| In vitro: |
| Phytochemistry, 2014, 103:89-98. | | Biological evaluation of secondary metabolites from the roots of Myrica adenophora.[Reference: WebLink] |
METHODS AND RESULTS:
Bioassay-guided fractionation of the roots of Myrica adenophora led to isolation of 24 known compounds and hitherto unknown compounds, including three A-type proanthocyanidins [adenodimerins A–C], two esters of sucrose [myricadenins A and B ], and the phenolic glycoside 6′-O-galloyl orbicularin. Spectroscopic analyses were used to determine their structures.
CONCLUSIONS:
Adenodimerin A, myricananin C, and myricetin showed strong 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activities, with SC50 values of 7.9, 16.3, and 15.9 μM, respectively. Adenodimerin A, myricanone, myricananin C, (−)-myricanol, myricanol 11-O-β-d-glucopyranoside, and myricetin showed stronger 2,2′-azino-bis-3-ethylbenzthiazoline-6-sulphonic acid (ABTS) radical scavenging activities than the positive control, with SC50 values of 7.5, 19.6, 12.0, 22.3, 19.6, and 15.6 μM, respectively. 5-Deoxymyricanone, Porson, 12-hydroxymyricanone (−)-myricanol, and (+)-galeon exhibited anti-tubercular activity against Mycobacterium tuberculosis H37Rv in vitro and MICs values of 25.8, 40.0, 35.8, 30.0, and 15.0 μg/mL, respectively. Myricadenin A, myricanone, myricananin C, and (−)-myricanol exhibited anti-inflammatory activities in the iNOS assay with EC50 values of 18.1, 1.00, 13.0, and 7.5 μM, respectively. |
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