Pterosin Z | CAS:34169-69-2 | Manufacturer ChemFaces

Pterosin Z

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Description:

Pterosin Z has smooth muscle relaxant activity, is approximately equipotent with that of the related fungal pterosin (EC50 of 2.9 +/- 1.6 x 10(-6) M).

Targets:

Calcium Channel

In vitro:

Planta Med. 1999 Apr;65(3):271-2.

Smooth muscle relaxant activity of pterosin Z and related compounds.[Pubmed: 10232079]

METHODS AND RESULTS:
The natural products Pterosin Z, acetylPterosin Z, originally from the fern Pteridium aquilinum, and their isopterosin analogues have been synthesized and their smooth muscle relaxation activity has been measured. All of the test compounds show activity with Pterosin Z being the most active (EC50 = 1.3 +/- 0.1 x 10(-6) M), exhibiting 100 times the activity reported for the related fern metabolites onitin (EC50 = 1 x 10(-4) M), onotisin (EC50 = 2 x 10(-3) M) and otninoside (EC50 = 7 x 10(-4) M). The smooth muscle relaxant activity of Pterosin Z is approximately equipotent with that of the related fungal pterosin (EC50 of 2.9 +/- 1.6 x 10(-6) M).
CONCLUSIONS:
These results suggest that smooth muscle relaxant activity is reduced when a phenol group is present in the pterosin nucleus and when one of the dimethyl groups is derivatized.

Pterosin Z Description

Source:	The rhizomes of Cibotium barometz (L.) J.Sm.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Product Name	Pterosin Z
Price:
CAS No.:	34169-69-2
Catalog No.:	CFN98442
Molecular Formula:	C₁₅H₂₀O₂
Molecular Weight:	232.3 g/mol
Purity:	>=98%
Type of Compound:	Sesquiterpenoids
Physical Desc.:	Powder
Source:	The rhizomes of Cibotium barometz (L.) J.Sm.
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS SDF Manual
Similar structural:	Comparison (Web) (SDF)
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Smooth muscle relaxing activity Compound Library Sesquiterpenoids Compound Library Calcium Channel Inhibitor Library

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	4.3048 mL	21.5239 mL	43.0478 mL	86.0956 mL	107.6195 mL
5 mM	0.861 mL	4.3048 mL	8.6096 mL	17.2191 mL	21.5239 mL
10 mM	0.4305 mL	2.1524 mL	4.3048 mL	8.6096 mL	10.7619 mL
50 mM	0.0861 mL	0.4305 mL	0.861 mL	1.7219 mL	2.1524 mL
100 mM	0.043 mL	0.2152 mL	0.4305 mL	0.861 mL	1.0762 mL

CFN96798	Pterosin B	34175-96-7	218.29	C₁₄H₁₈O₂
CFN96609	trans-Norpterosin C	64890-70-6	220.27	C₁₃H₁₆O₃
CFN96802	Pterosin C	35938-43-3	234.29	C₁₄H₁₈O₃
CFN80185	Pterosin G	35964-50-2	234.12	C₁₄H₁₈O₃
CFN97251	Onitin 2'-O-glucoside	76947-60-9	410.5	C₂₁H₃₀O₈
CFN98899	Onitisin	53823-03-3	264.3	C₁₅H₂₀O₄
CFN97066	Onitisin 2'-O-glucoside	62043-53-2	426.5	C₂₁H₃₀O₉
CFN98442	Pterosin Z	34169-69-2	232.3	C₁₅H₂₀O₂
CFN80051	Pterosin A	35910-16-8	248.14	C₁₅H₂₀O₃
CFN80184	Pteroside A	35910-15-7	410.19	C₂₁H₃₀O₈