Rauwolscine hydrochloride | CAS:6211-32-1

Rauwolscine hydrochloride

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Size /Price /Stock	10 mM * 1 mL in DMSO / Inquiry
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Rauwolscine hydrochloride Description

Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Storage:	Providing storage is as stated on the product vial and the vial is kept tightly sealed, the product can be stored for up to 24 months(2-8C). Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20C. Generally, these will be useable for up to two weeks. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour. Need more advice on solubility, usage and handling? Please email to: service@chemfaces.com
After receiving:	The packaging of the product may have turned upside down during transportation, resulting in the natural compounds adhering to the neck or cap of the vial. take the vial out of its packaging and gently shake to let the compounds fall to the bottom of the vial. for liquid products, centrifuge at 200-500 RPM to gather the liquid at the bottom of the vial. try to avoid loss or contamination during handling.

Animal Research:

American Journal of Physiology, 1996, 271(4 Pt 2):H1375-83.

Acute stress increases venomotor tone in conscious rats.[Reference: WebLink]

This study tested the hypothesis that acute psychological stress causes venoconstriction.
METHODS AND RESULTS:
Male Sprague-Dawley rats were instrumented with indwelling catheters in a femoral artery and vein and a balloon-tipped catheter in the right atrium. Mean arterial pressure (MAP), venous pressure, heart rate (HR), and mean circulatory filling pressure (MCFP) were monitored in conscious rats. Air-jet stress was performed before and after treatment with saline, chlorisondamine, phentolamine, or prazosin. Air-jet stress caused MAP, HR, and MCFP to increase by 10 +/- 1 mmHg, 31 +/- 4 beats/min, and 0.95 +/- 0.09 mmHg, respectively. Treatment with either chlorisondamine or phentolamine was equally effective in abolishing the stress-induced increases in MAP, HR, and MCFP. Prazosin treatment abolished the pressor response to air-jet stress but did not significantly affect the HR and MCFP responses. In contrast, pretreatment with the alpha 2-receptor antagonist Rauwolscine hydrochloride abolished both the MAP and MCFP responses to air-jet stress but did not affect the HR response.
CONCLUSIONS:
These findings indicate that venoconstriction is an important component of the cardiovascular response to acute psychological stress. Stress-induced venoconstriction appears to be mediated primarily via the alpha 2-receptor subtype.

Product Name	Rauwolscine hydrochloride
Price:
CAS No.:	6211-32-1
Catalog No.:	CFN70484
Molecular Formula:	C₂₁H₂₇ClN₂O₃
Molecular Weight:	390.9 g/mol
Purity:	>=98%
Type of Compound:	Alkaloids
Physical Desc.:	Powder
Source:
Solvent:	Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
Download:	COA MSDS
Similar structural:	Comparison
Guestbook:

Size /Price /Stock	10 mM * 100 uL in DMSO / Inquiry / In-stock 10 mM * 1 mL in DMSO / Inquiry / In-stock
Related Libraries	Alkaloids Compound Library

Description:	Rauwolscine hydrochloride is an alpha 2-receptor antagonist.
Targets:	alpha 2-receptor

	1 mg	5 mg	10 mg	20 mg	25 mg
1 mM	2.5582 mL	12.791 mL	25.582 mL	51.164 mL	63.955 mL
5 mM	0.5116 mL	2.5582 mL	5.1164 mL	10.2328 mL	12.791 mL
10 mM	0.2558 mL	1.2791 mL	2.5582 mL	5.1164 mL	6.3955 mL
50 mM	0.0512 mL	0.2558 mL	0.5116 mL	1.0233 mL	1.2791 mL
100 mM	0.0256 mL	0.1279 mL	0.2558 mL	0.5116 mL	0.6395 mL

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CFN94800	Oleic acid	112-80-1	282.5	C₁₈H₃₄O₂
CFN97487	21-Deoxyneridienone B	924910-83-8	328.5	C₂₁H₂₈O₃
CFN91817	N-Methylcolchicine	7336-40-5	413.5	C₂₃H₂₇NO₆