Protodeltonin | CAS:94992-08-2 | Manufacturer ChemFaces

Protodeltonin

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Description:

Protodeltonin may have anti-thrombotic activity by both improving the anticoagulation activity and inhibiting platelet aggregation action. Protodeltonin can inhibit the proliferation of a panel of established human and murine cancer cell lines in vitro.

Targets:

Bcl-2/Bax | Caspase | PARP

In vitro:

Steroids. 2012 Oct;77(12):1219-27.

Cytotoxicity and apoptosis-inducing effect of steroidal saponins from Dioscorea zingiberensis Wright against cancer cells.[Pubmed: 22575181 ]

Steroidal saponins from Dioscorea zingiberensis Wright (DZW) have shown cytotoxic activity in cancer cells.
METHODS AND RESULTS:
In this study, we isolated and identified seven steroidal saponins from the rhizomes of DZW: diosgenin, trillin, diosgenin diglucoside, deltonin, zingiberensis saponin (ZS), Protodeltonin and parvifloside. Our results showed that these seven compounds inhibited the proliferation of a panel of established human and murine cancer cell lines in vitro. ZS had more cytotoxic effect than the other saponins, even close to doxorubicin on the murine colon carcinoma cell line C26. The proliferation inhibitory effect of ZS was associated with its apoptosis-inducing effect by activation of caspase-3 and caspase-9 and specific proteolytic cleavage of poly (ADP-ribose) polymerase. Exposure of C26 to ZS also resulted in Bax upregulation and Bcl-2 downregulation.
CONCLUSIONS:
In conclusion, the findings of this study demonstrated that ZS is an effective natural agent for cancer therapy, which may be mediated, in part, by induction of apoptosis, and DZW's potential as an anticancer agent is worth being further investigated.

Protodeltonin Description

Source:	The herbs of Trigonella foenum-graecum L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

Fitoterapia. 2010 Dec;81(8):1147-56.

Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H. Wright.[Pubmed: 20659537]

Steroidal saponins have long attracted scientific attention, due to their structural diversity and significant biological activities. Total steroidal saponins (TSS) extracted from the rhizomes of Dioscorea zingiberensis C.H. Wright (DZW) constitute an effective treatment for cardiovascular disease. However, the active constituents contained in DZW rhizomes and their pharmacological properties are not fully understood. The aim of this work is to determine and quantify the active constituents in DZW rhizomes using fingerprint technique, and evaluate its anti-thrombotic activity using inferior vena cava ligation thrombosis rat model and pulmonary thrombosis mice model after being gavaged with TSS for 1 or 2weeks.
METHODS AND RESULTS:
In the study, a chemical fingerprint method was firstly established and validated to quantify and standardize TSS from DZW rhizomes including parvifloside, Protodeltonin, protodioscin, protogracillin, zingiberensis saponin, deltonin, dioscin and trillin. TSS extracted from DZW rhizomes were showed to have the inhibitions on platelet aggregation (PAG) and thrombosis, and prolong activated partial thromboplastin time (APTT), thrombin time (TT), and prothrombin time (PT) in a dose-dependent manner in rats. TSS also prolonged the bleeding time and clotting time in a dose-dependent manner in mice.
CONCLUSIONS:
The results indicate that TSS could inhibit thrombosis by both improving the anticoagulation activity and inhibiting PAG action, suggesting that TSS from DZW rhizomes have the potential to reduce the risk of cardiovascular diseases by anti-thrombotic action.

Product Name	Protodeltonin
Price:
CAS No.:	94992-08-2
Catalog No.:	CFN93008
Molecular Formula:	C₅₁H₈₄O₂₃
Molecular Weight:	1065.21 g/mol
Purity:	>=98%
Type of Compound:	Steroids
Physical Desc.:	Powder
Source:	The herbs of Trigonella foenum-graecum L.
Solvent:	DMSO, Pyridine, Methanol, Ethanol, etc.
Download:	COA MSDS
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Steroids Compound Library PARP Inhibitor Library Caspase Inhibitor Library Bcl-2/Bax Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	0.9388 mL	4.6939 mL	9.3878 mL	18.7756 mL	23.4696 mL
5 mM	0.1878 mL	0.9388 mL	1.8776 mL	3.7551 mL	4.6939 mL
10 mM	0.0939 mL	0.4694 mL	0.9388 mL	1.8776 mL	2.347 mL
50 mM	0.0188 mL	0.0939 mL	0.1878 mL	0.3755 mL	0.4694 mL
100 mM	0.0094 mL	0.0469 mL	0.0939 mL	0.1878 mL	0.2347 mL

CFN90702	Parisaponin I	561007-63-4	1034.0	C₅₀H₈₂O₂₂
CFN90703	Dichotomin	53093-47-3	1195.34	C₅₇H₉₄O₂₆
CFN99532	Anemarsaponin B	139051-27-7	903.04	C₄₅H₇₄O₁₈
CFN90778	Anemarsaponin BIII	142759-74-8	903.1	C₄₅H₇₄O₁₈
CFN90779	Timorsaponin C	185432-00-2	903.1	C₄₅H₇₄O₁₈
CFN90704	Parisyunnanoside B	945865-37-2	1016.0	C₅₀H₈₀O₂₁
CFN90694	Pseudoprotodioscin	102115-79-7	1031.18	C₅₁H₈₂O₂
CFN95345	Dioscoreside C		1061.2	C₅₂H₈₄O₂₂
CFN95346	Dioscoreside E	435321-73-6	1077.2	C₅₂H₈₄O₂₃
CFN90822	Terrestrosin K	193605-07-1	1079.2	C₅₁H₈₂O₂₄