Psoracorylifol B | CAS:879290-98-9 | Manufacturer ChemFaces

Psoracorylifol B

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Description:

Psoracorylifol B has antimicrobial activity.

Targets:

Antifection

In vitro:

Tetrahedron, 2006, 62(11):2569-2575.

Psoracorylifols A–E, five novel compounds with activity against Helicobacter pylori from seeds of Psoralea corylifolia[Reference: WebLink]

METHODS AND RESULTS:
Five novel compounds, psoracorylifol A,Psoracorylifol B,psoracorylifol C, psoracorylifol D,psoracorylifol E (1–5) with important activity against Helicobacter pylori have been isolated from a well-known traditional Chinese medicine (TCM), the seeds of Psoralea corylifolia. The structures of compounds 1–5, including their absolute configurations, were established on the basis of spectral methods and biogenetic reason.
CONCLUSIONS:
The structure of 1 was confirmed by a single-crystal X-ray diffraction. Psoracorylifols D and E (4 and 5) represent an unprecedented carbon skeleton. The biogenetic origin of psoracorylifols A–E (1–5) was also postulated.

Psoracorylifol B Description

Source:	The herbs of Psoralea corylifolia Linn
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Structure Identification:

Org Lett. 2014 Jun 6;16(11):2986-9.

Scalable asymmetric total syntheses of (+)-Psoracorylifol B and (+)-ent-Psoracorylifol C.[Pubmed: 24819702 ]

METHODS AND RESULTS:
The first, asymmetric total syntheses of potent antimicrobial Psoracorylifol B (>1.3 g obtained, dr 10.5:1) with a 9.4% overall yield on a gram scale in 14 steps and ent-Psoracorylifol C with a 4.3% yield in 16 steps were achieved. The key features of our synthesis include (i) sequential, rarely explored Achmatowicz rearrangement/bicycloketalization to construct the 6,8-dioxabicyclo[3.2.1]octane core, and (ii) Cu-mediated SN2' methylation or Johnson-Claisen rearrangement to stereoselectively install the all-carbon quaternary stereocenter.
CONCLUSIONS:
This concise, highly efficient, and scalable synthetic route may provide expedited and practical access to psoracorylifols and their analogues for further biological activity evaluation.

Product Name	Psoracorylifol B
Price:
CAS No.:	879290-98-9
Catalog No.:	CFN92902
Molecular Formula:	C₁₈H₂₄O₃
Molecular Weight:	288.38 g/mol
Purity:	>=98%
Type of Compound:	Phenols
Physical Desc.:	Powder
Source:	The herbs of Psoralea corylifolia Linn
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Phenols Compound Library Antifection Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	3.4676 mL	17.3382 mL	34.6765 mL	69.3529 mL	86.6912 mL
5 mM	0.6935 mL	3.4676 mL	6.9353 mL	13.8706 mL	17.3382 mL
10 mM	0.3468 mL	1.7338 mL	3.4676 mL	6.9353 mL	8.6691 mL
50 mM	0.0694 mL	0.3468 mL	0.6935 mL	1.3871 mL	1.7338 mL
100 mM	0.0347 mL	0.1734 mL	0.3468 mL	0.6935 mL	0.8669 mL

CFN91672	Iristectorigenin A	39012-01-6	330.29	C₁₇H₁₄O₇
CFN92993	Cannabinol	521-35-7	310.43	C₂₁H₂₆O₂
CFN96647	Tasumatrol L	847835-17-0	716.73	C₃₆H₄₄O₁₅
CFN92720	Ceplignan	185244-78-4	346.3	C₁₈H₁₈O₇