune and detoxification processes. The widespread apicultural use of honey substitutes, including high-fructose corn syrup, may thus compromise the ability of honey bees to cope with pesticides and pathogens and contribute to colony losses.

Pinobanksin 5-methyl ether Description

Source:	From Chinese propolis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Nat Prod Commun. 2009 Jun;4(6):813-8.

Simultaneous quantification of eight major bioactive phenolic compounds in Chinese propolis by high-performance liquid chromatography.[Pubmed: 19634328]

METHODS AND RESULTS:
A simple, sensitive and specific high-performance liquid chromatography-UV (HPLC-UV) method has been developed to simultaneously quantify the eight major bioactive phenolic compounds in Chinese propolis, namely caffeic acid, isoferulic acid, 3,4-dimethoxycinnamic acid, Pinobanksin 5-methyl ether, pinocembrin, benzyl caffeate, chrysin and galangin. This HPLC assay was performed on an Agilent Zorbax Extend-C18 (250 x 4.6 mm, 5 microm) column with a gradient of methanol and 0.2% aqueous acetic acid (v/v) in 50 min, at a flow rate of 1.0 mL/min, and detected at 290 nm. All calibration curves showed good linearity (r2 > 0.999) within the test ranges. The intra- and inter-day assay precision (RSD) of eight phenolic compounds were in the range of 0.07-4.92%. The recoveries were between 98.3% and 104.8%.
CONCLUSIONS:
This assay was applied to the evaluation of nineteen samples from different origins in China. The results indicated that the developed assay could be readily utilized for the quality control of propolis.

Product Name	Pinobanksin 5-methyl ether
Price:
CAS No.:	119309-36-3
Catalog No.:	CFN89500
Molecular Formula:	C₁₆H₁₄O₅
Molecular Weight:	286.27 g/mol
Purity:	>=98%
Type of Compound:	Flavonoids
Physical Desc.:	Powder
Source:	From Chinese propolis.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Activators Compound Library Flavonoids Compound Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.4932 mL	17.466 mL	34.9321 mL	69.8641 mL	87.3301 mL
5 mM	0.6986 mL	3.4932 mL	6.9864 mL	13.9728 mL	17.466 mL
10 mM	0.3493 mL	1.7466 mL	3.4932 mL	6.9864 mL	8.733 mL
50 mM	0.0699 mL	0.3493 mL	0.6986 mL	1.3973 mL	1.7466 mL
100 mM	0.0349 mL	0.1747 mL	0.3493 mL	0.6986 mL	0.8733 mL

CFN98917	Pinobanksin	548-82-3	272.3	C₁₅H₁₂O₅
CFN98845	3-O-Acetylpinobanksin	52117-69-8	314.3	C₁₇H₁₄O₆
CFN89460	Pinobanksin 3-O-propanoate	126394-70-5	328.31	C₁₈H₁₆O₆
CFN99051	3,7-O-Diacetylpinobanksin	103553-98-6	356.3	C₁₉H₁₆O₇
CFN89500	Pinobanksin 5-methyl ether	119309-36-3	286.27	C₁₆H₁₄O₅
CFN89493	Alpinone 3-acetate	139906-49-3	328.31	C₁₈H₁₆O₆